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• W2087548891 abstract "Abstract Aim. Cerebrovascular disease is the most commonly encountered condition which causes serious mortality and morbidity in neurological practice. It has been reported that heart rate variability declines in a cerebrovasculer disease, which shows that autonomic functions are affected. Autonomic nervous system has a significant role in monitoring immune status and controlling inflammation. Similarly, there are studies reporting that immune system is affected during acute phase of cerebrovascular diseases. In the present study, our aim was to investigate the effect of autonomic nervous system on immune response and prognosis in acute ischemic cerebrovascular diseases. Method. 44 patients with middle cerebral artery infarction and 44 healthy controls were included in this study. Autonomic nervous system was evaluated using a methodology analysing the heart rate variability based on frequency. In order to evaluate the effects on immun system, serum levels of interleukin 1 β , interleukin 6, tumor necrosis factor alfa and interleukin 10 were measured on the 1 st , 3 rd , 7 th and 10 th day by ELISA. Prognosis was evaluated by Rankin scale after 3 months. Results. Compared to the controls, low frequency power in normalized units (LFnu) was found to be high, high frequency power in normalized units (HFnu) was found to be low and ratio of LFnu/HFnu was found to be high in the patients group. The increase being more marked in left middle cerebral artery infarctions, interleukin-6 level were increased on the 10 th day and interleukin-10 level was decreased at all days compared to baseline in all patients. I nterleukin- 1β and tumor necrosis factor α levels were lower in all patients but the decrease was more pronounced in patients having left middle cerebral artery infarction. There was no difference between the Rankin scores of the patients having right and left mi d dle cerebral artery infarction. Conclusions. Ischemic cerebrovascul a r disease is associated with an effect on immune system. This impaired immun response can be correlated both with a decreased parasympathetic activity and an increased sympathetic activity particularly in patients with middle cerebral artery infarctions. Keywords: Stroke, heart rate variability, interleukin-1 β , interleukin-6, interleukin-10, tumor necrosis factor alfa Ozet Amac. Serebrovaskuler hastalik noroloji pratiginde en sik karsilasilan ve ciddi morbidite ve mortaliteye sebep olan bir durumdur. Serebrovaskuler hastalikta otonom fonksiyonlarda etkilenmeyi gosteren kalp hizi degiskenliginde azalma oldugu bildirilmektedir. Otonom sinir sistemi immun durumun monitorize edilmesinde ve inflamasyonun kontrolunde onemli rol oynar. Benzer sekilde serebrovaskuler hastaliklarin akut doneminde immun sistemin de etkilendigini gosteren calismalar mevcuttur. Amacimiz akut iskemik serebrovaskuler hastaliklarda otonom sinir sistemi fonksiyonunun immun yanit ve prognoza etkisini arastirmaktir. Yontem. Calismaya orta serebral arter infarkti olan 44 hasta ve 44 saglikli birey alinmistir. Otonom sinir sistemi frekansa dayali kalp hizi degiskenligi analiz yontemiyle degerlendirilmistir. Immun sistem etkilenmesi degerlendirmede 1, 3, 7 ve 10. gunlerde ELISA yontemiyle serum interlokin-1β, interlokin-6, tumor nekrozis faktor α ve interlokin-10 duzeyleri calisildi. Prognoz 3 ay sonra Rankin skoru ile degerlendirildi. Bulgular. Hastalarda kontrollerle karsilastirildiginda Dusuk Frekansli Guc Normalize Unit (LFnu) yuksek, Yuksek Frekansli Guc Normalize Unit (HFnu) dusuk ve LFnu/HFnu orani ise yuksek bulundu. Sol orta serebral arter infaktlarinda daha belirgin olmak uzere tum hastalarda 10. gunde Interlokin-6 seviyesinde artis, Interlokin-10 seviyesinde ise baslangictan itibaren tum gunlerde dusus goruldu. Interlokin-1β ve tumor nekrozis faktor α seviyeleri sol orta serebral arter infaktlarinda daha belirgin olmak uzere tum hastalarda dusuktu. Rankin skorlari arasinda farklilik bulunmadi. Sonuc. Iskemik serebrovaskuler hastalik immun sistem etkilenmesi ile birliktedir. Ozellikle orta serebral arter infaktlarinda ortaya cikan bu bozulmus immun yanit, azalmis parasempatik aktivite yaninda artmis sempatik aktiviteyle iliskilendirilebilir. Anahtar sozcukler: Inme, kalp hizi degiskenligi, interlokin-1β, i nterlokin-6, i nterlokin-10, tumor nekrozis faktor α" @default.
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• W2087548891 date "2012-05-12" @default.
• W2087548891 modified "2023-09-25" @default.
• W2087548891 title "Association of autonomic nervous system functions with immune response and prognosis in acute ischemic stroke patients" @default.
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• W2087548891 doi "https://doi.org/10.7197/cmj.v34i4.1008001558" @default.
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