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- W2087636623 abstract "A novel method of haplotype identification is discussed allowing simultaneous detection of two adjacent polymorphic sites, a single nucleotide polymorphism (SNP) and a length polymorphism within 1–2 kilobase distance. The method combines allele specific-amplification with high-throughput, automated ultrathin-layer gel electrophoresis analysis of fragment size polymorphism. A typical application is shown for genotyping the –521 C/T single nucleotide polymorphism and the 120 bp duplication in the 5”-upstream region of the dopamine D4 receptor (DRD4) gene. We have also demonstrated that the haplotypes of double heterozygotes for –521 C/T and for the 120 bp duplication can be clearly distinguished, that has only been possible previously by extensive pedigree analysis." @default.
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- W2087636623 date "2002-05-01" @default.
- W2087636623 modified "2023-10-16" @default.
- W2087636623 title "Direct haplotype detection of adjacent polymorphic sites in the regulatory region of the dopamine D4 receptor (DRD4) gene" @default.
- W2087636623 doi "https://doi.org/10.1002/1522-2683(200205)23:10<1512::aid-elps1512>3.0.co;2-b" @default.
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