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- W2087563064 abstract "Four genes, fagA, B, C and D, encoding products with 32-47% identity to proteins involved in bacterial iron uptake systems, were identified immediately downstream of the Corynebacterium pseudotuberculosis phospholipase D gene. beta-Galactosidase assays on a C. pseudotuberculosis strain carrying a fagA-lacZ fusion indicated that the putative fagABC operon was poorly expressed in iron-rich media. However, similar experiments in iron-limited media resulted in an approximately three-fold increase in beta-galactosidase activity, suggesting that this operon is regulated by iron in vitro. Although no defect in iron utilization could be determined for a C. pseudotuberculosis fagB(C) mutant in vitro, this mutant showed reduced virulence compared to wild-type in a goat model of caseous lymphadenitis. Thus, expression of the fag genes in the host appears to contribute to virulence." @default.
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- W2087563064 date "2002-02-01" @default.
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- W2087563064 title "Identification and role in virulence of putative iron acquisition genes from<i>Corynebacterium pseudotuberculosis</i>" @default.
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- W2087563064 doi "https://doi.org/10.1111/j.1574-6968.2002.tb11058.x" @default.
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