FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2087589470> ?p ?o ?g. }

• W2087589470 endingPage "445" @default.
• W2087589470 startingPage "433" @default.
• W2087589470 abstract "Cyclic AMP is a major trigger of the differentiation process of Trypanosoma brucei, a bloodstream parasite causing sleeping sickness. Its generation in trypanosomes is accomplished by a unique battery of membrane-bound adenylate cyclases (ACs). We have determined the high-resolution X-ray structures of the catalytic domains of two trypanosomal ACs (tACs), GRESAG4.1 and GRESAG4.3. The tAC domains are structurally highly related to the AC domains of higher eukaryotes, but also comprise a highly conserved structural element near the active site, the Delta-subdomain. A cavity below the Delta-subdomain might correspond to an allosteric regulator site as indicated by the stereospecific binding of a single (2S,3S)-1,4- dimercapto-2,3-butanediol molecule. In three different crystal forms, the tAC domains are exclusively observed in a monomeric, catalytically inactive state. Biochemical analysis and the mutagenesis profile of GRESAG4.1 confirmed a common catalytic mechanism of tACs that involves transient dimerization of the AC domain. A low dimerization tendency might play a regulatory role in T. brucei if the activation of tACs is similarly driven by ligand-induced dimerization as in membrane-bound guanylate cyclases." @default.
• W2087589470 created "2016-06-24" @default.
• W2087589470 creator A5033695434 @default.
• W2087589470 creator A5091071085 @default.
• W2087589470 date "2001-02-01" @default.
• W2087589470 modified "2023-10-16" @default.
• W2087589470 title "Structural analysis of adenylate cyclases from Trypanosoma brucei in their monomeric state" @default.
• W2087589470 cites W1034605816 @default.
• W2087589470 cites W1485109611 @default.
• W2087589470 cites W1536079196 @default.
• W2087589470 cites W1591680814 @default.
• W2087589470 cites W1602445963 @default.
• W2087589470 cites W1657879109 @default.
• W2087589470 cites W1800988456 @default.
• W2087589470 cites W1933463815 @default.
• W2087589470 cites W1968573434 @default.
• W2087589470 cites W1972038609 @default.
• W2087589470 cites W1972785606 @default.
• W2087589470 cites W1979131204 @default.
• W2087589470 cites W1980535904 @default.
• W2087589470 cites W1989789530 @default.
• W2087589470 cites W1991347361 @default.
• W2087589470 cites W1999120047 @default.
• W2087589470 cites W2000444382 @default.
• W2087589470 cites W2001641653 @default.
• W2087589470 cites W2005350874 @default.
• W2087589470 cites W2006726587 @default.
• W2087589470 cites W2015860873 @default.
• W2087589470 cites W2018874441 @default.
• W2087589470 cites W2020208163 @default.
• W2087589470 cites W2028344729 @default.
• W2087589470 cites W2029895712 @default.
• W2087589470 cites W2031379539 @default.
• W2087589470 cites W2031789967 @default.
• W2087589470 cites W2045198466 @default.
• W2087589470 cites W2060112173 @default.
• W2087589470 cites W2060913542 @default.
• W2087589470 cites W2070457843 @default.
• W2087589470 cites W2070815725 @default.
• W2087589470 cites W2077058243 @default.
• W2087589470 cites W2077744129 @default.
• W2087589470 cites W2078248419 @default.
• W2087589470 cites W2097382368 @default.
• W2087589470 cites W2099238754 @default.
• W2087589470 cites W2101446086 @default.
• W2087589470 cites W2117543614 @default.
• W2087589470 cites W2127824318 @default.
• W2087589470 cites W2144001627 @default.
• W2087589470 cites W2151421295 @default.
• W2087589470 cites W2156559790 @default.
• W2087589470 cites W2158714788 @default.
• W2087589470 cites W2161334687 @default.
• W2087589470 cites W2168958510 @default.
• W2087589470 cites W2336718390 @default.
• W2087589470 cites W2338433948 @default.
• W2087589470 cites W2397410656 @default.
• W2087589470 cites W4234528917 @default.
• W2087589470 doi "https://doi.org/10.1093/emboj/20.3.433" @default.
• W2087589470 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/133460" @default.
• W2087589470 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11157750" @default.
• W2087589470 hasPublicationYear "2001" @default.
• W2087589470 type Work @default.
• W2087589470 sameAs 2087589470 @default.
• W2087589470 citedByCount "58" @default.
• W2087589470 countsByYear W20875894702012 @default.
• W2087589470 countsByYear W20875894702013 @default.
• W2087589470 countsByYear W20875894702014 @default.
• W2087589470 countsByYear W20875894702015 @default.
• W2087589470 countsByYear W20875894702017 @default.
• W2087589470 countsByYear W20875894702018 @default.
• W2087589470 countsByYear W20875894702019 @default.
• W2087589470 countsByYear W20875894702022 @default.
• W2087589470 countsByYear W20875894702023 @default.
• W2087589470 crossrefType "journal-article" @default.
• W2087589470 hasAuthorship W2087589470A5033695434 @default.
• W2087589470 hasAuthorship W2087589470A5091071085 @default.
• W2087589470 hasBestOaLocation W20875894702 @default.
• W2087589470 hasConcept C104317684 @default.
• W2087589470 hasConcept C107824862 @default.
• W2087589470 hasConcept C12554922 @default.
• W2087589470 hasConcept C143065580 @default.
• W2087589470 hasConcept C16318435 @default.
• W2087589470 hasConcept C166342909 @default.
• W2087589470 hasConcept C180526460 @default.
• W2087589470 hasConcept C181199279 @default.
• W2087589470 hasConcept C185592680 @default.
• W2087589470 hasConcept C2779502636 @default.
• W2087589470 hasConcept C55493867 @default.
• W2087589470 hasConcept C71240020 @default.
• W2087589470 hasConcept C86803240 @default.
• W2087589470 hasConcept C95444343 @default.
• W2087589470 hasConceptScore W2087589470C104317684 @default.
• W2087589470 hasConceptScore W2087589470C107824862 @default.
• W2087589470 hasConceptScore W2087589470C12554922 @default.
• W2087589470 hasConceptScore W2087589470C143065580 @default.
• W2087589470 hasConceptScore W2087589470C16318435 @default.
• W2087589470 hasConceptScore W2087589470C166342909 @default.
• W2087589470 hasConceptScore W2087589470C180526460 @default.

• next