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• W2087631870 abstract "<h3>Objective:</h3> To assess the presence of cortical lesions (CLs) as detected by MRI in subjects with radiologically isolated syndrome (RIS). <h3>Methods:</h3> Fifteen subjects with RIS underwent an MRI examination, including a double inversion recovery sequence for CL assessment. T2-hyperintense white matter (WM) lesion volume (LV) and normalized volumes of brain and cortex were also obtained. <h3>Results:</h3> Thirty-four CLs were identified in 6 of 15 (40%) subjects with RIS and predominantly distributed in frontotemporal lobes. CLs were frequent in subjects with RIS with immunoglobulin G oligoclonal bands on CSF, cervical cord lesions, and dissemination in time on brain MRI. WM LV was higher in subjects with CLs than in those without CLs (11.5 ± 10.1 vs 3.9 ± 2.8 cm³, <i>p</i> = 0.04). Indeed, CL number and volume correlated with WM LV (<i>r</i> = 0.57, <i>p</i> = 0.03 and <i>r</i> = 0.61, <i>p</i> = 0.01). All subjects with CLs were classified in a previous study as having a very high probability of having relapsing-remitting multiple sclerosis (MS) on a logistic regression analysis of quantitative MRI indices. <h3>Conclusions:</h3> We found CLs in subjects with RIS, a condition characterized by the unanticipated MRI finding of WM lesions highly suggestive of MS in the absence of a clinical scenario. CLs were mainly localized to the frontotemporal lobes and were associated with important markers of evolution to MS." @default.
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• W2087631870 date "2011-11-09" @default.
• W2087631870 modified "2023-09-25" @default.
• W2087631870 title "Cortical lesions in radiologically isolated syndrome" @default.
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• W2087631870 doi "https://doi.org/10.1212/wnl.0b013e318238ee9b" @default.
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