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• W2087654606 abstract "This study compared the relative role of insulin resistance and β-cell dysfunction (both assessed using the HOMA method) with glucose intolerance conditions in the progression to type 2 diabetes among a high risk group of subjects with fasting plasma glucose (FPG) 5.6–7.0 mmol/l in Kinmen, Taiwan. Data were collected during a continuing prospective study (1998–99) of a group of Taiwanese subjects at high-risk of developing type 2 diabetes who had fasting hyperglycemia (5.6–7.0 mmol/l) and exhibited 2-h postload glucose concentrations <11.1 mmol/l from 1992–94 to 1995–96. Among 644 non-diabetic subjects at baseline, 79.8% (514/644) had at least one follow-up examination. There were 107 new cases of diabetes diagnosed by 1999 WHO criteria in 2918.7 person-years of follow-up. The incidence rate was 3.67%/year (107/2918.7). After adjustment for other possible associative variables, including gender, age, BMI, waist circumference, insulin resistance, and β-cell dysfunction, Cox's hazard model showed that those individuals with isolated IFG (impaired fasting glucose) and those individuals with isolated IGT (2-h glucose impairment) exhibited similar risk of developing diabetes. Those individuals with isolated IFG and isolated IGT showed a comparable impairment of basal or hepatic insulin sensitivity, but those individuals with isolated IFG had a greater β-cell dysfunction by the HOMA method." @default.
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• W2087654606 date "2003-03-01" @default.
• W2087654606 modified "2023-10-11" @default.
• W2087654606 title "Relative role of insulin resistance and β-cell dysfunction in the progression to type 2 diabetes—The Kinmen Study" @default.
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• W2087654606 doi "https://doi.org/10.1016/s0168-8227(02)00249-8" @default.
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