FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2087655840> ?p ?o ?g. }

• W2087655840 endingPage "1334" @default.
• W2087655840 startingPage "1334" @default.
• W2087655840 abstract "The urokinase-mediated plasminogen activation (uPA) system plays a central role in a number of cellular processes including tissue remodeling, cell migration, and angiogenesis. Elevated uPA activity has also been seen with tumor invasion and metastasis in a variety of malignancies. Keloids represent an aberrant form of wound healing characterized by uncontrolled growth with invasion beyond the margins of the original wound. The regulation of this cellular process remains poorly understood. We hypothesize that keloids will have increased staining percentage for uPA and its receptor (uPAR) compared with normal scars. To our knowledge, no previous studies have examined the relationship of uPAR in keloid formation.Analysis of uPAR expression by immunohistochemistry in paraffin sections from 20 keloids and 18 normal scars. Expression was graded by a dermatopathologist according to percentage of cells staining for uPAR.University Medical Center (Division of Otolaryngology-Head and Neck Surgery) and the Department of Dermatology at the University of Rochester Medical and Dental School, Rochester, NY.Of the 20 keloids, 8 (40%) strongly expressed uPAR (>50% of cells), while only 4 (22%) of 18 normal scars had similar staining. More than half of the normal scars stained minimally for uPAR (<5% staining). There was a strong expression of uPAR in the extracellular matrix in 14 (70%) of the 20 keloids, while no scar showed uPAR in the extracellular matrix.Our observation suggests that the uPA system is involved in the expansion of keloids beyond the wound margins in part through the degradation of the extracellular matrix, a finding that is supported by the strong expression of uPAR in the extracellular matrix and collagenous cords in most keloids studied." @default.
• W2087655840 created "2016-06-24" @default.
• W2087655840 creator A5020102834 @default.
• W2087655840 creator A5068513165 @default.
• W2087655840 creator A5055288786 @default.
• W2087655840 date "2003-12-01" @default.
• W2087655840 modified "2023-09-27" @default.
• W2087655840 title "Expression of Urokinase-type Plasminogen Activator and Its Receptor in Keloids" @default.
• W2087655840 cites W104285953 @default.
• W2087655840 cites W148753544 @default.
• W2087655840 cites W1633360475 @default.
• W2087655840 cites W1975951635 @default.
• W2087655840 cites W1997159217 @default.
• W2087655840 cites W1999708653 @default.
• W2087655840 cites W2014086967 @default.
• W2087655840 cites W2018687452 @default.
• W2087655840 cites W2021479539 @default.
• W2087655840 cites W2026151657 @default.
• W2087655840 cites W2027066293 @default.
• W2087655840 cites W2027636267 @default.
• W2087655840 cites W2031986861 @default.
• W2087655840 cites W2039190542 @default.
• W2087655840 cites W2057831694 @default.
• W2087655840 cites W2064657225 @default.
• W2087655840 cites W2065727101 @default.
• W2087655840 cites W2067894328 @default.
• W2087655840 cites W2073028076 @default.
• W2087655840 cites W2089693544 @default.
• W2087655840 cites W2093136003 @default.
• W2087655840 cites W2125190135 @default.
• W2087655840 cites W2129517367 @default.
• W2087655840 cites W2132207764 @default.
• W2087655840 cites W2166444942 @default.
• W2087655840 cites W23122061 @default.
• W2087655840 cites W2401236594 @default.
• W2087655840 cites W2411316146 @default.
• W2087655840 cites W2419488856 @default.
• W2087655840 cites W38263071 @default.
• W2087655840 doi "https://doi.org/10.1001/archotol.129.12.1334" @default.
• W2087655840 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14676162" @default.
• W2087655840 hasPublicationYear "2003" @default.
• W2087655840 type Work @default.
• W2087655840 sameAs 2087655840 @default.
• W2087655840 citedByCount "13" @default.
• W2087655840 countsByYear W20876558402012 @default.
• W2087655840 countsByYear W20876558402013 @default.
• W2087655840 countsByYear W20876558402015 @default.
• W2087655840 countsByYear W20876558402016 @default.
• W2087655840 countsByYear W20876558402020 @default.
• W2087655840 crossrefType "journal-article" @default.
• W2087655840 hasAuthorship W2087655840A5020102834 @default.
• W2087655840 hasAuthorship W2087655840A5055288786 @default.
• W2087655840 hasAuthorship W2087655840A5068513165 @default.
• W2087655840 hasBestOaLocation W20876558401 @default.
• W2087655840 hasConcept C126322002 @default.
• W2087655840 hasConcept C142724271 @default.
• W2087655840 hasConcept C189165786 @default.
• W2087655840 hasConcept C203014093 @default.
• W2087655840 hasConcept C204232928 @default.
• W2087655840 hasConcept C2777538232 @default.
• W2087655840 hasConcept C2777642821 @default.
• W2087655840 hasConcept C2779679481 @default.
• W2087655840 hasConcept C2780269544 @default.
• W2087655840 hasConcept C2780394083 @default.
• W2087655840 hasConcept C502942594 @default.
• W2087655840 hasConcept C56219504 @default.
• W2087655840 hasConcept C71924100 @default.
• W2087655840 hasConcept C74864618 @default.
• W2087655840 hasConcept C86803240 @default.
• W2087655840 hasConcept C95444343 @default.
• W2087655840 hasConceptScore W2087655840C126322002 @default.
• W2087655840 hasConceptScore W2087655840C142724271 @default.
• W2087655840 hasConceptScore W2087655840C189165786 @default.
• W2087655840 hasConceptScore W2087655840C203014093 @default.
• W2087655840 hasConceptScore W2087655840C204232928 @default.
• W2087655840 hasConceptScore W2087655840C2777538232 @default.
• W2087655840 hasConceptScore W2087655840C2777642821 @default.
• W2087655840 hasConceptScore W2087655840C2779679481 @default.
• W2087655840 hasConceptScore W2087655840C2780269544 @default.
• W2087655840 hasConceptScore W2087655840C2780394083 @default.
• W2087655840 hasConceptScore W2087655840C502942594 @default.
• W2087655840 hasConceptScore W2087655840C56219504 @default.
• W2087655840 hasConceptScore W2087655840C71924100 @default.
• W2087655840 hasConceptScore W2087655840C74864618 @default.
• W2087655840 hasConceptScore W2087655840C86803240 @default.
• W2087655840 hasConceptScore W2087655840C95444343 @default.
• W2087655840 hasIssue "12" @default.
• W2087655840 hasLocation W20876558401 @default.
• W2087655840 hasLocation W20876558402 @default.
• W2087655840 hasOpenAccess W2087655840 @default.
• W2087655840 hasPrimaryLocation W20876558401 @default.
• W2087655840 hasRelatedWork W2028238745 @default.
• W2087655840 hasRelatedWork W2035464821 @default.
• W2087655840 hasRelatedWork W2080607837 @default.
• W2087655840 hasRelatedWork W2084573400 @default.
• W2087655840 hasRelatedWork W2143804510 @default.
• W2087655840 hasRelatedWork W2188814450 @default.
• W2087655840 hasRelatedWork W2375381614 @default.

• next