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• W2087604494 abstract "A series of 18 differently substituted new aryl hetaryl ketones and thioketones were synthesized in four to six steps from commercial starting materials. The new ketones were evaluated as inhibitors of the peptidyl-prolyl cis-trans isomerase hPin1 with K(i) values ranging in the one-digit micromolar to sub-micromolar numbers. A crystal structure revealed the non-planar arrangement of the aryl residues at the carbonyl compound and supports the hypothesis that the new compounds might mimic the transition state of the enzymatic conversion." @default.
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• W2087604494 date "2012-11-01" @default.
• W2087604494 modified "2023-09-30" @default.
• W2087604494 title "Aryl Hetaryl Ketones and Thioketones as Efficient Inhibitors of Peptidyl-Prolyl<i>cis</i>-<i>trans</i>Isomerases" @default.
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• W2087604494 doi "https://doi.org/10.1002/cbdv.201200275" @default.
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