Matches in SemOpenAlex for { <https://semopenalex.org/work/W2087654007> ?p ?o ?g. }
- W2087654007 endingPage "93" @default.
- W2087654007 startingPage "85" @default.
- W2087654007 abstract "Cells migrating through a tissue exert force via their cytoskeleton and are themselves subject to tension, but the effects of physical forces on cell behavior in vivo are poorly understood. Border cell migration during Drosophila oogenesis is a useful model for invasive cell movement. We report that this migration requires the activity of the transcriptional factor serum response factor (SRF) and its cofactor MAL-D and present evidence that nuclear accumulation of MAL-D is induced by cell stretching. Border cells that cannot migrate lack nuclear MAL-D but can accumulate it if they are pulled by other migrating cells. Like mammalian MAL, MAL-D also responds to activated Diaphanous, which affects actin dynamics. MAL-D/SRF activity is required to build a robust actin cytoskeleton in the migrating cells; mutant cells break apart when initiating migration. Thus, tension-induced MAL-D activity may provide a feedback mechanism for enhancing cytoskeletal strength during invasive migration." @default.
- W2087654007 created "2016-06-24" @default.
- W2087654007 creator A5069467026 @default.
- W2087654007 creator A5074649116 @default.
- W2087654007 date "2004-07-01" @default.
- W2087654007 modified "2023-10-18" @default.
- W2087654007 title "Evidence for Tension-Based Regulation of Drosophila MAL and SRF during Invasive Cell Migration" @default.
- W2087654007 cites W1525509607 @default.
- W2087654007 cites W1538619419 @default.
- W2087654007 cites W1845241435 @default.
- W2087654007 cites W1975971309 @default.
- W2087654007 cites W1983096415 @default.
- W2087654007 cites W1995380251 @default.
- W2087654007 cites W1996068610 @default.
- W2087654007 cites W1996487201 @default.
- W2087654007 cites W1997524493 @default.
- W2087654007 cites W2003736664 @default.
- W2087654007 cites W2008297562 @default.
- W2087654007 cites W2019109537 @default.
- W2087654007 cites W2023687572 @default.
- W2087654007 cites W2026652581 @default.
- W2087654007 cites W2028776361 @default.
- W2087654007 cites W2047531031 @default.
- W2087654007 cites W2057708838 @default.
- W2087654007 cites W2066347300 @default.
- W2087654007 cites W2077536021 @default.
- W2087654007 cites W2087575288 @default.
- W2087654007 cites W2089759608 @default.
- W2087654007 cites W2093723806 @default.
- W2087654007 cites W2095065858 @default.
- W2087654007 cites W2096628719 @default.
- W2087654007 cites W2097653816 @default.
- W2087654007 cites W2102978118 @default.
- W2087654007 cites W2103288036 @default.
- W2087654007 cites W2104980653 @default.
- W2087654007 cites W2114469101 @default.
- W2087654007 cites W2123110782 @default.
- W2087654007 cites W2125509960 @default.
- W2087654007 cites W2131219323 @default.
- W2087654007 cites W2132332604 @default.
- W2087654007 cites W2132705463 @default.
- W2087654007 cites W2132823963 @default.
- W2087654007 cites W2140786734 @default.
- W2087654007 cites W2141075109 @default.
- W2087654007 cites W2142501126 @default.
- W2087654007 cites W2145183379 @default.
- W2087654007 cites W2145354091 @default.
- W2087654007 cites W2152376785 @default.
- W2087654007 cites W2158253639 @default.
- W2087654007 cites W2165537590 @default.
- W2087654007 doi "https://doi.org/10.1016/j.devcel.2004.05.020" @default.
- W2087654007 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15239956" @default.
- W2087654007 hasPublicationYear "2004" @default.
- W2087654007 type Work @default.
- W2087654007 sameAs 2087654007 @default.
- W2087654007 citedByCount "174" @default.
- W2087654007 countsByYear W20876540072012 @default.
- W2087654007 countsByYear W20876540072013 @default.
- W2087654007 countsByYear W20876540072014 @default.
- W2087654007 countsByYear W20876540072015 @default.
- W2087654007 countsByYear W20876540072016 @default.
- W2087654007 countsByYear W20876540072017 @default.
- W2087654007 countsByYear W20876540072018 @default.
- W2087654007 countsByYear W20876540072019 @default.
- W2087654007 countsByYear W20876540072020 @default.
- W2087654007 countsByYear W20876540072021 @default.
- W2087654007 countsByYear W20876540072022 @default.
- W2087654007 countsByYear W20876540072023 @default.
- W2087654007 crossrefType "journal-article" @default.
- W2087654007 hasAuthorship W2087654007A5069467026 @default.
- W2087654007 hasAuthorship W2087654007A5074649116 @default.
- W2087654007 hasBestOaLocation W20876540071 @default.
- W2087654007 hasConcept C104317684 @default.
- W2087654007 hasConcept C125705527 @default.
- W2087654007 hasConcept C137738243 @default.
- W2087654007 hasConcept C142669718 @default.
- W2087654007 hasConcept C1491633281 @default.
- W2087654007 hasConcept C2993400109 @default.
- W2087654007 hasConcept C54355233 @default.
- W2087654007 hasConcept C69053785 @default.
- W2087654007 hasConcept C86339819 @default.
- W2087654007 hasConcept C86803240 @default.
- W2087654007 hasConcept C95444343 @default.
- W2087654007 hasConceptScore W2087654007C104317684 @default.
- W2087654007 hasConceptScore W2087654007C125705527 @default.
- W2087654007 hasConceptScore W2087654007C137738243 @default.
- W2087654007 hasConceptScore W2087654007C142669718 @default.
- W2087654007 hasConceptScore W2087654007C1491633281 @default.
- W2087654007 hasConceptScore W2087654007C2993400109 @default.
- W2087654007 hasConceptScore W2087654007C54355233 @default.
- W2087654007 hasConceptScore W2087654007C69053785 @default.
- W2087654007 hasConceptScore W2087654007C86339819 @default.
- W2087654007 hasConceptScore W2087654007C86803240 @default.
- W2087654007 hasConceptScore W2087654007C95444343 @default.
- W2087654007 hasIssue "1" @default.
- W2087654007 hasLocation W20876540071 @default.
- W2087654007 hasLocation W20876540072 @default.
- W2087654007 hasOpenAccess W2087654007 @default.