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- W2087662016 abstract "Studies on a variety of vertebrate and invertebrate nervous systems point to the existence of specific chemical cues for both growth cone guidance and target recognition. Open questions, however, include how many recognition labels and how specific is their expression? Here we review our recent studies on insect embryos aimed at trying to answer these questions, focusing in particular on the specificity of two identified growth cones (aCC and pCC) in the CNS of the grasshopper and Drosophila embryos. Ablation experiments demonstrate the selective affinities of the aCC and pCC growth cones for particular axonal surfaces; in some cases such ablations result in temporal and spatial transplants which further demonstrate this exquisite specificity. Our results suggest the differential expression of many different surface recognition molecules in the developing CNS (labelled pathways hypothesis), a notion reminiscent of Sperry's chemoaffinity hypothesis. The SOX2 monoclonal antibody reveals an antigen in the Drosophila embryo that correlates with this model: SOX2 is expressed by the aCC and the small subset of neurons whose axons fasciculate with it." @default.
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- W2087662016 date "1985-01-01" @default.
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- W2087662016 title "Neuronal specificity and growth cone guidance in grasshopper and Drosophila embryos" @default.
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- W2087662016 doi "https://doi.org/10.1016/0166-2236(85)90099-2" @default.
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