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• W2087644329 abstract "Experimental infection of mice with Helicobacter felis reproduces many aspects of the gastritis observed in Helicobacter pylori-infected humans. The development of gastric inflammatory lesions in chronically infected inbred mice is host-dependent; in BALB/c mice, gastric B-cell MALT lymphomas were observed, whilst other murine hosts (e.g. C57BL/6) developed severe glandular hyperplasia. The aims of this investigation were to characterize and immunophenotype Helicobacter-induced inflammatory lesions in mice with an outbred genetic background. Swiss mice (n=10 per group) were either inoculated with a suspension of H. felis or left untreated. H. felis-inoculated mice and age-matched control animals were killed 13 months later. The severity of gastric inflammatory lesions in the animals was graded and the number and distribution of B (CD45R+) and T (CD3+) lymphocytes in lymphoid tissues was determined by immunohistochemistry. Compared with control mice, animals with long-term H. felis infection developed severe hyperplastic gastritis (0.80±0.63 vs. 2.7±0.68), with epithelial dedifferentiation (0.40±0.52 vs. 2.3±0.82) and lengthening of the pits and glands (0.46±0.05 vs. 0.8±0.19). Gastric CD45R+ and CD3+ lymphocyte scores were significantly elevated (r=0.803) in infected animals, while lymphoepithelial lesions and polymorphonuclear leucocyte infiltrates were absent. Although prominent lymphoid follicles were present in the tissues of all infected animals, and in one control animal, only a proportion (55%) of the mucosal follicles had a dominant B-cell phenotype (defined as ≥75% CD45R+ labelling), and all were poorly labelled with anti-mouse immunoglobulin antibodies. It was concluded that the lesions in outbred Swiss mice differed from B-cell MALT lymphomas. In contrast to inbred mice, outbred animals developed both glandular and lymphoid tissue lesions to chronic H. felis infection. It is suggested that the default T-helper phenotype of the host influences glandular lesion formation or B-cell lymphomagenesis in this model of infection. Copyright © 2000 John Wiley & Sons, Ltd." @default.
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• W2087644329 date "2000-01-01" @default.
• W2087644329 modified "2023-10-16" @default.
• W2087644329 title "Outbred mice with long-termHelicobacter felis infection develop both gastric lymphoid tissue and glandular hyperplastic lesions" @default.
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• W2087644329 doi "https://doi.org/10.1002/1096-9896(2000)9999:9999<::aid-path619>3.0.co;2-h" @default.
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