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• W2087658519 abstract "The ommatidia of the Drosophila eye initiate development by stepwise recruitment of photoreceptors into symmetric ommatidial clusters. As they mature, the clusters become asymmetric, adopting opposite chirality on either side of the dorsoventral midline and rotating exactly 90° (Figures 1A and 1B, [1Wolff T. Ready D.F. Pattern formation in the Drosophila retina.in: Bate M. Martinez-Arias A. The Development of Drosophila melanogaster. Cold Spring Harbor Press, Cold Spring Harbor1993Google Scholar]). The choice of chirality is governed by higher activity of the frizzled (fz) gene in one cell of the R3/R4 photoreceptor pair [2Zheng L. Zhang J. Carthew R.W. frizzled regulates mirror-symmetric pattern formation in the Drosophila eye.Development. 1995; 121: 3045-3055PubMed Google Scholar] and by Notch-Delta (N-Dl) signaling [3Cooper M.Y. Bray S.J. Frizzled regulation of Notch signalling polarizes cell fate in the Drosophila eye.Nature. 1999; 397: 526-530Crossref PubMed Scopus (204) Google Scholar, 4Fanto M. Mlodzik M. Asymmetric Notch activation specifies photoreceptors R3 and R4 and planar polarity in the Drosophila eye.Nature. 1999; 397: 523-526Crossref PubMed Scopus (179) Google Scholar, 5Tomlinson A. Struhl G. Decoding vectorial information from a gradient sequential roles of the receptors Frizzled and Notch in establishing planar polarity in the Drosophila eye.Development. 1999; 126: 5725-5738PubMed Google Scholar]. The 90° rotation also requires activity of planar polarity genes such as fz as well as the roulette (rlt) locus [2Zheng L. Zhang J. Carthew R.W. frizzled regulates mirror-symmetric pattern formation in the Drosophila eye.Development. 1995; 121: 3045-3055PubMed Google Scholar, 6Choi K.W. Benzer S. Rotation of photoreceptor clusters in the developing Drosophila eye requires the nemo gene.Cell. 1994; 78: 125-136Abstract Full Text PDF PubMed Scopus (153) Google Scholar]. We now show that two regulators of EGF signaling, argos and sprouty (sty), and a gain-of-function Ras85D allele, interact genetically with fz in ommatidial polarity. Furthermore, we find that argos is required for ommatidial rotation, but not chirality, and that rlt is a novel allele of argos. We present evidence that there are two pathways by which EGF signaling affects ommatidial rotation. In the first, typified by the rlt phenotype, there is partial transformation of the “mystery cells” toward a neuronal fate. Although most of these mystery cells subsequently fail to develop as neurons, their partial transformation results in inappropriate subcellular localization of the Fz receptor, a likely cue for regulating ommatidial rotation. Secondly, reducing EGF signaling can specifically affect ommatidial rotation without showing transformation of the mystery cells or defects in polarity protein localization." @default.
• W2087658519 created "2016-06-24" @default.
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• W2087658519 date "2003-08-01" @default.
• W2087658519 modified "2023-09-27" @default.
• W2087658519 title "EGF Signaling and Ommatidial Rotation in the Drosophila Eye" @default.
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• W2087658519 doi "https://doi.org/10.1016/s0960-9822(03)00545-1" @default.
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