FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2087586442> ?p ?o ?g. }

• W2087586442 endingPage "18267" @default.
• W2087586442 startingPage "18262" @default.
• W2087586442 abstract "Efficient transmission of Plasmodium species between humans and Anopheles mosquitoes is a major contributor to the global burden of malaria. Gametocytogenesis, the process by which parasites switch from asexual replication within human erythrocytes to produce male and female gametocytes, is a critical step in malaria transmission and Plasmodium genetic diversity. Nothing is known about the pathways that regulate gametocytogenesis and only few of the current drugs that inhibit asexual replication are also capable of inhibiting gametocyte development and blocking malaria transmission. Here we provide genetic and pharmacological evidence indicating that the pathway for synthesis of phosphatidylcholine in Plasmodium falciparum membranes from host serine is essential for parasite gametocytogenesis and malaria transmission. Parasites lacking the phosphoethanolamine N-methyltransferase enzyme, which catalyzes the limiting step in this pathway, are severely altered in gametocyte development, are incapable of producing mature-stage gametocytes, and are not transmitted to mosquitoes. Chemical screening identified 11 inhibitors of phosphoethanolamine N-methyltransferase that block parasite intraerythrocytic asexual replication and gametocyte differentiation in the low micromolar range. Kinetic studies in vitro as well as functional complementation assays and lipid metabolic analyses in vivo on the most promising inhibitor NSC-158011 further demonstrated the specificity of inhibition. These studies set the stage for further optimization of NSC-158011 for development of a class of dual activity antimalarials to block both intraerythrocytic asexual replication and gametocytogenesis." @default.
• W2087586442 created "2016-06-24" @default.
• W2087586442 creator A5001519174 @default.
• W2087586442 creator A5008481640 @default.
• W2087586442 creator A5010280896 @default.
• W2087586442 creator A5011416577 @default.
• W2087586442 creator A5022173812 @default.
• W2087586442 creator A5032571886 @default.
• W2087586442 creator A5035425027 @default.
• W2087586442 creator A5037123765 @default.
• W2087586442 creator A5044700206 @default.
• W2087586442 creator A5045963843 @default.
• W2087586442 creator A5049888866 @default.
• W2087586442 creator A5052648787 @default.
• W2087586442 creator A5056105029 @default.
• W2087586442 creator A5071314941 @default.
• W2087586442 creator A5075673156 @default.
• W2087586442 creator A5080561555 @default.
• W2087586442 date "2013-10-21" @default.
• W2087586442 modified "2023-09-24" @default.
• W2087586442 title "<i>Plasmodium falciparum</i> phosphoethanolamine methyltransferase is essential for malaria transmission" @default.
• W2087586442 cites W1588347494 @default.
• W2087586442 cites W1595781572 @default.
• W2087586442 cites W1968876624 @default.
• W2087586442 cites W1969503178 @default.
• W2087586442 cites W1972810184 @default.
• W2087586442 cites W1990392794 @default.
• W2087586442 cites W2009784355 @default.
• W2087586442 cites W2020251171 @default.
• W2087586442 cites W2033203808 @default.
• W2087586442 cites W2035888977 @default.
• W2087586442 cites W2064163449 @default.
• W2087586442 cites W2068585157 @default.
• W2087586442 cites W2069995906 @default.
• W2087586442 cites W2101792514 @default.
• W2087586442 cites W2115357182 @default.
• W2087586442 cites W2122753628 @default.
• W2087586442 cites W2134089325 @default.
• W2087586442 cites W2135374912 @default.
• W2087586442 cites W2143355874 @default.
• W2087586442 cites W2147240769 @default.
• W2087586442 cites W2149575909 @default.
• W2087586442 cites W2162195177 @default.
• W2087586442 doi "https://doi.org/10.1073/pnas.1313965110" @default.
• W2087586442 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3831454" @default.
• W2087586442 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24145416" @default.
• W2087586442 hasPublicationYear "2013" @default.
• W2087586442 type Work @default.
• W2087586442 sameAs 2087586442 @default.
• W2087586442 citedByCount "60" @default.
• W2087586442 countsByYear W20875864422013 @default.
• W2087586442 countsByYear W20875864422014 @default.
• W2087586442 countsByYear W20875864422015 @default.
• W2087586442 countsByYear W20875864422016 @default.
• W2087586442 countsByYear W20875864422017 @default.
• W2087586442 countsByYear W20875864422018 @default.
• W2087586442 countsByYear W20875864422019 @default.
• W2087586442 countsByYear W20875864422020 @default.
• W2087586442 countsByYear W20875864422021 @default.
• W2087586442 countsByYear W20875864422022 @default.
• W2087586442 countsByYear W20875864422023 @default.
• W2087586442 crossrefType "journal-article" @default.
• W2087586442 hasAuthorship W2087586442A5001519174 @default.
• W2087586442 hasAuthorship W2087586442A5008481640 @default.
• W2087586442 hasAuthorship W2087586442A5010280896 @default.
• W2087586442 hasAuthorship W2087586442A5011416577 @default.
• W2087586442 hasAuthorship W2087586442A5022173812 @default.
• W2087586442 hasAuthorship W2087586442A5032571886 @default.
• W2087586442 hasAuthorship W2087586442A5035425027 @default.
• W2087586442 hasAuthorship W2087586442A5037123765 @default.
• W2087586442 hasAuthorship W2087586442A5044700206 @default.
• W2087586442 hasAuthorship W2087586442A5045963843 @default.
• W2087586442 hasAuthorship W2087586442A5049888866 @default.
• W2087586442 hasAuthorship W2087586442A5052648787 @default.
• W2087586442 hasAuthorship W2087586442A5056105029 @default.
• W2087586442 hasAuthorship W2087586442A5071314941 @default.
• W2087586442 hasAuthorship W2087586442A5075673156 @default.
• W2087586442 hasAuthorship W2087586442A5080561555 @default.
• W2087586442 hasBestOaLocation W20875864421 @default.
• W2087586442 hasConcept C136764020 @default.
• W2087586442 hasConcept C159047783 @default.
• W2087586442 hasConcept C203014093 @default.
• W2087586442 hasConcept C2778048844 @default.
• W2087586442 hasConcept C2778371730 @default.
• W2087586442 hasConcept C2778675580 @default.
• W2087586442 hasConcept C2781375639 @default.
• W2087586442 hasConcept C41008148 @default.
• W2087586442 hasConcept C54355233 @default.
• W2087586442 hasConcept C71928629 @default.
• W2087586442 hasConcept C86803240 @default.
• W2087586442 hasConcept C99389464 @default.
• W2087586442 hasConceptScore W2087586442C136764020 @default.
• W2087586442 hasConceptScore W2087586442C159047783 @default.
• W2087586442 hasConceptScore W2087586442C203014093 @default.
• W2087586442 hasConceptScore W2087586442C2778048844 @default.
• W2087586442 hasConceptScore W2087586442C2778371730 @default.
• W2087586442 hasConceptScore W2087586442C2778675580 @default.
• W2087586442 hasConceptScore W2087586442C2781375639 @default.

• next