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• W20876310 abstract "To investigate the sequence requirements for proteolytic processing of prohormones at pairs of basic amino acids, normal and mutant proinsulins were expressed in the mouse pituitary corticotrophic cell line AtT20. The extent of processing was determined by h.p.l.c. analysis of insulin-like immunoreactivity secreted into the media of transfected cells. In this model system, normal proinsulin was efficiently processed to insulin. The mutant des-38-62-proinsulin, in which all but six amino acids of the C-peptide were deleted, was also processed to insulin but less efficiently than the wild-type. The mutant Lys64-Arg65 to Thr64-Arg65 was partially processed to insulin, while the mutant Arg31-Arg32 to Arg31-Gly32 was not processed at either site. These results indicate: (i) that a six-amino-acid spacer between the two pairs of basic amino acids in proinsulin is sufficient to permit processing at both sites; (ii) that the endoproteinase responsible for cleavage at the Lys64-Arg65 site will also recognize Thr64-Arg65; (iii) that the endoproteinase responsible for cleavage at the Arg31-Arg32 site will not recognize Arg31-Gly32; and (iv) that the change Arg31-Arg32 to Arg31-Gly32 affects processing at the Lys64-Arg65 site." @default.
• W20876310 created "2016-06-24" @default.
• W20876310 creator A5008503396 @default.
• W20876310 creator A5061842813 @default.
• W20876310 date "1992-09-01" @default.
• W20876310 modified "2023-10-15" @default.
• W20876310 title "Sequence requirements for processing of proinsulin in transfected mouse pituitary AtT20 cells" @default.
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• W20876310 doi "https://doi.org/10.1042/bj2860619" @default.
• W20876310 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1132943" @default.
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