Matches in SemOpenAlex for { <https://semopenalex.org/work/W2087623617> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2087623617 endingPage "1221" @default.
- W2087623617 startingPage "1215" @default.
- W2087623617 abstract "Twenty-nine immunocompromised patients were treated with intravenous trimethoprim-sulfamethoxazole for possible Pneumocystis carinii pneumonia. The diagnosis was established in 15 severely hypoxemic patients with lymphoreticular malignancy or cardiac transplants by open lung biopsy or transthoracic needle aspirate. In 13 (87 percent) of the 15, the response to therapy was rapid. They became afebrile in a mean of 2.1 days, showed improved arterial blood oxygenation in 4.7 days and improvement on the chest roentgenogram in 4.3 days. Eight (53 percent) of the 15 survived and were clinically cured. Five other patients with documented P. carinii infection improved clinically but subsequently died of other causes. Postmortem examination in these showed no P. carinii cysts. Two patients with P. carinii pneumonia died soon after therapy was started and had P. carinii cysts in lung tissue at autopsy. The combined clinical and microbiologic response of 87 percent equals or exceeds that of other reported treatment regimens. Intravenous trimethoprim-sulfamethoxazole may, therefore, be the most ideal therapy for severely ill adults with P. carinii pneumonia. Second lung biopsies in 12 patients on therapy showed that P. carinii cysts were rarely found after several days of treatment. This suggests that lung tissue may be falsely negative for P. carinii cysts in persons treated empirically but who later undergo lung biopsy." @default.
- W2087623617 created "2016-06-24" @default.
- W2087623617 creator A5012534523 @default.
- W2087623617 creator A5058875385 @default.
- W2087623617 date "1981-06-01" @default.
- W2087623617 modified "2023-09-26" @default.
- W2087623617 title "Intravenous trimethoprim-sulfamethoxazole therapy for pneumocystis carinii pneumonia" @default.
- W2087623617 cites W1566027956 @default.
- W2087623617 cites W1982455508 @default.
- W2087623617 cites W1985064213 @default.
- W2087623617 cites W1987157628 @default.
- W2087623617 cites W1997316746 @default.
- W2087623617 cites W2011525824 @default.
- W2087623617 cites W2023854740 @default.
- W2087623617 cites W2030679843 @default.
- W2087623617 cites W2033446763 @default.
- W2087623617 cites W2046591225 @default.
- W2087623617 cites W2052578217 @default.
- W2087623617 cites W2052810026 @default.
- W2087623617 cites W2080479114 @default.
- W2087623617 cites W2081284781 @default.
- W2087623617 cites W2122049462 @default.
- W2087623617 cites W2135697160 @default.
- W2087623617 cites W2151619842 @default.
- W2087623617 cites W2304100187 @default.
- W2087623617 cites W2320124079 @default.
- W2087623617 cites W2320377369 @default.
- W2087623617 cites W2332355941 @default.
- W2087623617 cites W2338138381 @default.
- W2087623617 cites W2407693539 @default.
- W2087623617 cites W2766870461 @default.
- W2087623617 cites W3024876814 @default.
- W2087623617 cites W4230525567 @default.
- W2087623617 cites W4235798964 @default.
- W2087623617 doi "https://doi.org/10.1016/0002-9343(81)90830-5" @default.
- W2087623617 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6972167" @default.
- W2087623617 hasPublicationYear "1981" @default.
- W2087623617 type Work @default.
- W2087623617 sameAs 2087623617 @default.
- W2087623617 citedByCount "52" @default.
- W2087623617 countsByYear W20876236172018 @default.
- W2087623617 crossrefType "journal-article" @default.
- W2087623617 hasAuthorship W2087623617A5012534523 @default.
- W2087623617 hasAuthorship W2087623617A5058875385 @default.
- W2087623617 hasConcept C126322002 @default.
- W2087623617 hasConcept C141071460 @default.
- W2087623617 hasConcept C2776178081 @default.
- W2087623617 hasConcept C2777559004 @default.
- W2087623617 hasConcept C2777714996 @default.
- W2087623617 hasConcept C2777914695 @default.
- W2087623617 hasConcept C2779425571 @default.
- W2087623617 hasConcept C2779504383 @default.
- W2087623617 hasConcept C2779563453 @default.
- W2087623617 hasConcept C2780728791 @default.
- W2087623617 hasConcept C2993443204 @default.
- W2087623617 hasConcept C501593827 @default.
- W2087623617 hasConcept C71924100 @default.
- W2087623617 hasConcept C86803240 @default.
- W2087623617 hasConcept C89423630 @default.
- W2087623617 hasConceptScore W2087623617C126322002 @default.
- W2087623617 hasConceptScore W2087623617C141071460 @default.
- W2087623617 hasConceptScore W2087623617C2776178081 @default.
- W2087623617 hasConceptScore W2087623617C2777559004 @default.
- W2087623617 hasConceptScore W2087623617C2777714996 @default.
- W2087623617 hasConceptScore W2087623617C2777914695 @default.
- W2087623617 hasConceptScore W2087623617C2779425571 @default.
- W2087623617 hasConceptScore W2087623617C2779504383 @default.
- W2087623617 hasConceptScore W2087623617C2779563453 @default.
- W2087623617 hasConceptScore W2087623617C2780728791 @default.
- W2087623617 hasConceptScore W2087623617C2993443204 @default.
- W2087623617 hasConceptScore W2087623617C501593827 @default.
- W2087623617 hasConceptScore W2087623617C71924100 @default.
- W2087623617 hasConceptScore W2087623617C86803240 @default.
- W2087623617 hasConceptScore W2087623617C89423630 @default.
- W2087623617 hasIssue "6" @default.
- W2087623617 hasLocation W20876236171 @default.
- W2087623617 hasLocation W20876236172 @default.
- W2087623617 hasOpenAccess W2087623617 @default.
- W2087623617 hasPrimaryLocation W20876236171 @default.
- W2087623617 hasRelatedWork W2011525824 @default.
- W2087623617 hasRelatedWork W2023854740 @default.
- W2087623617 hasRelatedWork W2087623617 @default.
- W2087623617 hasRelatedWork W2088543152 @default.
- W2087623617 hasRelatedWork W2410197610 @default.
- W2087623617 hasRelatedWork W2414824402 @default.
- W2087623617 hasRelatedWork W2416477617 @default.
- W2087623617 hasRelatedWork W2416582923 @default.
- W2087623617 hasRelatedWork W2416914487 @default.
- W2087623617 hasRelatedWork W2433899936 @default.
- W2087623617 hasVolume "70" @default.
- W2087623617 isParatext "false" @default.
- W2087623617 isRetracted "false" @default.
- W2087623617 magId "2087623617" @default.
- W2087623617 workType "article" @default.