Matches in SemOpenAlex for { <https://semopenalex.org/work/W2087627032> ?p ?o ?g. }
- W2087627032 endingPage "29" @default.
- W2087627032 startingPage "19" @default.
- W2087627032 abstract "Axon loss in the CNS is characteristic of many neurodegenerative diseases but the mechanisms of axon degeneration are poorly understood. In particular, we know little of the inflammatory response triggered by CNS axon degeneration with comparison to that provoked by death of the neuronal cell body. We show that Wallerian degeneration of the mouse optic nerve induces transcription of TGF-beta1 and TNF-alpha, but not pro-inflammatory cytokines IL-1beta and IL-6 and microglial activation. This atypical inflammatory response resembles macrophages that have phagocytosed apoptotic cells and prion-infected CNS. Significantly, peripheral endotoxin challenge after injury switched this profile by inducing IL-1beta, IL-6 transcripts, other inflammation-associated products and reducing neurofilament immunoreactivity. We propose that microglia are activated by Wallerian degeneration and persist in an atypical but primed state and can be switched by systemic inflammation to provoke a classical pro-inflammatory profile with potentially deleterious consequences." @default.
- W2087627032 created "2016-06-24" @default.
- W2087627032 creator A5007342937 @default.
- W2087627032 creator A5020295667 @default.
- W2087627032 creator A5022720002 @default.
- W2087627032 creator A5024565293 @default.
- W2087627032 creator A5044019815 @default.
- W2087627032 date "2008-04-01" @default.
- W2087627032 modified "2023-10-10" @default.
- W2087627032 title "Systemic inflammation switches the inflammatory cytokine profile in CNS Wallerian degeneration" @default.
- W2087627032 cites W1524627897 @default.
- W2087627032 cites W1532958106 @default.
- W2087627032 cites W1626364985 @default.
- W2087627032 cites W1788332082 @default.
- W2087627032 cites W1965610289 @default.
- W2087627032 cites W1969472473 @default.
- W2087627032 cites W1970606114 @default.
- W2087627032 cites W1972731814 @default.
- W2087627032 cites W1978525572 @default.
- W2087627032 cites W1979413998 @default.
- W2087627032 cites W1979425342 @default.
- W2087627032 cites W1981657664 @default.
- W2087627032 cites W1983280567 @default.
- W2087627032 cites W1983587642 @default.
- W2087627032 cites W1994360619 @default.
- W2087627032 cites W1997962428 @default.
- W2087627032 cites W2005713983 @default.
- W2087627032 cites W2009102898 @default.
- W2087627032 cites W2021571897 @default.
- W2087627032 cites W2029078097 @default.
- W2087627032 cites W2030456435 @default.
- W2087627032 cites W2036284558 @default.
- W2087627032 cites W2038781543 @default.
- W2087627032 cites W2059666688 @default.
- W2087627032 cites W2069560534 @default.
- W2087627032 cites W2074633222 @default.
- W2087627032 cites W2081655354 @default.
- W2087627032 cites W2081791223 @default.
- W2087627032 cites W2082969663 @default.
- W2087627032 cites W2088972398 @default.
- W2087627032 cites W2091493364 @default.
- W2087627032 cites W2091968762 @default.
- W2087627032 cites W2095537212 @default.
- W2087627032 cites W2100728233 @default.
- W2087627032 cites W2101077425 @default.
- W2087627032 cites W2101715019 @default.
- W2087627032 cites W2105294414 @default.
- W2087627032 cites W2107022871 @default.
- W2087627032 cites W2111696577 @default.
- W2087627032 cites W2118118182 @default.
- W2087627032 cites W2124364681 @default.
- W2087627032 cites W2140644257 @default.
- W2087627032 cites W2149200346 @default.
- W2087627032 cites W2150524206 @default.
- W2087627032 cites W2151283331 @default.
- W2087627032 cites W2166298859 @default.
- W2087627032 cites W2170926992 @default.
- W2087627032 cites W4313342476 @default.
- W2087627032 doi "https://doi.org/10.1016/j.nbd.2007.11.012" @default.
- W2087627032 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18255301" @default.
- W2087627032 hasPublicationYear "2008" @default.
- W2087627032 type Work @default.
- W2087627032 sameAs 2087627032 @default.
- W2087627032 citedByCount "94" @default.
- W2087627032 countsByYear W20876270322012 @default.
- W2087627032 countsByYear W20876270322013 @default.
- W2087627032 countsByYear W20876270322014 @default.
- W2087627032 countsByYear W20876270322015 @default.
- W2087627032 countsByYear W20876270322016 @default.
- W2087627032 countsByYear W20876270322017 @default.
- W2087627032 countsByYear W20876270322018 @default.
- W2087627032 countsByYear W20876270322019 @default.
- W2087627032 countsByYear W20876270322020 @default.
- W2087627032 countsByYear W20876270322021 @default.
- W2087627032 countsByYear W20876270322022 @default.
- W2087627032 countsByYear W20876270322023 @default.
- W2087627032 crossrefType "journal-article" @default.
- W2087627032 hasAuthorship W2087627032A5007342937 @default.
- W2087627032 hasAuthorship W2087627032A5020295667 @default.
- W2087627032 hasAuthorship W2087627032A5022720002 @default.
- W2087627032 hasAuthorship W2087627032A5024565293 @default.
- W2087627032 hasAuthorship W2087627032A5044019815 @default.
- W2087627032 hasConcept C169760540 @default.
- W2087627032 hasConcept C203014093 @default.
- W2087627032 hasConcept C2776914184 @default.
- W2087627032 hasConcept C2778690821 @default.
- W2087627032 hasConcept C2779530196 @default.
- W2087627032 hasConcept C2779683492 @default.
- W2087627032 hasConcept C2779830541 @default.
- W2087627032 hasConcept C2780862704 @default.
- W2087627032 hasConcept C529278444 @default.
- W2087627032 hasConcept C86803240 @default.
- W2087627032 hasConcept C87753298 @default.
- W2087627032 hasConceptScore W2087627032C169760540 @default.
- W2087627032 hasConceptScore W2087627032C203014093 @default.
- W2087627032 hasConceptScore W2087627032C2776914184 @default.
- W2087627032 hasConceptScore W2087627032C2778690821 @default.
- W2087627032 hasConceptScore W2087627032C2779530196 @default.