FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2087613020> ?p ?o ?g. }

• W2087613020 endingPage "814" @default.
• W2087613020 startingPage "807" @default.
• W2087613020 abstract "Although in experimental hypertension the cardioprotective effects of ischemic preconditioning (PC) appear to be maintained, most studies have examined the short-term hypertension in juvenile animals. However, aging may be an additional factor that influences the effectiveness of PC. The aim of this study was to characterise the effects on PC of LVH and aging simultaneously. Hearts from spontaneously hypertensive rats (SHR) and age-matched normotensive Wistar-Kyoto rats (WKY) were studied. Excised hearts were Langendorff-perfused to give equivalent coronary flow per gram heart weight. The left main coronary artery was occluded for 35 min followed by 120 min reperfusion. Infarct size was determined by tetrazolium staining. Heart size was assessed as left ventricle/body weight ratio (LV/BW). PC was effected with 2 x 5 min periods of global ischemia prior to coronary occlusion. Hearts were studied at 3-4 months (juvenile), 7-8 months (mature) or 12-13 months (aging). LV/BW ratio in SHR increased relative to WKY controls by 20%, 32% and 40% in juvenile, mature and aging hearts, respectively, but ischemic risk zone size was similar in all groups (52-59% of LV). PC was equally effective at limiting infarct size in juvenile and mature SHR and WKY hearts but was ineffective in aging hearts from both WKY and SHR. Since angiotensin-converting enzyme inhibitors enhance sub-threshold PC in normal myocardium, we also examined the action of captopril (Cap) in aging hearts. Additional aging hearts received treatment with Cap 200 microM as an adjunct to PC. Although Cap+PC was able to induce modest protection in aging WKY hearts, this was not seen in aging SHR hearts. We conclude that PC is lost in longstanding hypertension through independent contributions of both hypertension and aging. These findings may have implications for the clinical development of preconditioning-based therapies since elderly patients with longstanding hypertension are at high risk of developing ischemic heart disease." @default.
• W2087613020 created "2016-06-24" @default.
• W2087613020 creator A5036662362 @default.
• W2087613020 creator A5061239268 @default.
• W2087613020 creator A5090808868 @default.
• W2087613020 date "2007-08-01" @default.
• W2087613020 modified "2023-09-26" @default.
• W2087613020 title "Ischemic preconditioning is lost in aging hypertensive rat heart: Independent effects of aging and longstanding hypertension" @default.
• W2087613020 cites W1925029346 @default.
• W2087613020 cites W1965036621 @default.
• W2087613020 cites W1974554242 @default.
• W2087613020 cites W1986729897 @default.
• W2087613020 cites W1988410058 @default.
• W2087613020 cites W2015887765 @default.
• W2087613020 cites W2019347721 @default.
• W2087613020 cites W2026638989 @default.
• W2087613020 cites W2028205521 @default.
• W2087613020 cites W2030810335 @default.
• W2087613020 cites W2037200837 @default.
• W2087613020 cites W2040184775 @default.
• W2087613020 cites W2047430554 @default.
• W2087613020 cites W2047854671 @default.
• W2087613020 cites W2047876380 @default.
• W2087613020 cites W2065087791 @default.
• W2087613020 cites W2065376987 @default.
• W2087613020 cites W2066119862 @default.
• W2087613020 cites W2075088199 @default.
• W2087613020 cites W2075857100 @default.
• W2087613020 cites W2081993192 @default.
• W2087613020 cites W2112632966 @default.
• W2087613020 cites W2133509496 @default.
• W2087613020 cites W2135406819 @default.
• W2087613020 cites W2140144738 @default.
• W2087613020 cites W2144782341 @default.
• W2087613020 cites W2146217294 @default.
• W2087613020 cites W2150214260 @default.
• W2087613020 cites W2151903019 @default.
• W2087613020 cites W2159804480 @default.
• W2087613020 cites W2164345589 @default.
• W2087613020 cites W2169806115 @default.
• W2087613020 cites W2188819414 @default.
• W2087613020 cites W2336490398 @default.
• W2087613020 cites W2420416094 @default.
• W2087613020 doi "https://doi.org/10.1016/j.exger.2007.04.005" @default.
• W2087613020 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17532161" @default.
• W2087613020 hasPublicationYear "2007" @default.
• W2087613020 type Work @default.
• W2087613020 sameAs 2087613020 @default.
• W2087613020 citedByCount "79" @default.
• W2087613020 countsByYear W20876130202012 @default.
• W2087613020 countsByYear W20876130202013 @default.
• W2087613020 countsByYear W20876130202014 @default.
• W2087613020 countsByYear W20876130202015 @default.
• W2087613020 countsByYear W20876130202016 @default.
• W2087613020 countsByYear W20876130202017 @default.
• W2087613020 countsByYear W20876130202018 @default.
• W2087613020 countsByYear W20876130202019 @default.
• W2087613020 countsByYear W20876130202020 @default.
• W2087613020 countsByYear W20876130202021 @default.
• W2087613020 countsByYear W20876130202022 @default.
• W2087613020 countsByYear W20876130202023 @default.
• W2087613020 crossrefType "journal-article" @default.
• W2087613020 hasAuthorship W2087613020A5036662362 @default.
• W2087613020 hasAuthorship W2087613020A5061239268 @default.
• W2087613020 hasAuthorship W2087613020A5090808868 @default.
• W2087613020 hasBestOaLocation W20876130201 @default.
• W2087613020 hasConcept C126322002 @default.
• W2087613020 hasConcept C134018914 @default.
• W2087613020 hasConcept C164705383 @default.
• W2087613020 hasConcept C2778921608 @default.
• W2087613020 hasConcept C2779479957 @default.
• W2087613020 hasConcept C2780393670 @default.
• W2087613020 hasConcept C541997718 @default.
• W2087613020 hasConcept C71924100 @default.
• W2087613020 hasConcept C84393581 @default.
• W2087613020 hasConceptScore W2087613020C126322002 @default.
• W2087613020 hasConceptScore W2087613020C134018914 @default.
• W2087613020 hasConceptScore W2087613020C164705383 @default.
• W2087613020 hasConceptScore W2087613020C2778921608 @default.
• W2087613020 hasConceptScore W2087613020C2779479957 @default.
• W2087613020 hasConceptScore W2087613020C2780393670 @default.
• W2087613020 hasConceptScore W2087613020C541997718 @default.
• W2087613020 hasConceptScore W2087613020C71924100 @default.
• W2087613020 hasConceptScore W2087613020C84393581 @default.
• W2087613020 hasIssue "8" @default.
• W2087613020 hasLocation W20876130201 @default.
• W2087613020 hasLocation W20876130202 @default.
• W2087613020 hasOpenAccess W2087613020 @default.
• W2087613020 hasPrimaryLocation W20876130201 @default.
• W2087613020 hasRelatedWork W10601204 @default.
• W2087613020 hasRelatedWork W1966504330 @default.
• W2087613020 hasRelatedWork W1979139803 @default.
• W2087613020 hasRelatedWork W2004601441 @default.
• W2087613020 hasRelatedWork W2016382497 @default.
• W2087613020 hasRelatedWork W2037631372 @default.
• W2087613020 hasRelatedWork W2102363854 @default.
• W2087613020 hasRelatedWork W2168732577 @default.
• W2087613020 hasRelatedWork W2427221735 @default.

• next