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- W2087530106 abstract "A methanol extract of the bark of Shorea roxburghii (Dipterocarpaceae) was found to inhibit plasma glucose elevation in sucrose-loaded mice. From the extract, three new 3-ethyl-4-phenyl-3,4-dihydroisocoumarins, 1′S-dihydrophayomphenol A2 (1) and phayomphenols B1 (2) and B2 (3), were isolated together with 24 known compounds including 20 stilbenoids and oligostilbenoids. The structures of 1–3 were determined on the basis of their spectroscopic properties as well as of chemical evidences. Among the isolates, (−)-hopeaphenol (6), hemsleyanol D (8), (+)-α-viniferin (15), and (−)-balanocarpol (18) showed inhibitory activity against plasma glucose elevation in sucrose-loaded rats at doses of 100–200 mg/kg, p.o. To clarify the mode of action of the antihyperglycemic property, effects of these oligostilbenoids on gastric emptying in mice, those on glucose uptake in isolated intestinal tissues as well as inhibitory activities against rat intestinal α-glucosidase and rat lens aldose reductase were examined." @default.
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- W2087530106 date "2012-01-01" @default.
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- W2087530106 title "Antidiabetogenic oligostilbenoids and 3-ethyl-4-phenyl-3,4-dihydroisocoumarins from the bark of Shorea roxburghii" @default.
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- W2087530106 doi "https://doi.org/10.1016/j.bmc.2011.11.067" @default.
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