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• W2087662612 endingPage "S35" @default.
• W2087662612 startingPage "S23" @default.
• W2087662612 abstract "The discovery of the JAK2V617F mutation followed by the discovery of other genetic abnormalities allowed important progress in the understanding of the pathogenesis and management of myeloproliferative neoplasms (MPN)s. Classical Breakpoint cluster region-Abelson (BCR-ABL)-negative neoplasms include 3 main disorders: essential thrombocythemia (ET), polycythemia vera (PV), and primary myelofibrosis (PMF). Genomic studies have shown that these disorders are more heterogeneous than previously thought with 3 main entities corresponding to different gene mutations: the JAK2 disorder, essentially due to JAK2V617F mutation, which includes nearly all PVs and a majority of ETs and PMFs with a continuum between these diseases and the myeloproliferative leukemia (MPL) and calreticulin (CALR) disorders, which include a fraction of ET and PMF. All of these mutations lead to a JAK2 constitutive activation. Murine models either with JAK2V617F or MPLW515L, but also with JAK2 or MPL germ line mutations found in hereditary thrombocytosis, have demonstrated that they are drivers of myeloproliferation. However, the myeloproliferative driver mutation is still unknown in approximately 15% of ET and PMF, but appears to also target the JAK/Signal Transducer and Activator of Transcription (STAT) pathway. However, other mutations in genes involved in epigenetics or splicing also can be present and can predate or follow mutations in signaling. They are involved either in clonal dominance or in phenotypic changes, more particularly in PMF. They can be associated with leukemic progression and might have an important prognostic value such as additional sex comb-like 1 mutations. Despite this heterogeneity, it is tempting to target JAK2 and its signaling for therapy. However in PMF, Adenosine Tri-Phosphate (ATP)-competitive JAK2 inhibitors have shown their interest, but also their important limitations. Thus, other approaches are required, which are discussed in this review." @default.
• W2087662612 created "2016-06-24" @default.
• W2087662612 creator A5000559973 @default.
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• W2087662612 creator A5055524428 @default.
• W2087662612 creator A5061651965 @default.
• W2087662612 creator A5074874467 @default.
• W2087662612 date "2014-09-01" @default.
• W2087662612 modified "2023-10-07" @default.
• W2087662612 title "Myeloproliferative Neoplasms: JAK2 Signaling Pathway as a Central Target for Therapy" @default.
• W2087662612 cites W1570611984 @default.
• W2087662612 cites W1662539477 @default.
• W2087662612 cites W1963736125 @default.
• W2087662612 cites W1971183910 @default.
• W2087662612 cites W1973987664 @default.
• W2087662612 cites W1977164130 @default.
• W2087662612 cites W1977590248 @default.
• W2087662612 cites W1978228555 @default.
• W2087662612 cites W1978972655 @default.
• W2087662612 cites W1980568348 @default.
• W2087662612 cites W1981888767 @default.
• W2087662612 cites W1983412285 @default.
• W2087662612 cites W1984567268 @default.
• W2087662612 cites W1985809519 @default.
• W2087662612 cites W1987470267 @default.
• W2087662612 cites W1989336431 @default.
• W2087662612 cites W1990011854 @default.
• W2087662612 cites W1991885817 @default.
• W2087662612 cites W1992034794 @default.
• W2087662612 cites W1992320498 @default.
• W2087662612 cites W1992604276 @default.
• W2087662612 cites W1993934088 @default.
• W2087662612 cites W1994467709 @default.
• W2087662612 cites W1995370367 @default.
• W2087662612 cites W1995653573 @default.
• W2087662612 cites W1998367819 @default.
• W2087662612 cites W2001006614 @default.
• W2087662612 cites W2001546169 @default.
• W2087662612 cites W2003535009 @default.
• W2087662612 cites W2008429932 @default.
• W2087662612 cites W2009278301 @default.
• W2087662612 cites W2009621679 @default.
• W2087662612 cites W2011059916 @default.
• W2087662612 cites W2011466925 @default.
• W2087662612 cites W2012828222 @default.
• W2087662612 cites W2013425721 @default.
• W2087662612 cites W2013726626 @default.
• W2087662612 cites W2015113479 @default.
• W2087662612 cites W2015408128 @default.
• W2087662612 cites W2023278718 @default.
• W2087662612 cites W2025124131 @default.
• W2087662612 cites W2025391163 @default.
• W2087662612 cites W2026588020 @default.
• W2087662612 cites W2027201363 @default.
• W2087662612 cites W2028078153 @default.
• W2087662612 cites W2028334384 @default.
• W2087662612 cites W2031212958 @default.
• W2087662612 cites W2033745205 @default.
• W2087662612 cites W2034029229 @default.
• W2087662612 cites W2038195476 @default.
• W2087662612 cites W2041191257 @default.
• W2087662612 cites W2041532598 @default.
• W2087662612 cites W2046567666 @default.
• W2087662612 cites W2046982014 @default.
• W2087662612 cites W2049145190 @default.
• W2087662612 cites W2051577500 @default.
• W2087662612 cites W2052451894 @default.
• W2087662612 cites W2054200299 @default.
• W2087662612 cites W2055096888 @default.
• W2087662612 cites W2056777053 @default.
• W2087662612 cites W2057360098 @default.
• W2087662612 cites W2058251910 @default.
• W2087662612 cites W2059045913 @default.
• W2087662612 cites W2064453268 @default.
• W2087662612 cites W2067978068 @default.
• W2087662612 cites W2070658555 @default.
• W2087662612 cites W2071990094 @default.
• W2087662612 cites W2073726802 @default.
• W2087662612 cites W2073889874 @default.
• W2087662612 cites W2075075980 @default.
• W2087662612 cites W2078743099 @default.
• W2087662612 cites W2078972833 @default.
• W2087662612 cites W2079985837 @default.
• W2087662612 cites W2080316252 @default.
• W2087662612 cites W2081473305 @default.
• W2087662612 cites W2084831908 @default.
• W2087662612 cites W2084897544 @default.
• W2087662612 cites W2085404468 @default.
• W2087662612 cites W2088045605 @default.
• W2087662612 cites W2090885521 @default.
• W2087662612 cites W2093216476 @default.
• W2087662612 cites W2094200744 @default.
• W2087662612 cites W2094456737 @default.
• W2087662612 cites W2097743943 @default.
• W2087662612 cites W2097922857 @default.
• W2087662612 cites W2099264304 @default.
• W2087662612 cites W2107367045 @default.
• W2087662612 cites W2107715878 @default.

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