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• W2087628231 abstract "Transcription factor IIIA from S.pombe exhibits a novel structural organization compared to its homologues in other species. TFIIIA from S.cerevisiae or vertebrates contains a total of nine C(2)H(2) zinc-finger domains and a non-zinc finger region at its C terminus. In addition, the S.cerevisiae protein possesses an 81-amino acid spacer between zinc fingers eight and nine. In contrast, the S.pombe TFIIIA sequence includes ten potential zinc finger motifs, with a 53-amino acid spacer between fingers nine and ten. Zinc finger nine of the S.pombe protein deviates from the consensus for a C(2)H(2) zinc finger, however, in that it does not include an appropriately positioned second Zn(2+)-coordinating histidine. We demonstrate here, through analysis of mutated forms of the protein, that the non-canonical ninth zinc finger is functional in both DNA binding and transcription. In addition, we have shown that the spacer preceding finger ten and finger ten itself are essential for the transcriptional function of S.pombe TFIIIA, but neither is required for wild-type 5S rRNA gene-binding activity." @default.
• W2087628231 created "2016-06-24" @default.
• W2087628231 creator A5036844367 @default.
• W2087628231 creator A5062033180 @default.
• W2087628231 date "2003-08-01" @default.
• W2087628231 modified "2023-09-25" @default.
• W2087628231 title "Functional Analysis of the Novel C-terminal Domains of S.pombe Transcription Factor IIIA" @default.
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• W2087628231 doi "https://doi.org/10.1016/s0022-2836(03)00730-7" @default.
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• W2087628231 hasPublicationYear "2003" @default.
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