FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2087664062> ?p ?o ?g. }

• W2087664062 endingPage "576" @default.
• W2087664062 startingPage "569" @default.
• W2087664062 abstract "In postmenopausal women, an association between reduced bone mineral density (BMD) and increased number of circulating osteoprogenitor cells (COPs) has been found. Although an increased thyroid function is associated with BMD, thyroid hormones stimulate osteoblast function in vitro. We investigated whether thyroid hormones within the reference range were correlated with the number of COPs and stimulate mineralization in vitro. The number of COPs, defined as CD34+/alkaline phosphatase (AP)+ or CD34+/osteocalcin (OCN)+ cells, was quantified by fluorescence-activated cell sorting (FACS) analysis in 150 euthyroid postmenopausal women. Participants underwent measurement of serum free thyroxine (FT4), thyroid-stimulating hormone levels, and femur BMD. CD34+ cells were isolated from healthy volunteers irrespective of AP or OCN expression, and the effect of triiodothyronine (0.5-10 pmol/L)) on their ability to form mineralized nodules in vitro was studied. The number of COPs was highest among women with high-normal FT4 levels (>1.09 ng/dL). The FT4 levels were correlated positively with circulating log-CD34+/AP+ (r = 0.32, P < .001) and log-CD34/OCN+ cells (r = 0.36, P < .001) and inversely with total femur BMD (r = −0.17, P = .036) but not with femoral neck BMD. In a multivariate analysis, the FT4 levels were positively correlated with the number of COPs, independent of age and BMD. The ability of CD34+ cells to form mineralized nodules increased after exposure from low up to high-normal triiodothyronine concentrations (P for trend = .003). Among euthyroid postmenopausal women, high-normal FT4 levels are correlated with an increased number of circulating immature osteoprogenitor cells and a very mild BMD reduction. Exposure of CD34+ cells to physiological triiodothyronine concentrations stimulates mineralization in vitro." @default.
• W2087664062 created "2016-06-24" @default.
• W2087664062 creator A5001000458 @default.
• W2087664062 creator A5009957095 @default.
• W2087664062 creator A5016352385 @default.
• W2087664062 creator A5036965552 @default.
• W2087664062 creator A5052191319 @default.
• W2087664062 creator A5056699188 @default.
• W2087664062 creator A5076542346 @default.
• W2087664062 date "2012-04-01" @default.
• W2087664062 modified "2023-10-18" @default.
• W2087664062 title "Association between thyroid hormone levels, the number of circulating osteoprogenitor cells, and bone mineral density in euthyroid postmenopausal women" @default.
• W2087664062 cites W1965180760 @default.
• W2087664062 cites W1992075067 @default.
• W2087664062 cites W1992239128 @default.
• W2087664062 cites W1993564514 @default.
• W2087664062 cites W2000779652 @default.
• W2087664062 cites W2001347353 @default.
• W2087664062 cites W2004269531 @default.
• W2087664062 cites W2005378018 @default.
• W2087664062 cites W2009443264 @default.
• W2087664062 cites W2022475095 @default.
• W2087664062 cites W2025097655 @default.
• W2087664062 cites W2026851714 @default.
• W2087664062 cites W2034467401 @default.
• W2087664062 cites W2043774208 @default.
• W2087664062 cites W2052673490 @default.
• W2087664062 cites W2064635099 @default.
• W2087664062 cites W2065196538 @default.
• W2087664062 cites W2075408155 @default.
• W2087664062 cites W2076924317 @default.
• W2087664062 cites W2080802204 @default.
• W2087664062 cites W2093677271 @default.
• W2087664062 cites W2099677070 @default.
• W2087664062 cites W2109481093 @default.
• W2087664062 cites W2111206608 @default.
• W2087664062 cites W2117509950 @default.
• W2087664062 cites W2132962816 @default.
• W2087664062 cites W2135227451 @default.
• W2087664062 cites W2150756587 @default.
• W2087664062 cites W2164604567 @default.
• W2087664062 cites W4253262038 @default.
• W2087664062 doi "https://doi.org/10.1016/j.metabol.2011.09.006" @default.
• W2087664062 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22075271" @default.
• W2087664062 hasPublicationYear "2012" @default.
• W2087664062 type Work @default.
• W2087664062 sameAs 2087664062 @default.
• W2087664062 citedByCount "6" @default.
• W2087664062 countsByYear W20876640622012 @default.
• W2087664062 countsByYear W20876640622013 @default.
• W2087664062 countsByYear W20876640622019 @default.
• W2087664062 countsByYear W20876640622020 @default.
• W2087664062 countsByYear W20876640622021 @default.
• W2087664062 crossrefType "journal-article" @default.
• W2087664062 hasAuthorship W2087664062A5001000458 @default.
• W2087664062 hasAuthorship W2087664062A5009957095 @default.
• W2087664062 hasAuthorship W2087664062A5016352385 @default.
• W2087664062 hasAuthorship W2087664062A5036965552 @default.
• W2087664062 hasAuthorship W2087664062A5052191319 @default.
• W2087664062 hasAuthorship W2087664062A5056699188 @default.
• W2087664062 hasAuthorship W2087664062A5076542346 @default.
• W2087664062 hasConcept C10205521 @default.
• W2087664062 hasConcept C126322002 @default.
• W2087664062 hasConcept C131075544 @default.
• W2087664062 hasConcept C134018914 @default.
• W2087664062 hasConcept C160160445 @default.
• W2087664062 hasConcept C181199279 @default.
• W2087664062 hasConcept C185592680 @default.
• W2087664062 hasConcept C2776541429 @default.
• W2087664062 hasConcept C2776886416 @default.
• W2087664062 hasConcept C2777195454 @default.
• W2087664062 hasConcept C28328180 @default.
• W2087664062 hasConcept C2993291352 @default.
• W2087664062 hasConcept C526584372 @default.
• W2087664062 hasConcept C54355233 @default.
• W2087664062 hasConcept C55493867 @default.
• W2087664062 hasConcept C71315377 @default.
• W2087664062 hasConcept C71924100 @default.
• W2087664062 hasConcept C86803240 @default.
• W2087664062 hasConceptScore W2087664062C10205521 @default.
• W2087664062 hasConceptScore W2087664062C126322002 @default.
• W2087664062 hasConceptScore W2087664062C131075544 @default.
• W2087664062 hasConceptScore W2087664062C134018914 @default.
• W2087664062 hasConceptScore W2087664062C160160445 @default.
• W2087664062 hasConceptScore W2087664062C181199279 @default.
• W2087664062 hasConceptScore W2087664062C185592680 @default.
• W2087664062 hasConceptScore W2087664062C2776541429 @default.
• W2087664062 hasConceptScore W2087664062C2776886416 @default.
• W2087664062 hasConceptScore W2087664062C2777195454 @default.
• W2087664062 hasConceptScore W2087664062C28328180 @default.
• W2087664062 hasConceptScore W2087664062C2993291352 @default.
• W2087664062 hasConceptScore W2087664062C526584372 @default.
• W2087664062 hasConceptScore W2087664062C54355233 @default.
• W2087664062 hasConceptScore W2087664062C55493867 @default.
• W2087664062 hasConceptScore W2087664062C71315377 @default.
• W2087664062 hasConceptScore W2087664062C71924100 @default.
• W2087664062 hasConceptScore W2087664062C86803240 @default.
• W2087664062 hasFunder F4320322672 @default.

• next