Matches in SemOpenAlex for { <https://semopenalex.org/work/W2087639596> ?p ?o ?g. }
- W2087639596 endingPage "56" @default.
- W2087639596 startingPage "43" @default.
- W2087639596 abstract "This study was carried out to investigate the effects on the activated partial thromboplastin time test (APTT) when heparin in plasma was neutralized with protamine, Polybrene(R), poly-DL-lysine, or heparin neutralizing activity (HNA) extracted from platelets; or removed by means of the anion exchange resins TEAE cellulose or ECTEOLA cellulose The effect on the APTT of adding the polycations protamine, Polybrene or poly-DL-lysine to citrated plasma was examined. The formation of heparin/polycation complexes was studied by means of their light scattering properties. The low yields of platelet HNA obtained excluded this from practical use as an in vitro heparin antagonist. ECTEOLA cellulose was unable to remove plasma heparin at levels as low as 1 U/ml by the technique employed. TEAE cellulose was able to efficiently remove at least 40 U of heparin from 1 ml of plasma but also caused a non-specific prolongation of the APTT. The polycations protamine, Polybrene, and poly-DL-lysine, possessed clot promoting activity at low concentrations and acted as anticoagulants in their own right at higher concentrations. At a plasma heparin concentration of 4 U/ml, protamine was the most efficient neutralizer of heparin, while at 10 U/ml, Polybrene was the most effective in this respect. It was concluded that care must be taken in the interpretation of the APTT after heparin neutralization or removal as heparin antagonist induced non-specific effects may be present." @default.
- W2087639596 created "2016-06-24" @default.
- W2087639596 creator A5009349390 @default.
- W2087639596 creator A5010850917 @default.
- W2087639596 creator A5020838486 @default.
- W2087639596 creator A5077436481 @default.
- W2087639596 date "1986-01-01" @default.
- W2087639596 modified "2023-10-11" @default.
- W2087639596 title "In vitro neutralization of heparin in plasma prior to the activated partial thromboplastin time test: An assessment of four heparin antagonists and two anion exchange resins" @default.
- W2087639596 cites W1503223519 @default.
- W2087639596 cites W1775749144 @default.
- W2087639596 cites W1968319563 @default.
- W2087639596 cites W1979671775 @default.
- W2087639596 cites W1989515004 @default.
- W2087639596 cites W1995200468 @default.
- W2087639596 cites W1998408111 @default.
- W2087639596 cites W2003632866 @default.
- W2087639596 cites W2007474363 @default.
- W2087639596 cites W2024883271 @default.
- W2087639596 cites W2028290931 @default.
- W2087639596 cites W2060845774 @default.
- W2087639596 cites W2064843116 @default.
- W2087639596 cites W2067121517 @default.
- W2087639596 cites W2073172199 @default.
- W2087639596 cites W2095492586 @default.
- W2087639596 cites W2112274804 @default.
- W2087639596 cites W2125099932 @default.
- W2087639596 cites W2317139092 @default.
- W2087639596 cites W2317153803 @default.
- W2087639596 cites W2317329910 @default.
- W2087639596 cites W2404565061 @default.
- W2087639596 cites W2419561014 @default.
- W2087639596 cites W2324916790 @default.
- W2087639596 doi "https://doi.org/10.1016/0049-3848(86)90278-1" @default.
- W2087639596 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3961726" @default.
- W2087639596 hasPublicationYear "1986" @default.
- W2087639596 type Work @default.
- W2087639596 sameAs 2087639596 @default.
- W2087639596 citedByCount "26" @default.
- W2087639596 countsByYear W20876395962013 @default.
- W2087639596 countsByYear W20876395962016 @default.
- W2087639596 countsByYear W20876395962017 @default.
- W2087639596 countsByYear W20876395962019 @default.
- W2087639596 countsByYear W20876395962023 @default.
- W2087639596 crossrefType "journal-article" @default.
- W2087639596 hasAuthorship W2087639596A5009349390 @default.
- W2087639596 hasAuthorship W2087639596A5010850917 @default.
- W2087639596 hasAuthorship W2087639596A5020838486 @default.
- W2087639596 hasAuthorship W2087639596A5077436481 @default.
- W2087639596 hasConcept C126322002 @default.
- W2087639596 hasConcept C14086860 @default.
- W2087639596 hasConcept C159654299 @default.
- W2087639596 hasConcept C185592680 @default.
- W2087639596 hasConcept C202751555 @default.
- W2087639596 hasConcept C203014093 @default.
- W2087639596 hasConcept C2777557582 @default.
- W2087639596 hasConcept C2778205648 @default.
- W2087639596 hasConcept C2778261982 @default.
- W2087639596 hasConcept C2779251873 @default.
- W2087639596 hasConcept C2780835560 @default.
- W2087639596 hasConcept C43617362 @default.
- W2087639596 hasConcept C55493867 @default.
- W2087639596 hasConcept C71924100 @default.
- W2087639596 hasConcept C89560881 @default.
- W2087639596 hasConcept C98274493 @default.
- W2087639596 hasConceptScore W2087639596C126322002 @default.
- W2087639596 hasConceptScore W2087639596C14086860 @default.
- W2087639596 hasConceptScore W2087639596C159654299 @default.
- W2087639596 hasConceptScore W2087639596C185592680 @default.
- W2087639596 hasConceptScore W2087639596C202751555 @default.
- W2087639596 hasConceptScore W2087639596C203014093 @default.
- W2087639596 hasConceptScore W2087639596C2777557582 @default.
- W2087639596 hasConceptScore W2087639596C2778205648 @default.
- W2087639596 hasConceptScore W2087639596C2778261982 @default.
- W2087639596 hasConceptScore W2087639596C2779251873 @default.
- W2087639596 hasConceptScore W2087639596C2780835560 @default.
- W2087639596 hasConceptScore W2087639596C43617362 @default.
- W2087639596 hasConceptScore W2087639596C55493867 @default.
- W2087639596 hasConceptScore W2087639596C71924100 @default.
- W2087639596 hasConceptScore W2087639596C89560881 @default.
- W2087639596 hasConceptScore W2087639596C98274493 @default.
- W2087639596 hasIssue "1" @default.
- W2087639596 hasLocation W20876395961 @default.
- W2087639596 hasLocation W20876395962 @default.
- W2087639596 hasOpenAccess W2087639596 @default.
- W2087639596 hasPrimaryLocation W20876395961 @default.
- W2087639596 hasRelatedWork W173534854 @default.
- W2087639596 hasRelatedWork W1980832026 @default.
- W2087639596 hasRelatedWork W2023619243 @default.
- W2087639596 hasRelatedWork W2025062353 @default.
- W2087639596 hasRelatedWork W2411561722 @default.
- W2087639596 hasRelatedWork W2904197175 @default.
- W2087639596 hasRelatedWork W4323284267 @default.
- W2087639596 hasRelatedWork W4386743610 @default.
- W2087639596 hasRelatedWork W174166667 @default.
- W2087639596 hasRelatedWork W2027795091 @default.
- W2087639596 hasVolume "41" @default.
- W2087639596 isParatext "false" @default.