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• W2087666519 endingPage "12526" @default.
• W2087666519 startingPage "12526" @default.
• W2087666519 abstract "Cell death has been extensively evaluated for decades and it is well recognized that pharmacological interventions directed to inhibit cell death can prevent significant cell loss and can thus improve an organ's physiological function. For long, only apoptosis was considered as a sole form of programmed cell death. Recently necroptosis, a RIP1/RIP3-dependent programmed cell death, has been identified as an apoptotic backup cell death mechanism with necrotic morphology. The evidences of necroptosis and protective effects achieved by blocking necroptosis have been extensively reported in recent past. However, only a few studies reported the evidence of necroptosis and protective effects achieved by inhibiting necroptosis in liver related disease conditions. Although the number of necroptosis initiators is increasing; however, interestingly, it is still unclear that what actually triggers necroptosis in different liver diseases or if there is always a different necroptosis initiator in each specific disease condition followed by specific downstream signaling molecules. Understanding the precise mechanism of necroptosis as well as counteracting other cell death pathways in liver diseases could provide a useful insight towards achieving extensive therapeutic significance. By targeting necroptosis and/or other parallel death pathways, a significant cell loss and thus a decrement in an organ's physiological function can be prevented." @default.
• W2087666519 created "2016-06-24" @default.
• W2087666519 creator A5041127618 @default.
• W2087666519 creator A5073967981 @default.
• W2087666519 date "2014-01-01" @default.
• W2087666519 modified "2023-09-24" @default.
• W2087666519 title "Necroptosis: An emerging type of cell death in liver diseases" @default.
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• W2087666519 doi "https://doi.org/10.3748/wjg.v20.i35.12526" @default.
• W2087666519 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4168087" @default.
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• W2087666519 hasPublicationYear "2014" @default.
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