FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2087514248> ?p ?o ?g. }

• W2087514248 endingPage "940" @default.
• W2087514248 startingPage "934" @default.
• W2087514248 abstract "Se ha indicado que la utilización de dosis altas de estatinas podría reducir la aparición de nuevos eventos cardiovasculares en comparación con las dosis convencionales. Nuestro objetivo fue estudiar el efecto del incremento de la dosis de atorvastatina (80 mg/día) en diferentes marcadores del sistema inflamatorio (proteína C reactiva [PCR]), hemostático (fragmento F 1+2 de la protrombina [F1+2]) y fibrinolítico (activador tisular del plasminógeno antigénico [t-PA] y su inhibidor [PAI-1]). Se estudió a 27 pacientes con cardiopatía isquémica de alto riesgo que presentaban cifras lipídicas superiores a las recomendadas a pesar del tratamiento con 40 mg/día de atorvastatina. Se compararon con 21 sujetos normocolesterolémicos sin enfermedad arteriosclerótica conocida. Se revaluó a 24 pacientes a los 3 meses del incremento de la dosis. Los pacientes presentaron cifras elevadas de PCR, F1+2, t-PA, y PAI-1 en comparación con el grupo control (en todos, las variables tuvieron un valor de p < 0,05). Tras incrementar la dosis de atorvastatina se observó una reducción de las cifras de PCR, F1+2 y PAI-1 (p < 0,05). Se observó una correlación positiva entre los porcentajes de reducción de colesterol y del F1+2 (r = 0,46; p = 0,023), sin que se hallara otra correlación significativa entre los demás parámetros. Al incrementar las dosis de atorvastatina a 80 mg/día se consigue una reducción de los estados inflamatorios, trombógenicos e hipofibrinolíticos en un grupo de pacientes con cardiopatía isquémica de alto riesgo y cifras elevadas de lípidos a pesar del tratamiento con dosis de 40 mg/día de atorvastatina. It has been suggested that high doses of statins can be more effective in reducing the incidence of new cardiovascular events than conventional doses. The present study analyzed the effect of increasing the atorvastatin dose to 80 mg/day on indices of inflammation (C-reactive protein or CRP), thrombogenesis (prothrombin fragment [F1+2]) and fibrinolysis (tissue- type plasminogen activator antigen, t-PA, and its inhibitor PAI-1) in high-risk patients with ischemic heart disease. We studied 27 patients with high-risk coronary heart disease who had lipid levels above those recommended despite treatment with atorvastatin at 40 mg/day. At baseline, patients were compared with 21 normocholesterolemic subjects without arteriosclerotic disease. Twenty-four patients were reevaluated 3 months after the atorvastatin dose was increased to 80 mg/day. The CRP, F1+2, t-PA and PAI-1 levels were significantly higher in patients than control subjects (all P<.05). After the atorvastatin dose was increased, significant reductions in CRP, F1+2, and PAI-1 levels were observed (P<.05). There was a significant positive correlation between the reduction in cholesterol level and that in F1+2 (r =0.43; P=.023). No other significant correlations were found. In a group of patient with high-risk heart disease and elevated lipid levels, increasing the atorvastatin dose led to significant improvements in inflammatory, thrombogenic, and hypofibrinolytic states." @default.
• W2087514248 created "2016-06-24" @default.
• W2087514248 creator A5005452555 @default.
• W2087514248 creator A5007245327 @default.
• W2087514248 creator A5011981189 @default.
• W2087514248 creator A5034796460 @default.
• W2087514248 creator A5052463405 @default.
• W2087514248 creator A5077885652 @default.
• W2087514248 creator A5078030000 @default.
• W2087514248 creator A5089912760 @default.
• W2087514248 date "2005-08-01" @default.
• W2087514248 modified "2023-10-02" @default.
• W2087514248 title "Efecto de dosis máximas de atorvastatina en la inflamación, la trombogénesis y la función fibrinolítica en pacientes con cardiopatía isquémica de alto riesgo" @default.
• W2087514248 cites W1560941842 @default.
• W2087514248 cites W1651383390 @default.
• W2087514248 cites W1963646420 @default.
• W2087514248 cites W1966000886 @default.
• W2087514248 cites W1972462776 @default.
• W2087514248 cites W1986055387 @default.
• W2087514248 cites W2026172290 @default.
• W2087514248 cites W2034770905 @default.
• W2087514248 cites W2051419940 @default.
• W2087514248 cites W2058610049 @default.
• W2087514248 cites W2070396041 @default.
• W2087514248 cites W2073629985 @default.
• W2087514248 cites W2073749453 @default.
• W2087514248 cites W2086081611 @default.
• W2087514248 cites W2098946775 @default.
• W2087514248 cites W2102899779 @default.
• W2087514248 cites W2106343349 @default.
• W2087514248 cites W2109629533 @default.
• W2087514248 cites W2118154631 @default.
• W2087514248 cites W2118667643 @default.
• W2087514248 cites W2118867086 @default.
• W2087514248 cites W2124551895 @default.
• W2087514248 cites W2128722360 @default.
• W2087514248 cites W2129750583 @default.
• W2087514248 cites W2155598961 @default.
• W2087514248 cites W2159449551 @default.
• W2087514248 cites W2159633079 @default.
• W2087514248 cites W2160152341 @default.
• W2087514248 cites W2166910397 @default.
• W2087514248 cites W2316243284 @default.
• W2087514248 cites W2322095705 @default.
• W2087514248 cites W2324841714 @default.
• W2087514248 cites W4210953454 @default.
• W2087514248 cites W4231034719 @default.
• W2087514248 cites W4238251256 @default.
• W2087514248 cites W4239800189 @default.
• W2087514248 cites W4243299554 @default.
• W2087514248 cites W4244345895 @default.
• W2087514248 cites W424467158 @default.
• W2087514248 cites W4248918123 @default.
• W2087514248 cites W4251378284 @default.
• W2087514248 doi "https://doi.org/10.1157/13078130" @default.
• W2087514248 hasPublicationYear "2005" @default.
• W2087514248 type Work @default.
• W2087514248 sameAs 2087514248 @default.
• W2087514248 citedByCount "6" @default.
• W2087514248 countsByYear W20875142482013 @default.
• W2087514248 countsByYear W20875142482020 @default.
• W2087514248 crossrefType "journal-article" @default.
• W2087514248 hasAuthorship W2087514248A5005452555 @default.
• W2087514248 hasAuthorship W2087514248A5007245327 @default.
• W2087514248 hasAuthorship W2087514248A5011981189 @default.
• W2087514248 hasAuthorship W2087514248A5034796460 @default.
• W2087514248 hasAuthorship W2087514248A5052463405 @default.
• W2087514248 hasAuthorship W2087514248A5077885652 @default.
• W2087514248 hasAuthorship W2087514248A5078030000 @default.
• W2087514248 hasAuthorship W2087514248A5089912760 @default.
• W2087514248 hasConcept C138885662 @default.
• W2087514248 hasConcept C15708023 @default.
• W2087514248 hasConcept C29456083 @default.
• W2087514248 hasConcept C71924100 @default.
• W2087514248 hasConceptScore W2087514248C138885662 @default.
• W2087514248 hasConceptScore W2087514248C15708023 @default.
• W2087514248 hasConceptScore W2087514248C29456083 @default.
• W2087514248 hasConceptScore W2087514248C71924100 @default.
• W2087514248 hasIssue "8" @default.
• W2087514248 hasLocation W20875142481 @default.
• W2087514248 hasOpenAccess W2087514248 @default.
• W2087514248 hasPrimaryLocation W20875142481 @default.
• W2087514248 hasRelatedWork W1506200166 @default.
• W2087514248 hasRelatedWork W1995515455 @default.
• W2087514248 hasRelatedWork W2048182022 @default.
• W2087514248 hasRelatedWork W2080531066 @default.
• W2087514248 hasRelatedWork W2604872355 @default.
• W2087514248 hasRelatedWork W2748952813 @default.
• W2087514248 hasRelatedWork W2899084033 @default.
• W2087514248 hasRelatedWork W3031052312 @default.
• W2087514248 hasRelatedWork W3032375762 @default.
• W2087514248 hasRelatedWork W3108674512 @default.
• W2087514248 hasVolume "58" @default.
• W2087514248 isParatext "false" @default.
• W2087514248 isRetracted "false" @default.
• W2087514248 magId "2087514248" @default.
• W2087514248 workType "article" @default.