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- W2087496716 abstract "Several heparin preparations have been assayed using the Denson and Bonnar anti-Xa assay. The heat defibrination step involved in this assay has been shown to introduce discrepancies into the results, due mainly to co-precipitation of the heparin with fibrinogen. The amount of heparin lost is dependant on the molecular weight. The anti-Xa activity of ex vivo samples from subjects given heparin was much more resistant to loss during defibrination than in vitro samples, resulting in artificially high potency estimates. A modified assay has been proposed, omitting the defibrination step. The results provide further evidence that the anti-Xa activity observed after subcutaneous injection of heparin differs from that measured when the drug is added to plasma in vitro." @default.
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- W2087496716 date "1981-11-01" @default.
- W2087496716 modified "2023-10-15" @default.
- W2087496716 title "In vitro and in vivo studies of the anti-Xa activity of heparin" @default.
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- W2087496716 doi "https://doi.org/10.1016/0049-3848(81)90005-0" @default.
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