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• W2087664980 abstract "A structure–activity relationship study to elucidate the structural basis for hedgehog (Hh) signaling inhibition by vitamin D3 (VD3) was performed. Functional and non-functional regions of VD3 and VD2 were obtained through straightforward synthetic means and their biological activity was determined in a variety of cell-based assays. Several of these compounds inhibited Hh signaling at levels comparable to the parent VD3 with no effects on canonical vitamin D signaling. Most notably, compounds 5 and 9, demonstrated potent inhibition of the Hh pathway, exhibited no binding affinity for the vitamin D receptor (VDR), and did not activate VDR in cell culture. In addition, several compounds exhibited anti-proliferative activity against two human cancer cell lines through a mechanism distinct from the Hh or VDR pathways, suggesting a new cellular mechanism of action for this class of compounds." @default.
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• W2087664980 date "2012-07-01" @default.
• W2087664980 modified "2023-09-24" @default.
• W2087664980 title "Probing the structural requirements for vitamin D3 inhibition of the hedgehog signaling pathway" @default.
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• W2087664980 doi "https://doi.org/10.1016/j.bmcl.2012.05.037" @default.
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