FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2087647272> ?p ?o ?g. }

• W2087647272 endingPage "1270" @default.
• W2087647272 startingPage "1258" @default.
• W2087647272 abstract "Chronic lymphocytic leukemia (CLL) is the most prevalent leukemia in the western world. Recent advances in understanding the biology of B-cell malignancies have resulted in the development of novel agents targeting key prosurvival pathways in the neoplastic B cell.The goal of this article was to summarize current literature on the emerging therapeutic approaches in CLL and B-cell malignancies.A literature review was performed, identifying pathways and key clinical trials involving novel therapies in CLL, with special emphasis on B-cell receptor (BCR)-targeting agents.Understanding the biology of the BCR-signaling pathway has led to identification of novel molecular targets. Most notably, inhibitors of Bruton tyrosine kinase and phosphatidylinositide 3-kinase-δ have entered clinical trials and demonstrated high response rates in CLL, including high-risk disease. Cyclin-dependent kinase inhibitors may evolve into an alternative therapeutic approach in CLL. New drugs that target molecules within and outside of the BCR-signaling pathway have shown promise in preclinical studies.Both preclinical and early clinical trial results involving novel targeted therapies suggest that the standard treatment paradigm in CLL and B-cell malignancies will soon change. Particular attention should be paid to the BCR-targeting agents, whose favorable adverse effect profile may improve the lives of elderly patients with CLL." @default.
• W2087647272 created "2016-06-24" @default.
• W2087647272 creator A5067633124 @default.
• W2087647272 date "2013-09-01" @default.
• W2087647272 modified "2023-10-18" @default.
• W2087647272 title "Targeted Therapy in Chronic Lymphocytic Leukemia: Past, Present, and Future" @default.
• W2087647272 cites W1514528460 @default.
• W2087647272 cites W1522773084 @default.
• W2087647272 cites W1551073524 @default.
• W2087647272 cites W1915689252 @default.
• W2087647272 cites W1965344560 @default.
• W2087647272 cites W1971163722 @default.
• W2087647272 cites W1972564258 @default.
• W2087647272 cites W1976015013 @default.
• W2087647272 cites W1976402300 @default.
• W2087647272 cites W1984046622 @default.
• W2087647272 cites W1988682601 @default.
• W2087647272 cites W1988703453 @default.
• W2087647272 cites W1990986028 @default.
• W2087647272 cites W1994740077 @default.
• W2087647272 cites W1997782547 @default.
• W2087647272 cites W1999782555 @default.
• W2087647272 cites W2001850157 @default.
• W2087647272 cites W2004473774 @default.
• W2087647272 cites W2019625224 @default.
• W2087647272 cites W2019655196 @default.
• W2087647272 cites W2021494482 @default.
• W2087647272 cites W2025786205 @default.
• W2087647272 cites W2029903885 @default.
• W2087647272 cites W2033315156 @default.
• W2087647272 cites W2038053631 @default.
• W2087647272 cites W2040604274 @default.
• W2087647272 cites W2044556191 @default.
• W2087647272 cites W2045182309 @default.
• W2087647272 cites W2045608879 @default.
• W2087647272 cites W2047247432 @default.
• W2087647272 cites W2049070107 @default.
• W2087647272 cites W2060508679 @default.
• W2087647272 cites W2062980622 @default.
• W2087647272 cites W2066107979 @default.
• W2087647272 cites W2076544158 @default.
• W2087647272 cites W2076690627 @default.
• W2087647272 cites W2080939719 @default.
• W2087647272 cites W2088580309 @default.
• W2087647272 cites W2088591622 @default.
• W2087647272 cites W2095408122 @default.
• W2087647272 cites W2095726706 @default.
• W2087647272 cites W2099348990 @default.
• W2087647272 cites W2099944032 @default.
• W2087647272 cites W2100772783 @default.
• W2087647272 cites W2108726442 @default.
• W2087647272 cites W2109442096 @default.
• W2087647272 cites W2114847222 @default.
• W2087647272 cites W2116090592 @default.
• W2087647272 cites W2116262245 @default.
• W2087647272 cites W2120380960 @default.
• W2087647272 cites W2120535935 @default.
• W2087647272 cites W2121545240 @default.
• W2087647272 cites W2125134816 @default.
• W2087647272 cites W2125877270 @default.
• W2087647272 cites W2126442701 @default.
• W2087647272 cites W2130610418 @default.
• W2087647272 cites W2135270635 @default.
• W2087647272 cites W2135781988 @default.
• W2087647272 cites W2139771411 @default.
• W2087647272 cites W2140642045 @default.
• W2087647272 cites W2142099365 @default.
• W2087647272 cites W2142184993 @default.
• W2087647272 cites W2142923221 @default.
• W2087647272 cites W2144935474 @default.
• W2087647272 cites W2154022654 @default.
• W2087647272 cites W2159982252 @default.
• W2087647272 cites W2166526425 @default.
• W2087647272 cites W2167292349 @default.
• W2087647272 cites W2168215118 @default.
• W2087647272 cites W2242208648 @default.
• W2087647272 cites W2275948481 @default.
• W2087647272 cites W2323897083 @default.
• W2087647272 cites W2326175431 @default.
• W2087647272 cites W2413917663 @default.
• W2087647272 cites W2536134588 @default.
• W2087647272 cites W2547502956 @default.
• W2087647272 cites W2553910750 @default.
• W2087647272 cites W2560550453 @default.
• W2087647272 cites W2572326728 @default.
• W2087647272 cites W2573861971 @default.
• W2087647272 cites W2580497378 @default.
• W2087647272 cites W2588919636 @default.
• W2087647272 cites W2592226531 @default.
• W2087647272 cites W2592558314 @default.
• W2087647272 cites W2980054803 @default.
• W2087647272 cites W4245949927 @default.
• W2087647272 cites W4376595664 @default.
• W2087647272 cites W69058593 @default.
• W2087647272 cites W8604280 @default.
• W2087647272 doi "https://doi.org/10.1016/j.clinthera.2013.08.004" @default.
• W2087647272 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3880015" @default.
• W2087647272 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24054703" @default.

• next