Matches in SemOpenAlex for { <https://semopenalex.org/work/W2087602743> ?p ?o ?g. }
- W2087602743 endingPage "447" @default.
- W2087602743 startingPage "440" @default.
- W2087602743 abstract "Purpose of review Infectious agents are still thought to be involved in the origin of inflammatory bowel disease. The focus in recent years has been more on Mycobacterium avium subsp paratuberculosis, adherent-invasive Escherichia coli or yeasts. Recent findings A metaanalysis has shown a significant association of M. avium subsp paratuberculosis and Crohn's disease and a large randomized placebo-controlled trial reported an absence of sustained beneficial effects of combined antibiotic therapy on remission of active Crohn's disease. Adherent-invasive E. coli adhere via type 1 pili to carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6), abnormally expressed by intestinal epithelial cells in Crohn's disease patients. Both colonization of the ileal mucosa and stimulation of ileal epithelial cells by tumour necrosis factor-α induce overexpression of CEACAM6, leading to an amplification loop of colonization and inflammation. Anti-Saccharomyces cerevisiae mannan antibodies are the most prevalent serologic marker in Crohn's disease. Major oligomannose epitopes supporting antibody formation are expressed by Candida albicans in human tissues, suggesting that a loss of tolerance to C. albicans could lead to antibody formation in a subset of Crohn's disease patients who are genetically predisposed. Summary M. avium subsp paratuberculosis, adherent-invasive E. coli and Candida are good candidates for an infectious aetiology of Crohn's disease on the basis of genetic susceptibility, which relates to impaired function in the defence against intracellular bacteria." @default.
- W2087602743 created "2016-06-24" @default.
- W2087602743 creator A5008009093 @default.
- W2087602743 creator A5015470174 @default.
- W2087602743 creator A5044363342 @default.
- W2087602743 creator A5067398092 @default.
- W2087602743 date "2008-07-01" @default.
- W2087602743 modified "2023-10-18" @default.
- W2087602743 title "Pathogenic agents in inflammatory bowel diseases" @default.
- W2087602743 cites W1508342222 @default.
- W2087602743 cites W1519633296 @default.
- W2087602743 cites W1606391882 @default.
- W2087602743 cites W1642457845 @default.
- W2087602743 cites W1670573097 @default.
- W2087602743 cites W1966597734 @default.
- W2087602743 cites W1967334538 @default.
- W2087602743 cites W1979423810 @default.
- W2087602743 cites W1979771705 @default.
- W2087602743 cites W1979859398 @default.
- W2087602743 cites W1988338328 @default.
- W2087602743 cites W1991081070 @default.
- W2087602743 cites W1997146138 @default.
- W2087602743 cites W2009706335 @default.
- W2087602743 cites W2010244810 @default.
- W2087602743 cites W2012382096 @default.
- W2087602743 cites W2014571027 @default.
- W2087602743 cites W2018544780 @default.
- W2087602743 cites W2029029955 @default.
- W2087602743 cites W2029575231 @default.
- W2087602743 cites W2030116497 @default.
- W2087602743 cites W2030421888 @default.
- W2087602743 cites W2036677443 @default.
- W2087602743 cites W2038343076 @default.
- W2087602743 cites W2038835308 @default.
- W2087602743 cites W2039954708 @default.
- W2087602743 cites W2042260827 @default.
- W2087602743 cites W2043667001 @default.
- W2087602743 cites W2048058913 @default.
- W2087602743 cites W2050774934 @default.
- W2087602743 cites W2052360954 @default.
- W2087602743 cites W2057610674 @default.
- W2087602743 cites W2059094017 @default.
- W2087602743 cites W2062879226 @default.
- W2087602743 cites W2063887836 @default.
- W2087602743 cites W2067127765 @default.
- W2087602743 cites W2072896519 @default.
- W2087602743 cites W2074418648 @default.
- W2087602743 cites W2075542920 @default.
- W2087602743 cites W2078621117 @default.
- W2087602743 cites W2078737633 @default.
- W2087602743 cites W2079338443 @default.
- W2087602743 cites W2085579911 @default.
- W2087602743 cites W2100265489 @default.
- W2087602743 cites W2103760724 @default.
- W2087602743 cites W2104061045 @default.
- W2087602743 cites W2107285671 @default.
- W2087602743 cites W2107965805 @default.
- W2087602743 cites W2110248012 @default.
- W2087602743 cites W2111919009 @default.
- W2087602743 cites W2112449462 @default.
- W2087602743 cites W2115207445 @default.
- W2087602743 cites W2122031852 @default.
- W2087602743 cites W2126529413 @default.
- W2087602743 cites W2128474861 @default.
- W2087602743 cites W2129432414 @default.
- W2087602743 cites W2129487696 @default.
- W2087602743 cites W2144631023 @default.
- W2087602743 cites W2145313425 @default.
- W2087602743 cites W2147604667 @default.
- W2087602743 cites W2148455779 @default.
- W2087602743 cites W2151088711 @default.
- W2087602743 cites W2152822836 @default.
- W2087602743 cites W2153719950 @default.
- W2087602743 cites W2153905079 @default.
- W2087602743 cites W2156698513 @default.
- W2087602743 cites W2158820172 @default.
- W2087602743 cites W2162130987 @default.
- W2087602743 cites W2163120329 @default.
- W2087602743 cites W2165279431 @default.
- W2087602743 cites W2165407078 @default.
- W2087602743 cites W2167840222 @default.
- W2087602743 cites W2169909966 @default.
- W2087602743 cites W2170928068 @default.
- W2087602743 cites W2171967025 @default.
- W2087602743 cites W2333579983 @default.
- W2087602743 cites W4292198229 @default.
- W2087602743 doi "https://doi.org/10.1097/mog.0b013e3283023be5" @default.
- W2087602743 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18622157" @default.
- W2087602743 hasPublicationYear "2008" @default.
- W2087602743 type Work @default.
- W2087602743 sameAs 2087602743 @default.
- W2087602743 citedByCount "49" @default.
- W2087602743 countsByYear W20876027432012 @default.
- W2087602743 countsByYear W20876027432013 @default.
- W2087602743 countsByYear W20876027432014 @default.
- W2087602743 countsByYear W20876027432015 @default.
- W2087602743 countsByYear W20876027432016 @default.
- W2087602743 countsByYear W20876027432017 @default.