Matches in SemOpenAlex for { <https://semopenalex.org/work/W2087510980> ?p ?o ?g. }
- W2087510980 endingPage "1316" @default.
- W2087510980 startingPage "1308" @default.
- W2087510980 abstract "Abstract CD1d-restricted T cells have been implicated in the pathogenesis of several chronic inflammatory states. However, the nature of the specific ligands recognized by these cells in vivo in patients with inflammatory or malignant diseases remains unknown. We took a biochemical approach to directly isolate and characterize the nature of CD1d-binding ligands from the plasma of myeloma patients. Characterization of these ligands revealed several lysophosphatidylcholine (LPC) species. Human LPC-CD1d dimer binding cells are T-cell receptorαβ+ T cells but predominantly Vα24−Vβ11−. Cytokine secretion by LPC-specific T cells is skewed toward IL-13 secretion, and the frequencies of these cells are increased in myeloma patients relative to healthy donors. These data identify a distinct population of human CD1d-restricted T cells specific for inflammation-associated lysolipids and suggest a novel mechanism for inflammation mediated immune regulation in human cancer." @default.
- W2087510980 created "2016-06-24" @default.
- W2087510980 creator A5004466299 @default.
- W2087510980 creator A5011373942 @default.
- W2087510980 creator A5014513613 @default.
- W2087510980 creator A5019063407 @default.
- W2087510980 creator A5028046297 @default.
- W2087510980 creator A5042901726 @default.
- W2087510980 creator A5058375680 @default.
- W2087510980 creator A5068372296 @default.
- W2087510980 creator A5075752370 @default.
- W2087510980 creator A5088696429 @default.
- W2087510980 date "2008-08-15" @default.
- W2087510980 modified "2023-09-27" @default.
- W2087510980 title "Inflammation-associated lysophospholipids as ligands for CD1d-restricted T cells in human cancer" @default.
- W2087510980 cites W1492484297 @default.
- W2087510980 cites W1538172952 @default.
- W2087510980 cites W1551389252 @default.
- W2087510980 cites W1554022361 @default.
- W2087510980 cites W1570517267 @default.
- W2087510980 cites W1595766784 @default.
- W2087510980 cites W1603659997 @default.
- W2087510980 cites W1965718145 @default.
- W2087510980 cites W1971459623 @default.
- W2087510980 cites W1976710853 @default.
- W2087510980 cites W1984655283 @default.
- W2087510980 cites W1991628696 @default.
- W2087510980 cites W1992203600 @default.
- W2087510980 cites W2008798354 @default.
- W2087510980 cites W2015290904 @default.
- W2087510980 cites W2024192918 @default.
- W2087510980 cites W2028710288 @default.
- W2087510980 cites W2041844065 @default.
- W2087510980 cites W2046549183 @default.
- W2087510980 cites W2049869153 @default.
- W2087510980 cites W2052397619 @default.
- W2087510980 cites W2053088462 @default.
- W2087510980 cites W2063026834 @default.
- W2087510980 cites W2067754261 @default.
- W2087510980 cites W2074619822 @default.
- W2087510980 cites W2077417036 @default.
- W2087510980 cites W2083652774 @default.
- W2087510980 cites W2100495456 @default.
- W2087510980 cites W2118330057 @default.
- W2087510980 cites W2119555210 @default.
- W2087510980 cites W2124145182 @default.
- W2087510980 cites W2135505001 @default.
- W2087510980 cites W2135587767 @default.
- W2087510980 cites W2154645461 @default.
- W2087510980 cites W2161246044 @default.
- W2087510980 cites W2165107917 @default.
- W2087510980 cites W2168460037 @default.
- W2087510980 cites W2168938667 @default.
- W2087510980 cites W2170266529 @default.
- W2087510980 cites W2300552860 @default.
- W2087510980 cites W2951052348 @default.
- W2087510980 cites W4254839291 @default.
- W2087510980 doi "https://doi.org/10.1182/blood-2008-04-149831" @default.
- W2087510980 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2515141" @default.
- W2087510980 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18535199" @default.
- W2087510980 hasPublicationYear "2008" @default.
- W2087510980 type Work @default.
- W2087510980 sameAs 2087510980 @default.
- W2087510980 citedByCount "131" @default.
- W2087510980 countsByYear W20875109802012 @default.
- W2087510980 countsByYear W20875109802013 @default.
- W2087510980 countsByYear W20875109802014 @default.
- W2087510980 countsByYear W20875109802015 @default.
- W2087510980 countsByYear W20875109802016 @default.
- W2087510980 countsByYear W20875109802017 @default.
- W2087510980 countsByYear W20875109802018 @default.
- W2087510980 countsByYear W20875109802019 @default.
- W2087510980 countsByYear W20875109802020 @default.
- W2087510980 countsByYear W20875109802021 @default.
- W2087510980 countsByYear W20875109802022 @default.
- W2087510980 countsByYear W20875109802023 @default.
- W2087510980 crossrefType "journal-article" @default.
- W2087510980 hasAuthorship W2087510980A5004466299 @default.
- W2087510980 hasAuthorship W2087510980A5011373942 @default.
- W2087510980 hasAuthorship W2087510980A5014513613 @default.
- W2087510980 hasAuthorship W2087510980A5019063407 @default.
- W2087510980 hasAuthorship W2087510980A5028046297 @default.
- W2087510980 hasAuthorship W2087510980A5042901726 @default.
- W2087510980 hasAuthorship W2087510980A5058375680 @default.
- W2087510980 hasAuthorship W2087510980A5068372296 @default.
- W2087510980 hasAuthorship W2087510980A5075752370 @default.
- W2087510980 hasAuthorship W2087510980A5088696429 @default.
- W2087510980 hasBestOaLocation W20875109801 @default.
- W2087510980 hasConcept C203014093 @default.
- W2087510980 hasConcept C2776914184 @default.
- W2087510980 hasConcept C2908647359 @default.
- W2087510980 hasConcept C49039625 @default.
- W2087510980 hasConcept C502942594 @default.
- W2087510980 hasConcept C55493867 @default.
- W2087510980 hasConcept C71924100 @default.
- W2087510980 hasConcept C86803240 @default.
- W2087510980 hasConcept C8891405 @default.
- W2087510980 hasConcept C95444343 @default.