Matches in SemOpenAlex for { <https://semopenalex.org/work/W2087669027> ?p ?o ?g. }
- W2087669027 endingPage "47" @default.
- W2087669027 startingPage "38" @default.
- W2087669027 abstract "In rats, partial injury to a peripheral nerve often leads to sympathetically maintained pain (SMP). In humans, this condition is especially apparent in the elderly. Nerve injury also causes perivascular sympathetic axons to sprout into the dorsal root ganglion (DRG), forming a possible anatomical substrate for SMP. Here, we describe the effects of chronic sciatic nerve constriction injury (CCI) in young (3 months) and old (16 months) rats on neuropathic pain behavior and on sympathetic sprouting in DRG. Behavioral tests assessed changes in thermal allodynia and hyperalgesia and in mechanical allodynia. We found that 1) sympathetic innervation of the DRG increased naturally with age, forming pericellular baskets mainly around large DRG neurons, and that sympathetic fibers were often associated with myelinated sensory axons; 2) sympathetic fiber density following CCI was also greater in old than in young rats; and 3) in old rats, thermal allodynia was less pronounced than in young rats, whereas thermal hyperalgesia and mechanical allodynia were more pronounced. These results highlight the possibility that sympathetic sprouting in the DRG is responsible for the sympathetic generation or maintenance of pain, especially in the elderly." @default.
- W2087669027 created "2016-06-24" @default.
- W2087669027 creator A5012764803 @default.
- W2087669027 creator A5033993630 @default.
- W2087669027 date "1998-04-27" @default.
- W2087669027 modified "2023-09-24" @default.
- W2087669027 title "Normal and injury-induced sympathetic innervation of rat dorsal root ganglia increases with age" @default.
- W2087669027 cites W1672091529 @default.
- W2087669027 cites W1756898524 @default.
- W2087669027 cites W1921979143 @default.
- W2087669027 cites W1965765982 @default.
- W2087669027 cites W1965866432 @default.
- W2087669027 cites W1968725631 @default.
- W2087669027 cites W1969981702 @default.
- W2087669027 cites W1970491289 @default.
- W2087669027 cites W1971936787 @default.
- W2087669027 cites W1977051447 @default.
- W2087669027 cites W1982541800 @default.
- W2087669027 cites W1983028276 @default.
- W2087669027 cites W1985005927 @default.
- W2087669027 cites W1985620158 @default.
- W2087669027 cites W1986585534 @default.
- W2087669027 cites W1986662264 @default.
- W2087669027 cites W1989867245 @default.
- W2087669027 cites W1991550485 @default.
- W2087669027 cites W1995398247 @default.
- W2087669027 cites W1996961163 @default.
- W2087669027 cites W1997453270 @default.
- W2087669027 cites W2003481642 @default.
- W2087669027 cites W2005135333 @default.
- W2087669027 cites W2006279071 @default.
- W2087669027 cites W2007974062 @default.
- W2087669027 cites W2009374031 @default.
- W2087669027 cites W2009634943 @default.
- W2087669027 cites W2010333149 @default.
- W2087669027 cites W2010748414 @default.
- W2087669027 cites W2014007136 @default.
- W2087669027 cites W2017872209 @default.
- W2087669027 cites W2023771303 @default.
- W2087669027 cites W2025794199 @default.
- W2087669027 cites W2025975103 @default.
- W2087669027 cites W2029076925 @default.
- W2087669027 cites W2034090310 @default.
- W2087669027 cites W2036290497 @default.
- W2087669027 cites W2037490409 @default.
- W2087669027 cites W2048981848 @default.
- W2087669027 cites W2050646098 @default.
- W2087669027 cites W2055383790 @default.
- W2087669027 cites W2057249572 @default.
- W2087669027 cites W2058020736 @default.
- W2087669027 cites W2067748675 @default.
- W2087669027 cites W2067924690 @default.
- W2087669027 cites W2069351628 @default.
- W2087669027 cites W2070527334 @default.
- W2087669027 cites W2072167920 @default.
- W2087669027 cites W2082805021 @default.
- W2087669027 cites W2095051237 @default.
- W2087669027 cites W2107942582 @default.
- W2087669027 cites W2110795584 @default.
- W2087669027 cites W2140223874 @default.
- W2087669027 cites W2164934154 @default.
- W2087669027 cites W2321165254 @default.
- W2087669027 cites W2334319689 @default.
- W2087669027 cites W2398300002 @default.
- W2087669027 doi "https://doi.org/10.1002/(sici)1096-9861(19980427)394:1<38::aid-cne4>3.0.co;2-i" @default.
- W2087669027 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9550141" @default.
- W2087669027 hasPublicationYear "1998" @default.
- W2087669027 type Work @default.
- W2087669027 sameAs 2087669027 @default.
- W2087669027 citedByCount "39" @default.
- W2087669027 countsByYear W20876690272013 @default.
- W2087669027 countsByYear W20876690272014 @default.
- W2087669027 countsByYear W20876690272015 @default.
- W2087669027 countsByYear W20876690272016 @default.
- W2087669027 countsByYear W20876690272018 @default.
- W2087669027 countsByYear W20876690272022 @default.
- W2087669027 countsByYear W20876690272023 @default.
- W2087669027 crossrefType "journal-article" @default.
- W2087669027 hasAuthorship W2087669027A5012764803 @default.
- W2087669027 hasAuthorship W2087669027A5033993630 @default.
- W2087669027 hasConcept C105702510 @default.
- W2087669027 hasConcept C126322002 @default.
- W2087669027 hasConcept C140530291 @default.
- W2087669027 hasConcept C15490471 @default.
- W2087669027 hasConcept C169760540 @default.
- W2087669027 hasConcept C170493617 @default.
- W2087669027 hasConcept C2775991916 @default.
- W2087669027 hasConcept C2776281502 @default.
- W2087669027 hasConcept C2776533406 @default.
- W2087669027 hasConcept C2776880756 @default.
- W2087669027 hasConcept C2777107010 @default.
- W2087669027 hasConcept C2777883359 @default.
- W2087669027 hasConcept C2778241760 @default.
- W2087669027 hasConcept C2779245659 @default.
- W2087669027 hasConcept C2781149210 @default.
- W2087669027 hasConcept C42219234 @default.
- W2087669027 hasConcept C59822182 @default.
- W2087669027 hasConcept C71924100 @default.