FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2087514588> ?p ?o ?g. }

• W2087514588 endingPage "1007" @default.
• W2087514588 startingPage "999" @default.
• W2087514588 abstract "The time course of the formation of synaptic long-term depression was analysed in neurons of Helix pomatia. Polysynaptic excitatory postsynaptic potentials were evoked in identified neurons by stimulation of the right pallial nerve. First, synaptic depression was observed during four consecutive series of excitatory postsynaptic potentials spaced by either 2, 10 or 60 min in the presence and absence of compounds inhibiting protein synthesis. Inhibition of RNA translation (but not of transcription) reduced the increasing depression of series spaced by 10 and 60 min but not by 2 min. This demonstration of translation-dependent depression present only 10 min after a previous excitatory postsynaptic potential series was analysed further by observations of the time course of excitatory postsynaptic potential recovery from short-term depression in experiments with intact versus inhibited protein synthesis. When synthesis was inhibited, recovery occurred along a double-exponential trajectory. However, when synthesis was intact, the exponential recovery was interrupted discontinuously 6-10 min after a series of excitatory postsynaptic potentials by the onset of a spontaneous and increasing depression lasting for at least 12 h. Puromycin, anisomycin and actinomycin D were used as inhibitors not affecting the short-term properties of excitatory postsynaptic potentials. Experiments with camptothecin, on the other hand, revealed that this inhibitor enhanced excitatory postsynaptic potential amplitudes and reduced their short-term depression. It is concluded that long-term depression, depending upon de novo protein synthesis, was initiated only 10 min after a series of excitatory postsynaptic potentials. Evidence was obtained indicating that this early initiated protein synthesis circumvented the transcription processes within the cell nuclei." @default.
• W2087514588 created "2016-06-24" @default.
• W2087514588 creator A5047552773 @default.
• W2087514588 creator A5061176156 @default.
• W2087514588 date "1996-08-01" @default.
• W2087514588 modified "2023-10-18" @default.
• W2087514588 title "Role of protein synthesis in the transition from synaptic short-term to long-term depression in neurons of Helix pomatia" @default.
• W2087514588 cites W1970409943 @default.
• W2087514588 cites W1986736108 @default.
• W2087514588 cites W1992165954 @default.
• W2087514588 cites W2007973090 @default.
• W2087514588 cites W2029692753 @default.
• W2087514588 cites W2036214307 @default.
• W2087514588 cites W2066081686 @default.
• W2087514588 cites W2080480553 @default.
• W2087514588 cites W2081700464 @default.
• W2087514588 cites W2086238626 @default.
• W2087514588 cites W2088353851 @default.
• W2087514588 cites W2094043543 @default.
• W2087514588 cites W2133752568 @default.
• W2087514588 cites W2157713791 @default.
• W2087514588 cites W2184636312 @default.
• W2087514588 cites W2184744982 @default.
• W2087514588 cites W2333192876 @default.
• W2087514588 cites W614894750 @default.
• W2087514588 cites W995193556 @default.
• W2087514588 doi "https://doi.org/10.1016/0306-4522(96)00068-1" @default.
• W2087514588 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8809819" @default.
• W2087514588 hasPublicationYear "1996" @default.
• W2087514588 type Work @default.
• W2087514588 sameAs 2087514588 @default.
• W2087514588 citedByCount "7" @default.
• W2087514588 crossrefType "journal-article" @default.
• W2087514588 hasAuthorship W2087514588A5047552773 @default.
• W2087514588 hasAuthorship W2087514588A5061176156 @default.
• W2087514588 hasConcept C112592302 @default.
• W2087514588 hasConcept C118232355 @default.
• W2087514588 hasConcept C169760540 @default.
• W2087514588 hasConcept C170493617 @default.
• W2087514588 hasConcept C17077164 @default.
• W2087514588 hasConcept C185592680 @default.
• W2087514588 hasConcept C187541742 @default.
• W2087514588 hasConcept C18903297 @default.
• W2087514588 hasConcept C197341189 @default.
• W2087514588 hasConcept C2777959311 @default.
• W2087514588 hasConcept C2779965526 @default.
• W2087514588 hasConcept C2910581834 @default.
• W2087514588 hasConcept C55493867 @default.
• W2087514588 hasConcept C86803240 @default.
• W2087514588 hasConceptScore W2087514588C112592302 @default.
• W2087514588 hasConceptScore W2087514588C118232355 @default.
• W2087514588 hasConceptScore W2087514588C169760540 @default.
• W2087514588 hasConceptScore W2087514588C170493617 @default.
• W2087514588 hasConceptScore W2087514588C17077164 @default.
• W2087514588 hasConceptScore W2087514588C185592680 @default.
• W2087514588 hasConceptScore W2087514588C187541742 @default.
• W2087514588 hasConceptScore W2087514588C18903297 @default.
• W2087514588 hasConceptScore W2087514588C197341189 @default.
• W2087514588 hasConceptScore W2087514588C2777959311 @default.
• W2087514588 hasConceptScore W2087514588C2779965526 @default.
• W2087514588 hasConceptScore W2087514588C2910581834 @default.
• W2087514588 hasConceptScore W2087514588C55493867 @default.
• W2087514588 hasConceptScore W2087514588C86803240 @default.
• W2087514588 hasIssue "4" @default.
• W2087514588 hasLocation W20875145881 @default.
• W2087514588 hasLocation W20875145882 @default.
• W2087514588 hasOpenAccess W2087514588 @default.
• W2087514588 hasPrimaryLocation W20875145881 @default.
• W2087514588 hasRelatedWork W1512616480 @default.
• W2087514588 hasRelatedWork W1528719463 @default.
• W2087514588 hasRelatedWork W1995706095 @default.
• W2087514588 hasRelatedWork W2005289480 @default.
• W2087514588 hasRelatedWork W2007600010 @default.
• W2087514588 hasRelatedWork W2057776649 @default.
• W2087514588 hasRelatedWork W2625872185 @default.
• W2087514588 hasRelatedWork W40473409 @default.
• W2087514588 hasRelatedWork W4241474375 @default.
• W2087514588 hasRelatedWork W4285127779 @default.
• W2087514588 hasVolume "73" @default.
• W2087514588 isParatext "false" @default.
• W2087514588 isRetracted "false" @default.
• W2087514588 magId "2087514588" @default.
• W2087514588 workType "article" @default.