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- W2087620462 abstract "Abstract Acidic amino acids were tested by histological criteria for their ability to destroy rat hippocampal neurons. When injected directly into the hippocampal formation, kainic acid preferentially destroyed CA3-CA4 pyramidal cells and was least toxic toward dentate granule cells and pyramidal cells of the h2 area. All other acidic amino acids tested destroyed hippocampal neurons non-selectively, the vulnerability of these neurons depending simply on their proximity to the injection site. At sufficient doses, kainic acid destroyed neurons in distant limbic regions, but the other acidic amino acids did not. All amino acid excitants tested were neurotoxic, the order of potency being:kainate>ibotenate>N-methyl- dl -aspartate>dihydrokainate> dl -homocysteate> l -cysteate> l -aspartate> l -glutamate. Most excitatory amino acid antagonists were only very weakly neurotoxic, but the phosphonate analogues of glutamate and aspartate were about as potent as the strong excitants, dl -homocysteate and l -cysteate. Intraventricular injections similarly revealed a distinction between selective hippocampal lesions made by kainic acid and non-selective hippocampal lesions made by high doses of other acidic amino acids. These results generally support previous correlations between neuro-excitatory and neurotoxic effects of acidic amino acids. However, the considerable neurotoxic potency of the phosphonate antagonists is difficult to reconcile with the conventional view that the ability of acidic amino acids to destroy neurons is determined solely by their ability to depolarize them. Several mechanisms are discussed to account for the different patterns of neuronal cell death observed after injection of kainic acid and other acidic amino acids. Finally,N-methyl- dl -aspartate is suggested as a useful agent for making localized axonsparing lesions." @default.
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- W2087620462 title "Comparative toxicity of kainic acid and other acidic amino acids toward rat hippocampal neurons" @default.
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- W2087620462 doi "https://doi.org/10.1016/0306-4522(81)90096-8" @default.
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