FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2087578657> ?p ?o ?g. }

• W2087578657 endingPage "205" @default.
• W2087578657 startingPage "196" @default.
• W2087578657 abstract "Background— Ligands activating the transcription factor peroxisome proliferator–activated receptor-γ (PPARγ) have antiinflammatory effects. Vascular rejection induced by allogeneic T cells can be responsible for acute and chronic graft loss. Studies in rodents suggest that PPARγ agonists may inhibit graft vascular rejection, but human T-cell responses to allogeneic vascular cells differ from those in rodents, and the effects of PPARγ in human transplantation are unknown. Methods and Results— We tested the effects of PPARγ agonists on human vascular graft rejection using a model in which human artery is interposed into the abdominal aorta of immunodeficient mice, followed by adoptive transfer of allogeneic (to the artery donor) human peripheral blood mononuclear cells. Interferon-γ–dependent rejection ensues within 4 weeks, characterized by intimal thickening, T-cell infiltrates, and vascular cell activation, a response resembling clinical intimal arteritis. The PPARγ agonists 15-deoxy-prostaglandin-J 2 , ciglitazone, and pioglitazone reduced intimal expansion, intimal infiltration of CD45RO + memory T cells, and plasma levels of inflammatory cytokines. The PPARγ antagonist GW9662 reversed the protective effects of PPARγ agonists, confirming the involvement of PPARγ-mediated pathways. In vitro, pioglitazone inhibited both alloantigen-induced proliferation and superantigen-induced transendothelial migration of memory T cells, indicating the potential mechanisms of PPARγ effects. Conclusion— Our results suggest that PPARγ agonists inhibit allogeneic human memory T cell responses and may be useful for the treatment of vascular graft rejection." @default.
• W2087578657 created "2016-06-24" @default.
• W2087578657 creator A5005814078 @default.
• W2087578657 creator A5006861896 @default.
• W2087578657 creator A5007352128 @default.
• W2087578657 creator A5022235365 @default.
• W2087578657 creator A5028806508 @default.
• W2087578657 creator A5036202065 @default.
• W2087578657 creator A5040021656 @default.
• W2087578657 creator A5045255768 @default.
• W2087578657 creator A5055641686 @default.
• W2087578657 creator A5068154276 @default.
• W2087578657 creator A5075375354 @default.
• W2087578657 creator A5075400262 @default.
• W2087578657 creator A5077447040 @default.
• W2087578657 date "2011-07-12" @default.
• W2087578657 modified "2023-10-18" @default.
• W2087578657 title "Peroxisome Proliferator–Activated Receptor-γ Agonists Prevent In Vivo Remodeling of Human Artery Induced by Alloreactive T Cells" @default.
• W2087578657 cites W1523840697 @default.
• W2087578657 cites W1560649513 @default.
• W2087578657 cites W1586898108 @default.
• W2087578657 cites W1598147941 @default.
• W2087578657 cites W1656162023 @default.
• W2087578657 cites W1916337192 @default.
• W2087578657 cites W1955442983 @default.
• W2087578657 cites W1956616902 @default.
• W2087578657 cites W1968973887 @default.
• W2087578657 cites W1971895216 @default.
• W2087578657 cites W1981568036 @default.
• W2087578657 cites W1982707127 @default.
• W2087578657 cites W1993694317 @default.
• W2087578657 cites W1994659489 @default.
• W2087578657 cites W1995234326 @default.
• W2087578657 cites W2000520103 @default.
• W2087578657 cites W2005139170 @default.
• W2087578657 cites W2006561971 @default.
• W2087578657 cites W2014017592 @default.
• W2087578657 cites W2017645978 @default.
• W2087578657 cites W2020319376 @default.
• W2087578657 cites W2023239847 @default.
• W2087578657 cites W2027488189 @default.
• W2087578657 cites W2035402287 @default.
• W2087578657 cites W2039193485 @default.
• W2087578657 cites W2053685914 @default.
• W2087578657 cites W2054501376 @default.
• W2087578657 cites W2056207471 @default.
• W2087578657 cites W2064617441 @default.
• W2087578657 cites W2066361083 @default.
• W2087578657 cites W2072734854 @default.
• W2087578657 cites W2075064273 @default.
• W2087578657 cites W2075080580 @default.
• W2087578657 cites W2084776016 @default.
• W2087578657 cites W2085241267 @default.
• W2087578657 cites W2088868476 @default.
• W2087578657 cites W2089687829 @default.
• W2087578657 cites W2094907236 @default.
• W2087578657 cites W2100750761 @default.
• W2087578657 cites W2104388996 @default.
• W2087578657 cites W2110360170 @default.
• W2087578657 cites W2123093300 @default.
• W2087578657 cites W2127622386 @default.
• W2087578657 cites W2149287982 @default.
• W2087578657 cites W2168662912 @default.
• W2087578657 cites W2168854306 @default.
• W2087578657 cites W2397547693 @default.
• W2087578657 cites W4242872472 @default.
• W2087578657 doi "https://doi.org/10.1161/circulationaha.110.015396" @default.
• W2087578657 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3347886" @default.
• W2087578657 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21690493" @default.
• W2087578657 hasPublicationYear "2011" @default.
• W2087578657 type Work @default.
• W2087578657 sameAs 2087578657 @default.
• W2087578657 citedByCount "20" @default.
• W2087578657 countsByYear W20875786572012 @default.
• W2087578657 countsByYear W20875786572013 @default.
• W2087578657 countsByYear W20875786572014 @default.
• W2087578657 countsByYear W20875786572015 @default.
• W2087578657 countsByYear W20875786572016 @default.
• W2087578657 countsByYear W20875786572017 @default.
• W2087578657 countsByYear W20875786572018 @default.
• W2087578657 countsByYear W20875786572019 @default.
• W2087578657 countsByYear W20875786572022 @default.
• W2087578657 crossrefType "journal-article" @default.
• W2087578657 hasAuthorship W2087578657A5005814078 @default.
• W2087578657 hasAuthorship W2087578657A5006861896 @default.
• W2087578657 hasAuthorship W2087578657A5007352128 @default.
• W2087578657 hasAuthorship W2087578657A5022235365 @default.
• W2087578657 hasAuthorship W2087578657A5028806508 @default.
• W2087578657 hasAuthorship W2087578657A5036202065 @default.
• W2087578657 hasAuthorship W2087578657A5040021656 @default.
• W2087578657 hasAuthorship W2087578657A5045255768 @default.
• W2087578657 hasAuthorship W2087578657A5055641686 @default.
• W2087578657 hasAuthorship W2087578657A5068154276 @default.
• W2087578657 hasAuthorship W2087578657A5075375354 @default.
• W2087578657 hasAuthorship W2087578657A5075400262 @default.
• W2087578657 hasAuthorship W2087578657A5077447040 @default.
• W2087578657 hasBestOaLocation W20875786571 @default.
• W2087578657 hasConcept C126322002 @default.

• next