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- W2087634183 abstract "To define the properties of gamma-aminobutyric acid-type A (GABAA) receptors expressed on dentate granule cells in neonatal rats and to define the impact of prolonged seizures on GABAA receptors in 28- to 35-day-old rats.Whole GABAA receptor currents were recorded from acutely isolated dentate granule cells. Cells were isolated from 7- to 14-day-old rats for the first experiment. For the second experiment, cells were isolated from 28- to 35-day-old naive rats and rats that had undergone 45 minutes of status epilepticus. Modulation of GABAA receptor currents by diazepam (DZP), zinc, and zolpidem was studied.In 7- to 14-day-old rats, dentate granule cells express DZP- and zolpidem-insensitive, zinc-sensitive GABAA receptors. In 28- to 35-day-old rats, dentate granule cells express DZP-sensitive GABAA receptors. At the latter age, prolonged seizures render GABAA receptors DZP-insensitive.Hippocampal dentate granule cells express DZP-insensitive receptors in hyperexcitable states. These receptors are likely to contain alpha4 subunit." @default.
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- W2087634183 date "2000-06-01" @default.
- W2087634183 modified "2023-09-27" @default.
- W2087634183 title "Hippocampal Neurons Express GABAA Receptor Insensitive to Diazepam in Hyperexcitable Conditions" @default.
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- W2087634183 doi "https://doi.org/10.1111/j.1528-1157.2000.tb01563.x" @default.
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