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• W2087555663 abstract "CLIC4 (chloride intracellular channel 4), a multifunctional protein that traffics between the cytoplasm and nucleus, interacts with Schnurri-2, a transcription factor in the bone morphogenetic protein (BMP) signalling pathway. Here we show that transforming growth factor beta (TGF-beta) promotes the expression of CLIC4 and Schnurri-2 as well as their association in the cytoplasm and their translocation to the nucleus. In the absence of CLIC4 or Schnurri-2, TGF-beta signalling is abrogated. Direct nuclear targeting of CLIC4 enhances TGF-beta signalling and removes the requirement for Schnurri-2. Nuclear CLIC4 associates with phospho (p)-Smad2 and p-Smad3, protecting them from dephosphorylation by nuclear phosphatases. An intact TGF-beta signalling pathway is essential for CLIC4-mediated growth-arrest. These results newly identify Schnurri-2 and CLIC4 as modifiers of TGF-beta signalling through their stabilization of p-Smad2 and 3 in the nucleus." @default.
• W2087555663 created "2016-06-24" @default.
• W2087555663 creator A5010373481 @default.
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• W2087555663 date "2009-05-17" @default.
• W2087555663 modified "2023-10-01" @default.
• W2087555663 title "TGF-β signalling is regulated by Schnurri-2-dependent nuclear translocation of CLIC4 and consequent stabilization of phospho-Smad2 and 3" @default.
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• W2087555663 doi "https://doi.org/10.1038/ncb1885" @default.
• W2087555663 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2825893" @default.
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