Matches in SemOpenAlex for { <https://semopenalex.org/work/W2087647596> ?p ?o ?g. }
- W2087647596 endingPage "4564" @default.
- W2087647596 startingPage "4564" @default.
- W2087647596 abstract "To characterize progressive changes of retinal ganglion cell (RGC) function and intraocular pressure (IOP) in the DBA/2J mouse model of spontaneous glaucoma.Serial pattern electroretinograms (PERGs) and IOPs measures were obtained from both eyes of 32 anesthetized DBA/2J mice over an age range of 2 to 12 months at 1-month intervals. Cone-driven flash-ERGs (FERGs) were also recorded. The endpoint was defined as the age at which the PERG amplitude reached the noise level in at least one eye. At that point, both eyes were histologically processed to evaluate the thickness of the retinal fiber layer (RNFL).IOP increased moderately between 2 and 6 months ( approximately 14-17 mm Hg) and then more steeply, until it leveled off at approximately 28 mm Hg by 9 to 11 months. The mean PERG amplitude decreased progressively after 3 months of age to reach the noise level (85% reduction of normal amplitude) at approximately 9 to 12 months in different animals. When the PERG was at noise level, the RNFL showed a relatively smaller reduction (40%) in normal thickness. The FERG displayed minor changes throughout the observation period. IOP and PERG changes were highly correlated (r(2) = 0.51, P < 0.001).Results indicate that inner retina function in DBA/2J mice progressively decreases after 3 months of age, and it is nearly abolished by 10 to 11 months, whereas outer retina function shows little change and the RNFL thickness is relatively spared. This result suggests that surviving RGCs may not be functional. Progression of inner retinal dysfunction is strongly associated with increased IOP." @default.
- W2087647596 created "2016-06-24" @default.
- W2087647596 creator A5054390622 @default.
- W2087647596 creator A5081573579 @default.
- W2087647596 creator A5084191707 @default.
- W2087647596 date "2007-10-01" @default.
- W2087647596 modified "2023-10-18" @default.
- W2087647596 title "Longitudinal Evaluation of Retinal Ganglion Cell Function and IOP in the DBA/2J Mouse Model of Glaucoma" @default.
- W2087647596 cites W1496968788 @default.
- W2087647596 cites W1518325522 @default.
- W2087647596 cites W1525118283 @default.
- W2087647596 cites W1552605193 @default.
- W2087647596 cites W1553218248 @default.
- W2087647596 cites W1559495569 @default.
- W2087647596 cites W1572668934 @default.
- W2087647596 cites W1574402411 @default.
- W2087647596 cites W1575402497 @default.
- W2087647596 cites W1578199258 @default.
- W2087647596 cites W1607410253 @default.
- W2087647596 cites W1624993595 @default.
- W2087647596 cites W1785865236 @default.
- W2087647596 cites W18326312 @default.
- W2087647596 cites W1964675499 @default.
- W2087647596 cites W1969950010 @default.
- W2087647596 cites W1970428486 @default.
- W2087647596 cites W1975661596 @default.
- W2087647596 cites W1975731265 @default.
- W2087647596 cites W1978392572 @default.
- W2087647596 cites W1980324629 @default.
- W2087647596 cites W1982845356 @default.
- W2087647596 cites W1984401984 @default.
- W2087647596 cites W1985688303 @default.
- W2087647596 cites W1987876121 @default.
- W2087647596 cites W1991685992 @default.
- W2087647596 cites W1992902368 @default.
- W2087647596 cites W1993968998 @default.
- W2087647596 cites W1994986394 @default.
- W2087647596 cites W1998545339 @default.
- W2087647596 cites W2005127845 @default.
- W2087647596 cites W2008043586 @default.
- W2087647596 cites W2008975983 @default.
- W2087647596 cites W2009091430 @default.
- W2087647596 cites W2009740514 @default.
- W2087647596 cites W2012101359 @default.
- W2087647596 cites W2012389637 @default.
- W2087647596 cites W2013785821 @default.
- W2087647596 cites W2014878702 @default.
- W2087647596 cites W2015999797 @default.
- W2087647596 cites W2019885109 @default.
- W2087647596 cites W2020186276 @default.
- W2087647596 cites W2021751894 @default.
- W2087647596 cites W2021933371 @default.
- W2087647596 cites W2022209206 @default.
- W2087647596 cites W2023281063 @default.
- W2087647596 cites W2024753181 @default.
- W2087647596 cites W2026733101 @default.
- W2087647596 cites W2026895146 @default.
- W2087647596 cites W2030407532 @default.
- W2087647596 cites W2034679694 @default.
- W2087647596 cites W2037824551 @default.
- W2087647596 cites W2040275472 @default.
- W2087647596 cites W2041316820 @default.
- W2087647596 cites W2043923159 @default.
- W2087647596 cites W2047510146 @default.
- W2087647596 cites W2049448622 @default.
- W2087647596 cites W2049677403 @default.
- W2087647596 cites W2050174076 @default.
- W2087647596 cites W2053567524 @default.
- W2087647596 cites W2055335620 @default.
- W2087647596 cites W2057266151 @default.
- W2087647596 cites W2060612533 @default.
- W2087647596 cites W2062523245 @default.
- W2087647596 cites W2073392343 @default.
- W2087647596 cites W2073452663 @default.
- W2087647596 cites W2082567274 @default.
- W2087647596 cites W2082737510 @default.
- W2087647596 cites W2092709998 @default.
- W2087647596 cites W2111090514 @default.
- W2087647596 cites W2129843248 @default.
- W2087647596 cites W2135364731 @default.
- W2087647596 cites W2135930638 @default.
- W2087647596 cites W2137720344 @default.
- W2087647596 cites W2142011909 @default.
- W2087647596 cites W2143472502 @default.
- W2087647596 cites W214785570 @default.
- W2087647596 cites W2148683835 @default.
- W2087647596 cites W2157890401 @default.
- W2087647596 cites W2192786661 @default.
- W2087647596 cites W2325896885 @default.
- W2087647596 cites W2402631017 @default.
- W2087647596 cites W2416424973 @default.
- W2087647596 cites W2426769575 @default.
- W2087647596 cites W2442474394 @default.
- W2087647596 cites W2625521663 @default.
- W2087647596 cites W2977587116 @default.
- W2087647596 cites W52563575 @default.
- W2087647596 doi "https://doi.org/10.1167/iovs.07-0483" @default.
- W2087647596 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2765717" @default.