FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2087622504> ?p ?o ?g. }

• W2087622504 abstract "Ganglioside AGF2 attenuated both the cognitive impairments and the cholinergic hypofunction induced by ethylcholine aziridinium ion (AF64A). Adult male rats were initially trained to perform a standard radial arm maze (RAM) task. Following training, they were injected intraperitoneally with 10 mg/kg AGF2 (AF/AGF2, CSF/AGF2) or the saline vehicle (AF/SAL, CSF/SAL) for 3 days prior to and for 14 days following bilateral injection of AF64A (3 nmol/side) or artificial CSF into the lateral ventricles. AF64A (AF/SAL) impaired performance of the standard RAM task and a working memory version of the task in which various delays were imposed between the fourth and fifth arm choices. In contrast, animals that received AGF2 and AF64A (AF/AGF2) were initially impaired on the standard RAM task but rapidly recovered and were performing as well as the control groups (CSF/SAL, CSF/AGF2) by the end of training. The AF/AGF2 group, however, exhibited persistent deficits on the working memory version of the RAM task. These data demonstrate that AGF2 promotes behavioral recovery in a task-dependent manner in this model system. Neurochemical analysis revealed that AF64A produced a significant 37% decrease in hippocampal ChAT activity that was significantly attenuated, but not prevented, by prior treatment with AGF2. Thus the behavioral recovery afforded by AGF2 might be related to increased cholinergic activity in the hippocampus that is sufficient for the performance of tasks which either lack or have a minimal working memory component. An analysis of the temporal profile of AGF2-induced neurochemical recovery revealed that ChAT activity was enhanced at 20, but not 2 or 11, weeks following AF64A. Since AGF2 did not attenuate the cholinergic cell loss (35%) induced by AF64A in the medial septum these data indicate that AGF2 might have (1) enhanced sprouting of cholinergic terminals following the initial insult, (2) directly increased ChAT activity in surviving neurons, or (3) induced behavioral and neurochemical recovery through a combination of these or other mechanisms." @default.
• W2087622504 created "2016-06-24" @default.
• W2087622504 creator A5058329121 @default.
• W2087622504 creator A5071800632 @default.
• W2087622504 date "1990-09-01" @default.
• W2087622504 modified "2023-10-14" @default.
• W2087622504 title "Ganglioside AGF2 promotes task-specific recovery and attenuates the cholinergic hypofunction induced by AF64A" @default.
• W2087622504 cites W1483896720 @default.
• W2087622504 cites W1526596922 @default.
• W2087622504 cites W1546475894 @default.
• W2087622504 cites W1853026346 @default.
• W2087622504 cites W1864895155 @default.
• W2087622504 cites W1967595151 @default.
• W2087622504 cites W1972266939 @default.
• W2087622504 cites W1974280173 @default.
• W2087622504 cites W1977092688 @default.
• W2087622504 cites W1981939261 @default.
• W2087622504 cites W1984332083 @default.
• W2087622504 cites W1984727997 @default.
• W2087622504 cites W1986010621 @default.
• W2087622504 cites W1989314580 @default.
• W2087622504 cites W1989981999 @default.
• W2087622504 cites W1993309635 @default.
• W2087622504 cites W1994067502 @default.
• W2087622504 cites W1997531101 @default.
• W2087622504 cites W2000277057 @default.
• W2087622504 cites W2004563948 @default.
• W2087622504 cites W2005422992 @default.
• W2087622504 cites W2015600557 @default.
• W2087622504 cites W2016290185 @default.
• W2087622504 cites W2017957851 @default.
• W2087622504 cites W2020751425 @default.
• W2087622504 cites W2025226461 @default.
• W2087622504 cites W2028393896 @default.
• W2087622504 cites W2028404719 @default.
• W2087622504 cites W2030176564 @default.
• W2087622504 cites W2030365597 @default.
• W2087622504 cites W2036697086 @default.
• W2087622504 cites W2037312161 @default.
• W2087622504 cites W2038092781 @default.
• W2087622504 cites W2038524677 @default.
• W2087622504 cites W2050030644 @default.
• W2087622504 cites W2068959349 @default.
• W2087622504 cites W2073383817 @default.
• W2087622504 cites W2081001645 @default.
• W2087622504 cites W2084478217 @default.
• W2087622504 cites W2084728059 @default.
• W2087622504 cites W2085533627 @default.
• W2087622504 cites W2091958137 @default.
• W2087622504 cites W2117640165 @default.
• W2087622504 cites W2119125561 @default.
• W2087622504 cites W2128635872 @default.
• W2087622504 cites W2130495692 @default.
• W2087622504 cites W2142276934 @default.
• W2087622504 cites W2181837042 @default.
• W2087622504 doi "https://doi.org/10.1016/0006-8993(90)91150-f" @default.
• W2087622504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2253037" @default.
• W2087622504 hasPublicationYear "1990" @default.
• W2087622504 type Work @default.
• W2087622504 sameAs 2087622504 @default.
• W2087622504 citedByCount "27" @default.
• W2087622504 countsByYear W20876225042015 @default.
• W2087622504 countsByYear W20876225042017 @default.
• W2087622504 crossrefType "journal-article" @default.
• W2087622504 hasAuthorship W2087622504A5058329121 @default.
• W2087622504 hasAuthorship W2087622504A5071800632 @default.
• W2087622504 hasConcept C126322002 @default.
• W2087622504 hasConcept C13260007 @default.
• W2087622504 hasConcept C134018914 @default.
• W2087622504 hasConcept C148762608 @default.
• W2087622504 hasConcept C15744967 @default.
• W2087622504 hasConcept C169760540 @default.
• W2087622504 hasConcept C169900460 @default.
• W2087622504 hasConcept C21963081 @default.
• W2087622504 hasConcept C22885893 @default.
• W2087622504 hasConcept C25876315 @default.
• W2087622504 hasConcept C2781161787 @default.
• W2087622504 hasConcept C71924100 @default.
• W2087622504 hasConceptScore W2087622504C126322002 @default.
• W2087622504 hasConceptScore W2087622504C13260007 @default.
• W2087622504 hasConceptScore W2087622504C134018914 @default.
• W2087622504 hasConceptScore W2087622504C148762608 @default.
• W2087622504 hasConceptScore W2087622504C15744967 @default.
• W2087622504 hasConceptScore W2087622504C169760540 @default.
• W2087622504 hasConceptScore W2087622504C169900460 @default.
• W2087622504 hasConceptScore W2087622504C21963081 @default.
• W2087622504 hasConceptScore W2087622504C22885893 @default.
• W2087622504 hasConceptScore W2087622504C25876315 @default.
• W2087622504 hasConceptScore W2087622504C2781161787 @default.
• W2087622504 hasConceptScore W2087622504C71924100 @default.
• W2087622504 hasLocation W20876225041 @default.
• W2087622504 hasLocation W20876225042 @default.
• W2087622504 hasOpenAccess W2087622504 @default.
• W2087622504 hasPrimaryLocation W20876225041 @default.
• W2087622504 hasRelatedWork W1968521183 @default.
• W2087622504 hasRelatedWork W1985759952 @default.
• W2087622504 hasRelatedWork W2035338166 @default.
• W2087622504 hasRelatedWork W2046155244 @default.
• W2087622504 hasRelatedWork W2060198709 @default.
• W2087622504 hasRelatedWork W2069958148 @default.

• next