Matches in SemOpenAlex for { <https://semopenalex.org/work/W2087616097> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2087616097 endingPage "39" @default.
- W2087616097 startingPage "31" @default.
- W2087616097 abstract "Isolated bovine retinas possess the ability to concentrate tryptamine from an external medium. The entry mechanism is independent of sodium and other cations, but is dependent on temperature. Kinetic analysis of the tryptamine uptake shows a single mechanism with Km and Vmax values of 2 × 10−5m and 50 pmol/mg/min respectively. A lack of specificity in the process is indicated by its insensitivity to a number of metabolic inhibitors and various analogues. Autoradiography has shown that specific neuronal processes, associated with the inner plexiform layer, take up serotonin (5-hydroxytryptamine) and that this accumulation can be inhibited by p-chlorophenylalanine. Tryptamine is not taken up by any specific components. It is also demonstrated that synaptosomes derived from the inner plexiform layer take up more serotonin than tryptamine. Furthermore, radioactivity is rapidly released from tissue loaded with [3H]tryptamine, and this process cannot be stimulated by potassium chloride. This contrasts with tissue loaded with [3H]serotonin, where the spontaneous release of the substance is not so rapid but can nevertheless be stimulated by potassium chloride treatment. It is concluded that the total uptake of tryptamine resembles the low affinity unspecific uptake mechanism for serotonin. The specificity of the high affinity uptake mechanism for serotonin, together with the autoradiographical and release experiments, can be taken to support the idea that serotonin is a transmitter in the retina. On the other hand, there is no evidence of tryptamine being a likely transmitter in the retina." @default.
- W2087616097 created "2016-06-24" @default.
- W2087616097 creator A5001481005 @default.
- W2087616097 creator A5069352403 @default.
- W2087616097 date "1980-07-01" @default.
- W2087616097 modified "2023-09-27" @default.
- W2087616097 title "Specificity of serotonin uptake by bovine retina: Comparison with tryptamine" @default.
- W2087616097 cites W1775749144 @default.
- W2087616097 cites W1968901885 @default.
- W2087616097 cites W1977320631 @default.
- W2087616097 cites W1989986017 @default.
- W2087616097 cites W1992879480 @default.
- W2087616097 cites W1999610376 @default.
- W2087616097 cites W2030346856 @default.
- W2087616097 cites W2043375937 @default.
- W2087616097 cites W2060271831 @default.
- W2087616097 cites W2066277308 @default.
- W2087616097 cites W2066965650 @default.
- W2087616097 cites W2067753855 @default.
- W2087616097 cites W2075896686 @default.
- W2087616097 doi "https://doi.org/10.1016/0014-4835(80)90088-3" @default.
- W2087616097 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7428837" @default.
- W2087616097 hasPublicationYear "1980" @default.
- W2087616097 type Work @default.
- W2087616097 sameAs 2087616097 @default.
- W2087616097 citedByCount "24" @default.
- W2087616097 countsByYear W20876160972023 @default.
- W2087616097 crossrefType "journal-article" @default.
- W2087616097 hasAuthorship W2087616097A5001481005 @default.
- W2087616097 hasAuthorship W2087616097A5069352403 @default.
- W2087616097 hasConcept C12554922 @default.
- W2087616097 hasConcept C169760540 @default.
- W2087616097 hasConcept C170493617 @default.
- W2087616097 hasConcept C178790620 @default.
- W2087616097 hasConcept C185592680 @default.
- W2087616097 hasConcept C2775864247 @default.
- W2087616097 hasConcept C2777093970 @default.
- W2087616097 hasConcept C2777135210 @default.
- W2087616097 hasConcept C2780827179 @default.
- W2087616097 hasConcept C2781099447 @default.
- W2087616097 hasConcept C517785266 @default.
- W2087616097 hasConcept C537181965 @default.
- W2087616097 hasConcept C53910766 @default.
- W2087616097 hasConcept C55493867 @default.
- W2087616097 hasConcept C86803240 @default.
- W2087616097 hasConceptScore W2087616097C12554922 @default.
- W2087616097 hasConceptScore W2087616097C169760540 @default.
- W2087616097 hasConceptScore W2087616097C170493617 @default.
- W2087616097 hasConceptScore W2087616097C178790620 @default.
- W2087616097 hasConceptScore W2087616097C185592680 @default.
- W2087616097 hasConceptScore W2087616097C2775864247 @default.
- W2087616097 hasConceptScore W2087616097C2777093970 @default.
- W2087616097 hasConceptScore W2087616097C2777135210 @default.
- W2087616097 hasConceptScore W2087616097C2780827179 @default.
- W2087616097 hasConceptScore W2087616097C2781099447 @default.
- W2087616097 hasConceptScore W2087616097C517785266 @default.
- W2087616097 hasConceptScore W2087616097C537181965 @default.
- W2087616097 hasConceptScore W2087616097C53910766 @default.
- W2087616097 hasConceptScore W2087616097C55493867 @default.
- W2087616097 hasConceptScore W2087616097C86803240 @default.
- W2087616097 hasIssue "1" @default.
- W2087616097 hasLocation W20876160971 @default.
- W2087616097 hasLocation W20876160972 @default.
- W2087616097 hasOpenAccess W2087616097 @default.
- W2087616097 hasPrimaryLocation W20876160971 @default.
- W2087616097 hasRelatedWork W147632 @default.
- W2087616097 hasRelatedWork W2005219662 @default.
- W2087616097 hasRelatedWork W2009971493 @default.
- W2087616097 hasRelatedWork W2069671370 @default.
- W2087616097 hasRelatedWork W2087616097 @default.
- W2087616097 hasRelatedWork W2135112754 @default.
- W2087616097 hasRelatedWork W236653838 @default.
- W2087616097 hasRelatedWork W2427175759 @default.
- W2087616097 hasRelatedWork W328618257 @default.
- W2087616097 hasRelatedWork W3100634260 @default.
- W2087616097 hasVolume "31" @default.
- W2087616097 isParatext "false" @default.
- W2087616097 isRetracted "false" @default.
- W2087616097 magId "2087616097" @default.
- W2087616097 workType "article" @default.