Matches in SemOpenAlex for { <https://semopenalex.org/work/W2087599021> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2087599021 endingPage "15" @default.
- W2087599021 startingPage "3" @default.
- W2087599021 abstract "The effect of pyrazofurin, an inhibitor of UMP synthesis, on Plasmodium falciparum growth in vitro has been studied. ID50 values (concentration of compound causing 50% inhibition of [3H]hypoxanthine incorporation) for the FCQ-27, FCI-1 and K-1 (chloroquine-resistant) isolates were 10 ± 8.7, 6.4 ± 5.3 and 6.3 ± 0.5 μM, respectively. Comparative ID50 values for chloroquine were 13.5 ± 4.2, 22.8 ± 7.6 and 343 ± 114 nM, respectively. Over the 48-h intraerythrocytic cycle of tightly synchronized parasites, pyrazofurin both reduced the parasitemia and retarded the maturation of trophozoites and schizonts. Addition of uracil or uridine to the in vitro culture did not decrease the anti-parasitic activity of pyrazofurin. Chloroquine reduced the parasitemia, but did not retard development of the remaining viable parasites. Pyrazofurin (20 μM) caused a 50% inhibition of parasite orotate phosphoribosyltransferase (E.C. 2.4.2.10) and, in the presence of adenosine kinase and ATP, a 73% inhibition of orotidine-5′-phosphate decarboxylase (E.C. 4.1.1.23)." @default.
- W2087599021 created "2016-06-24" @default.
- W2087599021 creator A5008860734 @default.
- W2087599021 creator A5025350767 @default.
- W2087599021 creator A5055262595 @default.
- W2087599021 date "1986-01-01" @default.
- W2087599021 modified "2023-09-23" @default.
- W2087599021 title "In vitro inhibition of Plasmodium falciparum by pyrazofurin, an inhibitor of pyrimidine biosynthesis de novo" @default.
- W2087599021 cites W1557105861 @default.
- W2087599021 cites W1559599734 @default.
- W2087599021 cites W1876118699 @default.
- W2087599021 cites W1963740236 @default.
- W2087599021 cites W1969503178 @default.
- W2087599021 cites W1984164350 @default.
- W2087599021 cites W2009543343 @default.
- W2087599021 cites W2012789887 @default.
- W2087599021 cites W2018314479 @default.
- W2087599021 cites W2020251171 @default.
- W2087599021 cites W2020904878 @default.
- W2087599021 cites W2044018497 @default.
- W2087599021 cites W2063977318 @default.
- W2087599021 cites W2069841722 @default.
- W2087599021 cites W2075973224 @default.
- W2087599021 cites W2079599272 @default.
- W2087599021 cites W2088090805 @default.
- W2087599021 cites W2088332764 @default.
- W2087599021 cites W2105668259 @default.
- W2087599021 cites W2116439050 @default.
- W2087599021 cites W2127242166 @default.
- W2087599021 cites W2173108077 @default.
- W2087599021 cites W2319746560 @default.
- W2087599021 cites W2399449722 @default.
- W2087599021 cites W2414450500 @default.
- W2087599021 cites W2469904498 @default.
- W2087599021 cites W2969273703 @default.
- W2087599021 cites W3145894777 @default.
- W2087599021 cites W1605584133 @default.
- W2087599021 doi "https://doi.org/10.1016/0166-6851(86)90045-9" @default.
- W2087599021 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3515174" @default.
- W2087599021 hasPublicationYear "1986" @default.
- W2087599021 type Work @default.
- W2087599021 sameAs 2087599021 @default.
- W2087599021 citedByCount "42" @default.
- W2087599021 countsByYear W20875990212012 @default.
- W2087599021 countsByYear W20875990212013 @default.
- W2087599021 countsByYear W20875990212014 @default.
- W2087599021 countsByYear W20875990212015 @default.
- W2087599021 countsByYear W20875990212016 @default.
- W2087599021 countsByYear W20875990212018 @default.
- W2087599021 countsByYear W20875990212023 @default.
- W2087599021 crossrefType "journal-article" @default.
- W2087599021 hasAuthorship W2087599021A5008860734 @default.
- W2087599021 hasAuthorship W2087599021A5025350767 @default.
- W2087599021 hasAuthorship W2087599021A5055262595 @default.
- W2087599021 hasConcept C181199279 @default.
- W2087599021 hasConcept C202751555 @default.
- W2087599021 hasConcept C203014093 @default.
- W2087599021 hasConcept C2775867548 @default.
- W2087599021 hasConcept C2777425658 @default.
- W2087599021 hasConcept C2778048844 @default.
- W2087599021 hasConcept C2778371730 @default.
- W2087599021 hasConcept C2781116151 @default.
- W2087599021 hasConcept C55493867 @default.
- W2087599021 hasConcept C86803240 @default.
- W2087599021 hasConceptScore W2087599021C181199279 @default.
- W2087599021 hasConceptScore W2087599021C202751555 @default.
- W2087599021 hasConceptScore W2087599021C203014093 @default.
- W2087599021 hasConceptScore W2087599021C2775867548 @default.
- W2087599021 hasConceptScore W2087599021C2777425658 @default.
- W2087599021 hasConceptScore W2087599021C2778048844 @default.
- W2087599021 hasConceptScore W2087599021C2778371730 @default.
- W2087599021 hasConceptScore W2087599021C2781116151 @default.
- W2087599021 hasConceptScore W2087599021C55493867 @default.
- W2087599021 hasConceptScore W2087599021C86803240 @default.
- W2087599021 hasIssue "1" @default.
- W2087599021 hasLocation W20875990211 @default.
- W2087599021 hasLocation W20875990212 @default.
- W2087599021 hasOpenAccess W2087599021 @default.
- W2087599021 hasPrimaryLocation W20875990211 @default.
- W2087599021 hasRelatedWork W1564134470 @default.
- W2087599021 hasRelatedWork W194330704 @default.
- W2087599021 hasRelatedWork W1998795420 @default.
- W2087599021 hasRelatedWork W2008137254 @default.
- W2087599021 hasRelatedWork W2031620658 @default.
- W2087599021 hasRelatedWork W2061715178 @default.
- W2087599021 hasRelatedWork W2065940471 @default.
- W2087599021 hasRelatedWork W2227072991 @default.
- W2087599021 hasRelatedWork W31603331 @default.
- W2087599021 hasRelatedWork W893743419 @default.
- W2087599021 hasVolume "18" @default.
- W2087599021 isParatext "false" @default.
- W2087599021 isRetracted "false" @default.
- W2087599021 magId "2087599021" @default.
- W2087599021 workType "article" @default.