FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2087533476> ?p ?o ?g. }

• W2087533476 endingPage "700" @default.
• W2087533476 startingPage "689" @default.
• W2087533476 abstract "Dependence and impairment of learning and memory are two well-established features caused by abused drugs such as opioids. The hippocampus is an important region associated with both drug dependence and learning and memory. However, the molecular events in hippocampus following exposure to abused drugs such as opioids are not well understood. Here we examined the effect of chronic morphine treatment on hippocampal protein expression by proteomic analyses. We found that chronic exposure of mice to morphine for 10 days produced robust morphine withdrawal jumping and memory impairment, and also resulted in a significant downregulation of hippocampal protein levels of three metabolic enzymes, including Fe-S protein 1 of NADH dehydrogenase, dihydrolipoamide acetyltransferase or E2 component of the pyruvate dehydrogenase complex and lactate dehydrogenase 2. Further real-time quantitative PCR analyses confirmed that the levels of the corresponding mRNAs were also remarkably reduced. Consistent with these findings, lower ATP levels and an impaired ability to convert glucose into ATP were also observed in the hippocampus of chronically treated mice. Opioid antagonist naltrexone administrated concomitantly with morphine significantly suppressed morphine withdrawal jumping and reversed the downregulation of these proteins. Acute exposure to morphine also produced robust morphine withdrawal jumping and significant memory impairment, but failed to decrease the expression of these three proteins. Intrahippocampal injection of D-glucose before morphine administration significantly enhanced ATP levels and suppressed morphine withdrawal jumping and memory impairment in acute morphine-treated but not in chronic morphine-treated mice. Intraperitoneal injection of high dose of D-glucose shows a similar effect on morphine-induced withdrawal jumping as the central treatment. Taken together, our results suggest that reduced expression of the three metabolic enzymes in the hippocampus as a result of chronic morphine treatment contributes to the development of drug-induced symptoms such as morphine withdrawal jumping and memory impairment." @default.
• W2087533476 created "2016-06-24" @default.
• W2087533476 creator A5010479652 @default.
• W2087533476 creator A5019131179 @default.
• W2087533476 creator A5027256159 @default.
• W2087533476 creator A5037231921 @default.
• W2087533476 creator A5045445172 @default.
• W2087533476 creator A5065050442 @default.
• W2087533476 creator A5069913800 @default.
• W2087533476 creator A5070951824 @default.
• W2087533476 creator A5072645559 @default.
• W2087533476 creator A5075845581 @default.
• W2087533476 date "2007-07-31" @default.
• W2087533476 modified "2023-10-16" @default.
• W2087533476 title "Expression changes of hippocampal energy metabolism enzymes contribute to behavioural abnormalities during chronic morphine treatment" @default.
• W2087533476 cites W1948495312 @default.
• W2087533476 cites W1964865761 @default.
• W2087533476 cites W1969464152 @default.
• W2087533476 cites W1969633895 @default.
• W2087533476 cites W1973036887 @default.
• W2087533476 cites W1976307708 @default.
• W2087533476 cites W1978009313 @default.
• W2087533476 cites W1981593008 @default.
• W2087533476 cites W1982945301 @default.
• W2087533476 cites W1990199205 @default.
• W2087533476 cites W1992886240 @default.
• W2087533476 cites W1996016459 @default.
• W2087533476 cites W2007611402 @default.
• W2087533476 cites W2008844555 @default.
• W2087533476 cites W2010271493 @default.
• W2087533476 cites W2022324525 @default.
• W2087533476 cites W2023079553 @default.
• W2087533476 cites W2025801062 @default.
• W2087533476 cites W2031461849 @default.
• W2087533476 cites W2031735886 @default.
• W2087533476 cites W2042615161 @default.
• W2087533476 cites W2043225087 @default.
• W2087533476 cites W2057831654 @default.
• W2087533476 cites W2064094695 @default.
• W2087533476 cites W2068250844 @default.
• W2087533476 cites W2069550725 @default.
• W2087533476 cites W2070572428 @default.
• W2087533476 cites W2078526156 @default.
• W2087533476 cites W2080570858 @default.
• W2087533476 cites W2080784536 @default.
• W2087533476 cites W2084793623 @default.
• W2087533476 cites W2085155996 @default.
• W2087533476 cites W2086156157 @default.
• W2087533476 cites W2090473934 @default.
• W2087533476 cites W2090876558 @default.
• W2087533476 cites W2104934836 @default.
• W2087533476 cites W2108747869 @default.
• W2087533476 cites W2113247978 @default.
• W2087533476 cites W2113460545 @default.
• W2087533476 cites W2120442436 @default.
• W2087533476 cites W2125619659 @default.
• W2087533476 cites W2131651771 @default.
• W2087533476 cites W2136792753 @default.
• W2087533476 cites W2164730568 @default.
• W2087533476 cites W2165004755 @default.
• W2087533476 cites W775019103 @default.
• W2087533476 doi "https://doi.org/10.1038/cr.2007.63" @default.
• W2087533476 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17667915" @default.
• W2087533476 hasPublicationYear "2007" @default.
• W2087533476 type Work @default.
• W2087533476 sameAs 2087533476 @default.
• W2087533476 citedByCount "38" @default.
• W2087533476 countsByYear W20875334762012 @default.
• W2087533476 countsByYear W20875334762013 @default.
• W2087533476 countsByYear W20875334762014 @default.
• W2087533476 countsByYear W20875334762015 @default.
• W2087533476 countsByYear W20875334762016 @default.
• W2087533476 countsByYear W20875334762017 @default.
• W2087533476 countsByYear W20875334762018 @default.
• W2087533476 countsByYear W20875334762019 @default.
• W2087533476 countsByYear W20875334762020 @default.
• W2087533476 countsByYear W20875334762021 @default.
• W2087533476 countsByYear W20875334762022 @default.
• W2087533476 countsByYear W20875334762023 @default.
• W2087533476 crossrefType "journal-article" @default.
• W2087533476 hasAuthorship W2087533476A5010479652 @default.
• W2087533476 hasAuthorship W2087533476A5019131179 @default.
• W2087533476 hasAuthorship W2087533476A5027256159 @default.
• W2087533476 hasAuthorship W2087533476A5037231921 @default.
• W2087533476 hasAuthorship W2087533476A5045445172 @default.
• W2087533476 hasAuthorship W2087533476A5065050442 @default.
• W2087533476 hasAuthorship W2087533476A5069913800 @default.
• W2087533476 hasAuthorship W2087533476A5070951824 @default.
• W2087533476 hasAuthorship W2087533476A5072645559 @default.
• W2087533476 hasAuthorship W2087533476A5075845581 @default.
• W2087533476 hasBestOaLocation W20875334761 @default.
• W2087533476 hasConcept C104317684 @default.
• W2087533476 hasConcept C126322002 @default.
• W2087533476 hasConcept C127561419 @default.
• W2087533476 hasConcept C134018914 @default.
• W2087533476 hasConcept C148762608 @default.
• W2087533476 hasConcept C169760540 @default.
• W2087533476 hasConcept C169900460 @default.

• next