Matches in SemOpenAlex for { <https://semopenalex.org/work/W2087533786> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2087533786 endingPage "282" @default.
- W2087533786 startingPage "277" @default.
- W2087533786 abstract "To study the relationship between the methylation status of multi-drug resistance protein (MRP) gene and the expression of its mRNA and protein in lung cancer cell lines. Human embryo lung cell line WI-38, lung adenocarcinoma cell line SPCA-1 and its drug-resistant cells induced by different concentrations of doxorubicin were treated with restriction endonuclease Eco47III. The methylation status of MRP was examined by PCR, and the expressions of its mRNA and protein were evaluated by in situ hybridization and immunohistochemistry. MRP gene promoter region of WI-38 cells was in hypermethylation status, but the promoter region of MRP in SPCA-1 cells and their resistant derivatives induced by different concentrations of doxorubicin were in hypomethylation status. There were significant differences in the expression of MRP mRNA among WI-38 cell line, SPCA-1 cells and their drug-resistant derivatives induced by different concentration of doxorubicin. Consistently, MRP immunostaining presented similar significant differences. The promoter region of MRP in SPCA-1 lung adenocarcinoma cells was in hypomethylation status. The hypomethylation status of 5′ regulatory region of MRP promoter is an important structural basis that can increase the activity of transcription and results in the development of drug resistance in lung cancer." @default.
- W2087533786 created "2016-06-24" @default.
- W2087533786 creator A5060497159 @default.
- W2087533786 creator A5065665452 @default.
- W2087533786 date "2007-12-01" @default.
- W2087533786 modified "2023-09-26" @default.
- W2087533786 title "Relationship between methylation status of multi-drug resistance protein(MRP) and multi-drug resistance in lung cancer cell lines" @default.
- W2087533786 cites W1985531970 @default.
- W2087533786 cites W2002766974 @default.
- W2087533786 cites W2017508710 @default.
- W2087533786 cites W2052848470 @default.
- W2087533786 cites W2075284437 @default.
- W2087533786 cites W2124418078 @default.
- W2087533786 cites W2129940569 @default.
- W2087533786 cites W2133478283 @default.
- W2087533786 cites W2153487848 @default.
- W2087533786 cites W2155621857 @default.
- W2087533786 cites W11517865 @default.
- W2087533786 doi "https://doi.org/10.1007/s11670-007-0277-0" @default.
- W2087533786 hasPublicationYear "2007" @default.
- W2087533786 type Work @default.
- W2087533786 sameAs 2087533786 @default.
- W2087533786 citedByCount "0" @default.
- W2087533786 crossrefType "journal-article" @default.
- W2087533786 hasAuthorship W2087533786A5060497159 @default.
- W2087533786 hasAuthorship W2087533786A5065665452 @default.
- W2087533786 hasConcept C104317684 @default.
- W2087533786 hasConcept C105580179 @default.
- W2087533786 hasConcept C114851261 @default.
- W2087533786 hasConcept C121608353 @default.
- W2087533786 hasConcept C142724271 @default.
- W2087533786 hasConcept C1491633281 @default.
- W2087533786 hasConcept C150194340 @default.
- W2087533786 hasConcept C153911025 @default.
- W2087533786 hasConcept C190727270 @default.
- W2087533786 hasConcept C2776256026 @default.
- W2087533786 hasConcept C2776694085 @default.
- W2087533786 hasConcept C2781182431 @default.
- W2087533786 hasConcept C2781303535 @default.
- W2087533786 hasConcept C33288867 @default.
- W2087533786 hasConcept C502942594 @default.
- W2087533786 hasConcept C54355233 @default.
- W2087533786 hasConcept C55493867 @default.
- W2087533786 hasConcept C71924100 @default.
- W2087533786 hasConcept C81885089 @default.
- W2087533786 hasConcept C86803240 @default.
- W2087533786 hasConceptScore W2087533786C104317684 @default.
- W2087533786 hasConceptScore W2087533786C105580179 @default.
- W2087533786 hasConceptScore W2087533786C114851261 @default.
- W2087533786 hasConceptScore W2087533786C121608353 @default.
- W2087533786 hasConceptScore W2087533786C142724271 @default.
- W2087533786 hasConceptScore W2087533786C1491633281 @default.
- W2087533786 hasConceptScore W2087533786C150194340 @default.
- W2087533786 hasConceptScore W2087533786C153911025 @default.
- W2087533786 hasConceptScore W2087533786C190727270 @default.
- W2087533786 hasConceptScore W2087533786C2776256026 @default.
- W2087533786 hasConceptScore W2087533786C2776694085 @default.
- W2087533786 hasConceptScore W2087533786C2781182431 @default.
- W2087533786 hasConceptScore W2087533786C2781303535 @default.
- W2087533786 hasConceptScore W2087533786C33288867 @default.
- W2087533786 hasConceptScore W2087533786C502942594 @default.
- W2087533786 hasConceptScore W2087533786C54355233 @default.
- W2087533786 hasConceptScore W2087533786C55493867 @default.
- W2087533786 hasConceptScore W2087533786C71924100 @default.
- W2087533786 hasConceptScore W2087533786C81885089 @default.
- W2087533786 hasConceptScore W2087533786C86803240 @default.
- W2087533786 hasIssue "4" @default.
- W2087533786 hasLocation W20875337861 @default.
- W2087533786 hasOpenAccess W2087533786 @default.
- W2087533786 hasPrimaryLocation W20875337861 @default.
- W2087533786 hasRelatedWork W1519915707 @default.
- W2087533786 hasRelatedWork W1603166532 @default.
- W2087533786 hasRelatedWork W1969774671 @default.
- W2087533786 hasRelatedWork W2794651804 @default.
- W2087533786 hasRelatedWork W2904515903 @default.
- W2087533786 hasRelatedWork W2991864465 @default.
- W2087533786 hasRelatedWork W3086917908 @default.
- W2087533786 hasRelatedWork W3118746383 @default.
- W2087533786 hasRelatedWork W3143151884 @default.
- W2087533786 hasRelatedWork W4283027398 @default.
- W2087533786 hasVolume "19" @default.
- W2087533786 isParatext "false" @default.
- W2087533786 isRetracted "false" @default.
- W2087533786 magId "2087533786" @default.
- W2087533786 workType "article" @default.