Matches in SemOpenAlex for { <https://semopenalex.org/work/W2087495866> ?p ?o ?g. }
- W2087495866 endingPage "815" @default.
- W2087495866 startingPage "798" @default.
- W2087495866 abstract "Innate immunity to microorganisms in mammals has gained a substantial interest during the last decade. The discovery of the Toll-like receptor (TLR) family has allowed the identification of a class of membrane-spanning receptors dedicated to microbial sensing. TLRs transduce downstream signaling via their intracellular Toll–interleukin-1 receptor (TIR) domain. More recently, the role of intracellular microbial sensors has been uncovered. These molecules include the Nod-like receptors Nod1, Nod2, Ipaf and Nalps, together with the helicase domain-containing antiviral proteins RIG-I and Mda-5. The intracellular microbial sensors lack the TIR domain, but instead transduce downstream signals via two domains also implicated in homophilic protein–protein interactions, the caspase activation and recruitment domain (CARD) and PYRIN domains. In light with these recent findings, we propose that TIR, CARD and PYRIN domains represent the three arms of innate immune detection of microorganisms in mammals." @default.
- W2087495866 created "2016-06-24" @default.
- W2087495866 creator A5057038887 @default.
- W2087495866 creator A5065161854 @default.
- W2087495866 creator A5070424975 @default.
- W2087495866 date "2006-03-10" @default.
- W2087495866 modified "2023-10-14" @default.
- W2087495866 title "TIR, CARD and PYRIN: three domains for an antimicrobial triad" @default.
- W2087495866 cites W1483162601 @default.
- W2087495866 cites W1519633296 @default.
- W2087495866 cites W1524848610 @default.
- W2087495866 cites W1529674879 @default.
- W2087495866 cites W1542410645 @default.
- W2087495866 cites W1569685664 @default.
- W2087495866 cites W1594212912 @default.
- W2087495866 cites W1642457845 @default.
- W2087495866 cites W1964232474 @default.
- W2087495866 cites W1969072247 @default.
- W2087495866 cites W1969603232 @default.
- W2087495866 cites W1970100427 @default.
- W2087495866 cites W1972745528 @default.
- W2087495866 cites W1973394808 @default.
- W2087495866 cites W1973472843 @default.
- W2087495866 cites W1974623065 @default.
- W2087495866 cites W1974895889 @default.
- W2087495866 cites W1975032025 @default.
- W2087495866 cites W1976704840 @default.
- W2087495866 cites W1980168760 @default.
- W2087495866 cites W1980273234 @default.
- W2087495866 cites W1981837371 @default.
- W2087495866 cites W1986178107 @default.
- W2087495866 cites W1988192415 @default.
- W2087495866 cites W1988977784 @default.
- W2087495866 cites W1991025828 @default.
- W2087495866 cites W1994391392 @default.
- W2087495866 cites W1995321760 @default.
- W2087495866 cites W1996120614 @default.
- W2087495866 cites W1998805856 @default.
- W2087495866 cites W2001921163 @default.
- W2087495866 cites W2003634035 @default.
- W2087495866 cites W2003784229 @default.
- W2087495866 cites W2004684128 @default.
- W2087495866 cites W2005148035 @default.
- W2087495866 cites W2007508109 @default.
- W2087495866 cites W2008045357 @default.
- W2087495866 cites W2008390343 @default.
- W2087495866 cites W2009800174 @default.
- W2087495866 cites W2010453472 @default.
- W2087495866 cites W2012744652 @default.
- W2087495866 cites W2014679946 @default.
- W2087495866 cites W2015803808 @default.
- W2087495866 cites W2016292931 @default.
- W2087495866 cites W2018542503 @default.
- W2087495866 cites W2018828712 @default.
- W2087495866 cites W2020908160 @default.
- W2087495866 cites W2022057836 @default.
- W2087495866 cites W2025980739 @default.
- W2087495866 cites W2038486513 @default.
- W2087495866 cites W2040024879 @default.
- W2087495866 cites W2040230044 @default.
- W2087495866 cites W2040706148 @default.
- W2087495866 cites W2040853949 @default.
- W2087495866 cites W2041170922 @default.
- W2087495866 cites W2043667001 @default.
- W2087495866 cites W2045256187 @default.
- W2087495866 cites W2045743590 @default.
- W2087495866 cites W2048000602 @default.
- W2087495866 cites W2049115723 @default.
- W2087495866 cites W2050948458 @default.
- W2087495866 cites W2051804005 @default.
- W2087495866 cites W2052106057 @default.
- W2087495866 cites W2052521175 @default.
- W2087495866 cites W2056428779 @default.
- W2087495866 cites W2056502408 @default.
- W2087495866 cites W2058852263 @default.
- W2087495866 cites W2061626698 @default.
- W2087495866 cites W2073731887 @default.
- W2087495866 cites W2075145828 @default.
- W2087495866 cites W2075583035 @default.
- W2087495866 cites W2075948284 @default.
- W2087495866 cites W2079183583 @default.
- W2087495866 cites W2079357488 @default.
- W2087495866 cites W2079778407 @default.
- W2087495866 cites W2090859543 @default.
- W2087495866 cites W2091028482 @default.
- W2087495866 cites W2093579074 @default.
- W2087495866 cites W2096671043 @default.
- W2087495866 cites W2098676417 @default.
- W2087495866 cites W2100665873 @default.
- W2087495866 cites W2101525702 @default.
- W2087495866 cites W2104160845 @default.
- W2087495866 cites W2104472257 @default.
- W2087495866 cites W2107513655 @default.
- W2087495866 cites W2107674270 @default.
- W2087495866 cites W2108661081 @default.
- W2087495866 cites W2109381735 @default.
- W2087495866 cites W2110372095 @default.
- W2087495866 cites W2110590976 @default.