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- W2087598124 abstract "Although Parkinson disease (PD) is viewed traditionally as a motor syndrome secondary to nigrostriatal dopaminergic denervation, recent studies emphasize non-motor features. Non-motor comorbidities, such as cognitive impairment, are likely the result of an intricate interplay of multi-system degenerations and neurotransmitter deficiencies extending beyond the loss of dopaminergic nigral neurons. The pathological hallmark of parkinsonian dementia is the presence of extra-nigral Lewy bodies that can be accompanied by other pathologies, such as senile plaques. Lewy first identified the eponymous Lewy body in neurons of the nucleus basalis of Meynert (nbM), the source of cholinergic innervation of the cerebral cortex. Although cholinergic denervation is recognized as a pathological hallmark of Alzheimer disease (AD), in vivo neuroimaging studies reveal loss of cerebral cholinergic markers in parkinsonian dementia similar to or more severe than in prototypical AD. Imaging studies agree with post-mortem evidence suggesting that basal forebrain cholinergic system degeneration appears early in PD and worsens coincident with the appearance of dementia. Early cholinergic denervation in PD without dementia appears to be heterogeneous and may make specific contributions to the PD clinical phenotype. Apart from well-known cognitive and behavioral deficits, central, in particular limbic, cholinergic denervation may be associated with progressive deficits of odor identification in PD. Recent evidence indicates also that subcortical cholinergic denervation, probably due to degeneration of brainstem pedunculopontine nucleus neurons, may relate to the presence of dopamine non-responsive gait and balance impairments, including falls, in PD." @default.
- W2087598124 created "2016-06-24" @default.
- W2087598124 creator A5002817065 @default.
- W2087598124 creator A5014562669 @default.
- W2087598124 date "2011-08-01" @default.
- W2087598124 modified "2023-10-09" @default.
- W2087598124 title "The cholinergic system and Parkinson disease" @default.
- W2087598124 cites W1489935189 @default.
- W2087598124 cites W1519868135 @default.
- W2087598124 cites W1527753734 @default.
- W2087598124 cites W1795503014 @default.
- W2087598124 cites W1915201408 @default.
- W2087598124 cites W1964729801 @default.
- W2087598124 cites W1969480244 @default.
- W2087598124 cites W1971206380 @default.
- W2087598124 cites W1971579987 @default.
- W2087598124 cites W1972010893 @default.
- W2087598124 cites W1972153963 @default.
- W2087598124 cites W1973760481 @default.
- W2087598124 cites W1974426776 @default.
- W2087598124 cites W1974590920 @default.
- W2087598124 cites W1974878974 @default.
- W2087598124 cites W1982064952 @default.
- W2087598124 cites W1983103814 @default.
- W2087598124 cites W1983129817 @default.
- W2087598124 cites W1983356864 @default.
- W2087598124 cites W1983923023 @default.
- W2087598124 cites W1984001875 @default.
- W2087598124 cites W1984469633 @default.
- W2087598124 cites W1986152951 @default.
- W2087598124 cites W1986283880 @default.
- W2087598124 cites W1987003014 @default.
- W2087598124 cites W1988986349 @default.
- W2087598124 cites W1992386678 @default.
- W2087598124 cites W1996455718 @default.
- W2087598124 cites W1996794235 @default.
- W2087598124 cites W1997004893 @default.
- W2087598124 cites W1999191328 @default.
- W2087598124 cites W2001229741 @default.
- W2087598124 cites W2008222867 @default.
- W2087598124 cites W2009804051 @default.
- W2087598124 cites W2010120109 @default.
- W2087598124 cites W2013742256 @default.
- W2087598124 cites W2017453645 @default.
- W2087598124 cites W2018353688 @default.
- W2087598124 cites W2018998508 @default.
- W2087598124 cites W2019254928 @default.
- W2087598124 cites W2021139758 @default.
- W2087598124 cites W2022665453 @default.
- W2087598124 cites W2023796931 @default.
- W2087598124 cites W2026534317 @default.
- W2087598124 cites W2028064682 @default.
- W2087598124 cites W2028391864 @default.
- W2087598124 cites W2032687881 @default.
- W2087598124 cites W2033523068 @default.
- W2087598124 cites W2034046047 @default.
- W2087598124 cites W2034205060 @default.
- W2087598124 cites W2036999485 @default.
- W2087598124 cites W2037741322 @default.
- W2087598124 cites W2039194913 @default.
- W2087598124 cites W2039449904 @default.
- W2087598124 cites W2041295591 @default.
- W2087598124 cites W2042348810 @default.
- W2087598124 cites W2042431851 @default.
- W2087598124 cites W2044400428 @default.
- W2087598124 cites W2046324408 @default.
- W2087598124 cites W2047038935 @default.
- W2087598124 cites W2049100671 @default.
- W2087598124 cites W2049111961 @default.
- W2087598124 cites W2051573981 @default.
- W2087598124 cites W2053098177 @default.
- W2087598124 cites W2054135384 @default.
- W2087598124 cites W2058053122 @default.
- W2087598124 cites W2059272622 @default.
- W2087598124 cites W2059626992 @default.
- W2087598124 cites W2060196764 @default.
- W2087598124 cites W2061108135 @default.
- W2087598124 cites W2062964598 @default.
- W2087598124 cites W2063785968 @default.
- W2087598124 cites W2066191175 @default.
- W2087598124 cites W2066652406 @default.
- W2087598124 cites W2071196702 @default.
- W2087598124 cites W2073449985 @default.
- W2087598124 cites W2075843476 @default.
- W2087598124 cites W2079402537 @default.
- W2087598124 cites W2079462238 @default.
- W2087598124 cites W2079490962 @default.
- W2087598124 cites W2079727595 @default.
- W2087598124 cites W2080071110 @default.
- W2087598124 cites W2081857091 @default.
- W2087598124 cites W2083213758 @default.
- W2087598124 cites W2083403004 @default.
- W2087598124 cites W2085594747 @default.
- W2087598124 cites W2086218381 @default.
- W2087598124 cites W2086822708 @default.
- W2087598124 cites W2086968795 @default.
- W2087598124 cites W2087485448 @default.
- W2087598124 cites W2089486738 @default.