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- W2087624730 abstract "Abstract Currently, titanium dioxide nanoparticles (TiO 2 NP s) have been widely used in various applications including cosmetics, food additives and biomedicine. However, there are few reports available using TiO 2 NP s to treat ocular diseases. Posterior capsular opacification ( PCO ) is the most frequent complication after cataract surgery, which is induced by the proliferation and migration of lens epithelial cells. Thus, inhibiting the proliferation of lens epithelial cells will efficiently reduce the occurrence of PCO . In this study, we investigated the effects of TiO 2 NP s on HLE B‐3 cells with or without ultraviolet B ( UVB ) irradiation in vitro . We found that TiO 2 NP s can inhibit HLE B‐3 cell growth, cause the elevation of intracellular [Ca 2+ ], produce excessive reactive oxygen species ( ROS ), further reduce Ca 2+ ‐ ATP ase activity and decrease the expression of plasma membrane calcium ATP ase 1 ( PMCA 1), finally disrupt the intracellular calcium homeostasis and induce cell damage. Importantly, UVB irradiation can apparently enhance these effects on HLE B‐3 cells in the presence of TiO 2 NP s. Taken together, the generation of excessive ROS and the disruption of intracellular calcium homeostasis may be both involved in TiO 2 nanoparticle‐induced HLE B‐3 cell damage under UVB irradiation." @default.
- W2087624730 created "2016-06-24" @default.
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- W2087624730 date "2014-09-09" @default.
- W2087624730 modified "2023-10-03" @default.
- W2087624730 title "UVB Irradiation Enhances TiO<sub>2</sub>Nanoparticle-induced Disruption of Calcium Homeostasis in Human Lens Epithelial Cells" @default.
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- W2087624730 doi "https://doi.org/10.1111/php.12322" @default.
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