FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2087598635> ?p ?o ?g. }

• W2087598635 endingPage "505" @default.
• W2087598635 startingPage "490" @default.
• W2087598635 abstract "Abstract The failure of lesioned mammalian CNS neurons to regenerate their axons remains a challenge. Evidence is emerging that repulsive proteins contribute to this failure. The repulsive guidance molecule A (RGMA) induces growth cone collapse in vitro, accumulates in the scar after spinal cord injury, and is up‐regulated in glaucoma. In this study, we evaluated the spatial and temporal localization pattern of RGMA and its receptor neogenin in the optic nerve after optic nerve crush (ONC) without or with lens injury (LI) at up to nine time points (6 hr to 20 days) postsurgery by performing immunohistochemistry and Western blots. We found RGMA at the crush site (CS) and in the developing scar of ONC rats at every time point investigated, whereas it was absent in the CS of ONC + LI rats. Independent of the model, many cells were RGMA + in the ON: nerve fibers, blood vessels, astrocytes, oligodendrocytes, some microglia, some macrophages, and the sheath of the ON. Western blots showed a significantly lowered amount of RGMA in ONC + LI animals at 2, 4, and 6 days after crush compared with ONC animals. Furthermore, LI in sham‐operated animals showed an increase of RGMA in six of eight time points compared with the sham‐operated animals. Moreover, the effects of LI on the morphology of the ON were characterized at a level of detail never reported before. Our results show that RGMA is present and might contribute to the inhibitory environment in the ON, especially in and around the CS after ONC. © 2011 Wiley‐Liss, Inc." @default.
• W2087598635 created "2016-06-24" @default.
• W2087598635 creator A5003034830 @default.
• W2087598635 creator A5034392889 @default.
• W2087598635 creator A5052060292 @default.
• W2087598635 date "2011-02-02" @default.
• W2087598635 modified "2023-10-16" @default.
• W2087598635 title "Different spatial and temporal protein expressions of repulsive guidance molecule a and neogenin in the rat optic nerve after optic nerve crush with and without lens injury" @default.
• W2087598635 cites W1500809101 @default.
• W2087598635 cites W1675594938 @default.
• W2087598635 cites W1876601469 @default.
• W2087598635 cites W1881524532 @default.
• W2087598635 cites W1972893081 @default.
• W2087598635 cites W1983729552 @default.
• W2087598635 cites W1992203007 @default.
• W2087598635 cites W1994095808 @default.
• W2087598635 cites W1998309992 @default.
• W2087598635 cites W2001908895 @default.
• W2087598635 cites W2003600560 @default.
• W2087598635 cites W2006460975 @default.
• W2087598635 cites W2007011517 @default.
• W2087598635 cites W2008706165 @default.
• W2087598635 cites W2012058350 @default.
• W2087598635 cites W2016816247 @default.
• W2087598635 cites W2017476542 @default.
• W2087598635 cites W2018363432 @default.
• W2087598635 cites W2019211530 @default.
• W2087598635 cites W2019284274 @default.
• W2087598635 cites W2029152290 @default.
• W2087598635 cites W2030608964 @default.
• W2087598635 cites W2031711379 @default.
• W2087598635 cites W2034424045 @default.
• W2087598635 cites W2037303224 @default.
• W2087598635 cites W2039328257 @default.
• W2087598635 cites W2040463826 @default.
• W2087598635 cites W2041130246 @default.
• W2087598635 cites W2050833520 @default.
• W2087598635 cites W2053853398 @default.
• W2087598635 cites W2057932143 @default.
• W2087598635 cites W2059796270 @default.
• W2087598635 cites W2060372695 @default.
• W2087598635 cites W2081111010 @default.
• W2087598635 cites W2084891008 @default.
• W2087598635 cites W2085213635 @default.
• W2087598635 cites W2085386820 @default.
• W2087598635 cites W2089605039 @default.
• W2087598635 cites W2089786859 @default.
• W2087598635 cites W2091331379 @default.
• W2087598635 cites W2117250076 @default.
• W2087598635 cites W2118475834 @default.
• W2087598635 cites W2126548263 @default.
• W2087598635 cites W2133782231 @default.
• W2087598635 cites W2142267226 @default.
• W2087598635 cites W2142429722 @default.
• W2087598635 cites W2142697079 @default.
• W2087598635 cites W2147149841 @default.
• W2087598635 cites W2147701184 @default.
• W2087598635 cites W2150873412 @default.
• W2087598635 cites W2165038782 @default.
• W2087598635 cites W33441858 @default.
• W2087598635 cites W4231838548 @default.
• W2087598635 doi "https://doi.org/10.1002/jnr.22584" @default.
• W2087598635 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21290411" @default.
• W2087598635 hasPublicationYear "2011" @default.
• W2087598635 type Work @default.
• W2087598635 sameAs 2087598635 @default.
• W2087598635 citedByCount "18" @default.
• W2087598635 countsByYear W20875986352012 @default.
• W2087598635 countsByYear W20875986352013 @default.
• W2087598635 countsByYear W20875986352015 @default.
• W2087598635 countsByYear W20875986352017 @default.
• W2087598635 countsByYear W20875986352019 @default.
• W2087598635 countsByYear W20875986352021 @default.
• W2087598635 crossrefType "journal-article" @default.
• W2087598635 hasAuthorship W2087598635A5003034830 @default.
• W2087598635 hasAuthorship W2087598635A5034392889 @default.
• W2087598635 hasAuthorship W2087598635A5052060292 @default.
• W2087598635 hasConcept C104317684 @default.
• W2087598635 hasConcept C105702510 @default.
• W2087598635 hasConcept C126322002 @default.
• W2087598635 hasConcept C134018914 @default.
• W2087598635 hasConcept C169760540 @default.
• W2087598635 hasConcept C185592680 @default.
• W2087598635 hasConcept C204232928 @default.
• W2087598635 hasConcept C2775991916 @default.
• W2087598635 hasConcept C2780837183 @default.
• W2087598635 hasConcept C55493867 @default.
• W2087598635 hasConcept C71924100 @default.
• W2087598635 hasConcept C85265743 @default.
• W2087598635 hasConcept C86803240 @default.
• W2087598635 hasConcept C95444343 @default.
• W2087598635 hasConceptScore W2087598635C104317684 @default.
• W2087598635 hasConceptScore W2087598635C105702510 @default.
• W2087598635 hasConceptScore W2087598635C126322002 @default.
• W2087598635 hasConceptScore W2087598635C134018914 @default.
• W2087598635 hasConceptScore W2087598635C169760540 @default.
• W2087598635 hasConceptScore W2087598635C185592680 @default.
• W2087598635 hasConceptScore W2087598635C204232928 @default.

• next