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• W2087514104 abstract "Testosterone (T) regulates expression of protein-encoding genes directly through androgen receptor (AR) targeting androgen response element (ARE) in gene promoters or indirectly through non-genotropic mechanisms, but only limited information is available about T effects on expression of gene-regulatory non-coding miRNAs. Here, we investigate the effect of T on miRNA expression profiles in the female mouse liver using miRXplore microarrays and quantitative RT-PCR. T treatment for 3 weeks induced upregulation of the 6 miRNAs miR-22, miR-690, miR-122, let-7A, miR-30D and let-7D, reaching maximal expression at different time-points during T treatment. This upregulation was transient, i.e. it disappeared after T withdrawal for 12 weeks, and it was rather robust since it was not essentially affected by blood-stage infections with Plasmodium chabaudi malaria. In silico analysis revealed an ARE in the miR-122 promoter, while the other 5 miRNAs did not contain any ARE in their 2000 bp promoters. The T-induced upregulation of the 6 miRNAs coincided with a downregulation of some of their target protein-encoding genes, the majority of which did incidentally not contain any ARE in their promoters. T treatment did not affect expression of AR and estrogen receptor β (ERβ), but significantly downregulated the miR-22 target genes ERα and aromatase. This downregulation is presumably not caused by T after its aromatase-mediated conversion to E2 through ER, but rather by the T-induced upregulation of miR-22. Collectively, our data suggest that T can regulate expression of distinct miRNAs in vivo by both genotropic and non-genotropic mechanisms." @default.
• W2087514104 created "2016-06-24" @default.
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• W2087514104 creator A5072937215 @default.
• W2087514104 creator A5085321316 @default.
• W2087514104 date "2010-12-01" @default.
• W2087514104 modified "2023-10-04" @default.
• W2087514104 title "Testosterone-induced upregulation of miRNAs in the female mouse liver" @default.
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• W2087514104 doi "https://doi.org/10.1016/j.steroids.2010.06.010" @default.
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