Matches in SemOpenAlex for { <https://semopenalex.org/work/W2087566102> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2087566102 endingPage "140" @default.
- W2087566102 startingPage "129" @default.
- W2087566102 abstract "Summary— We have studied the effects of middle cerebral artery (MCA) occlusion in rats on polyamine efflux in the parietal cortex using the microdialysis technique. Dialysis probe implantation itself provoked a delayed, prolonged and vigorous release of spermidine and putrescine. Spermidine release returned to stable baseline levels within 48 hours. Putrescine release also returned to lower levels within this time period but putrescine levels in the dialysate fluctuated dramatically in individual animals. Because of the underlying effects of the dialysis probe (likely a reflection of traumatic cerebral damage and stimulation of polyamine metabolism and release within the immediate vicinity of the dialysis probe), MCA occlusion was performed 48 hours after probe implantation. MCA occlusion persistently (5/5 animals) resulted in a significant increase in cortical spermidine efflux, although the onset, magnitude and duration of this increased release was variable. Putrescine efflux was significantly increased in 2/5 animals with MCA occlusion but the increase in release was similar to the spontaneous fluctuations observed in control animals. Spermine was not detectable in cortical dialysates of control or MCA occluded groups. Spermidine, but not spermine or putrescine is consistently released from the parietal cortex following permanent focal ischaemia and may contribute to ischaemic neuropathology either through its effects at the N-methyl-D-aspartate (NMDA) receptor or via direct, and as yet uncharacterised, neurotoxic effects." @default.
- W2087566102 created "2016-06-24" @default.
- W2087566102 creator A5000584525 @default.
- W2087566102 creator A5031707222 @default.
- W2087566102 creator A5044773978 @default.
- W2087566102 creator A5065591303 @default.
- W2087566102 creator A5088779378 @default.
- W2087566102 creator A5089194350 @default.
- W2087566102 date "1995-03-04" @default.
- W2087566102 modified "2023-09-27" @default.
- W2087566102 title "Release of spermidine from the rat cortex following permanent middle cerebral artery occlusion" @default.
- W2087566102 cites W1965405447 @default.
- W2087566102 cites W1968230977 @default.
- W2087566102 cites W1968885461 @default.
- W2087566102 cites W1976374076 @default.
- W2087566102 cites W1982445266 @default.
- W2087566102 cites W1982860812 @default.
- W2087566102 cites W1996838864 @default.
- W2087566102 cites W2003767305 @default.
- W2087566102 cites W2008808481 @default.
- W2087566102 cites W2030574405 @default.
- W2087566102 cites W2031797805 @default.
- W2087566102 cites W2037220946 @default.
- W2087566102 cites W2042228814 @default.
- W2087566102 cites W2048242804 @default.
- W2087566102 cites W2066650835 @default.
- W2087566102 cites W2089834973 @default.
- W2087566102 cites W2094749887 @default.
- W2087566102 cites W2155885439 @default.
- W2087566102 doi "https://doi.org/10.1111/j.1472-8206.1995.tb00272.x" @default.
- W2087566102 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7628825" @default.
- W2087566102 hasPublicationYear "1995" @default.
- W2087566102 type Work @default.
- W2087566102 sameAs 2087566102 @default.
- W2087566102 citedByCount "18" @default.
- W2087566102 crossrefType "journal-article" @default.
- W2087566102 hasAuthorship W2087566102A5000584525 @default.
- W2087566102 hasAuthorship W2087566102A5031707222 @default.
- W2087566102 hasAuthorship W2087566102A5044773978 @default.
- W2087566102 hasAuthorship W2087566102A5065591303 @default.
- W2087566102 hasAuthorship W2087566102A5088779378 @default.
- W2087566102 hasAuthorship W2087566102A5089194350 @default.
- W2087566102 hasConcept C126322002 @default.
- W2087566102 hasConcept C134018914 @default.
- W2087566102 hasConcept C181199279 @default.
- W2087566102 hasConcept C185592680 @default.
- W2087566102 hasConcept C2775841333 @default.
- W2087566102 hasConcept C2776109719 @default.
- W2087566102 hasConcept C2776268601 @default.
- W2087566102 hasConcept C2777167505 @default.
- W2087566102 hasConcept C2777497464 @default.
- W2087566102 hasConcept C2780115381 @default.
- W2087566102 hasConcept C2781041448 @default.
- W2087566102 hasConcept C42219234 @default.
- W2087566102 hasConcept C50156730 @default.
- W2087566102 hasConcept C529278444 @default.
- W2087566102 hasConcept C541997718 @default.
- W2087566102 hasConcept C55493867 @default.
- W2087566102 hasConcept C71924100 @default.
- W2087566102 hasConceptScore W2087566102C126322002 @default.
- W2087566102 hasConceptScore W2087566102C134018914 @default.
- W2087566102 hasConceptScore W2087566102C181199279 @default.
- W2087566102 hasConceptScore W2087566102C185592680 @default.
- W2087566102 hasConceptScore W2087566102C2775841333 @default.
- W2087566102 hasConceptScore W2087566102C2776109719 @default.
- W2087566102 hasConceptScore W2087566102C2776268601 @default.
- W2087566102 hasConceptScore W2087566102C2777167505 @default.
- W2087566102 hasConceptScore W2087566102C2777497464 @default.
- W2087566102 hasConceptScore W2087566102C2780115381 @default.
- W2087566102 hasConceptScore W2087566102C2781041448 @default.
- W2087566102 hasConceptScore W2087566102C42219234 @default.
- W2087566102 hasConceptScore W2087566102C50156730 @default.
- W2087566102 hasConceptScore W2087566102C529278444 @default.
- W2087566102 hasConceptScore W2087566102C541997718 @default.
- W2087566102 hasConceptScore W2087566102C55493867 @default.
- W2087566102 hasConceptScore W2087566102C71924100 @default.
- W2087566102 hasIssue "2" @default.
- W2087566102 hasLocation W20875661021 @default.
- W2087566102 hasLocation W20875661022 @default.
- W2087566102 hasOpenAccess W2087566102 @default.
- W2087566102 hasPrimaryLocation W20875661021 @default.
- W2087566102 hasRelatedWork W117942809 @default.
- W2087566102 hasRelatedWork W2031199125 @default.
- W2087566102 hasRelatedWork W2037220946 @default.
- W2087566102 hasRelatedWork W2053396064 @default.
- W2087566102 hasRelatedWork W2055652088 @default.
- W2087566102 hasRelatedWork W2097791331 @default.
- W2087566102 hasRelatedWork W2153768364 @default.
- W2087566102 hasRelatedWork W2350408912 @default.
- W2087566102 hasRelatedWork W328716559 @default.
- W2087566102 hasRelatedWork W3142885399 @default.
- W2087566102 hasVolume "9" @default.
- W2087566102 isParatext "false" @default.
- W2087566102 isRetracted "false" @default.
- W2087566102 magId "2087566102" @default.
- W2087566102 workType "article" @default.