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• W2087531572 abstract "In the present study, we investigated the implication of NF-κB in the production of pro-inflammatory cytokine IL-18 by human keratinocytes stimulated by UVB. We demonstrated that NCTC 2544 keratinocyte cell line irradiated by UVB enhanced the IL-18 mRNA and protein secretion under its bioactive form. Overexpression of IL-18 by UVB irradiation was accompanied by NF-κB transcription factor activation using specific IL-18 gene sequence corresponding to NF-κB DNA binding site. The relationship between these transcription factors and IL-18 expression was confirmed using curcumin and PDTC, two inhibitors of NF-κB. Our results show that UVB and curcumin or PDTC co-treatment led to a down-regulation of IL-18 expression associated with an inhibition of NF-κB DNA binding. Hence, our results demonstrated that this transcription factor is implicated in biologically active IL-18 production by human keratinocytes irradiated by UVB." @default.
• W2087531572 created "2016-06-24" @default.
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• W2087531572 date "2007-01-01" @default.
• W2087531572 modified "2023-09-25" @default.
• W2087531572 title "UVB-induced IL-18 production in human keratinocyte cell line NCTC 2544 through NF-κB activation" @default.
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• W2087531572 doi "https://doi.org/10.1016/j.cyto.2007.02.020" @default.
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