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• W2087680341 abstract "El fallo agudo del injerto (FAI) se define como un fracaso significativo en la función miocárdica del corazón recién implantado. El objetivo de este trabajo fue estudiar una serie de factores relacionados con el trasplante cardíaco (TC) y analizar su relación con el FAI. Se han incluido 287 TC consecutivos realizados en un período de 14 años. Se consideró FAI cuando: a) el cirujano observó disfunción ventricular antes del cierre esternal; b) existió la necesidad de utilizar varios fármacos inotropos a altas dosis, o c) se produjo disfunción ventricular en las ecocardiografías durante el postoperatorio inmediato. Las variables se analizaron desde un punto de vista descriptivo, univariante y multivariante (modelo de regresión logística). La incidencia del FAI fue del 22%. Las variables predictoras de fallo agudo del injerto fueron: donante de sexo femenino (OR = 2,2; IC del 95%, 1,2–4,4; p = 0,02), discordancia mayor del 20% entre el peso del receptor y el del donante (OR = 2,2; IC del 95%, 1,1–4,3; p = 0,02) y cardiopatía de base isquémica (OR = 2,5; IC del 95%, 5,7–1,1; p = 0,03) o valvular (OR = 5,0; IC del 95%, 7,0–1,5; p = 0,01). El FAI es una afección bastante frecuente que se presenta, al margen de su gravedad, hasta en el 22% de los trasplantados cardíacos. Entre los factores modificables asociados a su presentación podemos encontrar la desproporción de pesos y el sexo femenino del donante. Los factores no modificables serían la cardiopatía isquémica y las valvulopatías como causa del trasplante. Acute graft failure (AGF) is defined as significant failure of myocardial function in a newly implanted heart. The aim of the present study was to investigate a series of factors related to heart transplantation (HT) in relation to AGF. In a study of 287 consecutive HTs performed over a 14-year period, AGF was defined when: a) the surgeon observed ventricular dysfunction before closing the sternotomy; b) various inotropic drugs were required at high doses in the first days after surgery, or c) ventricular dysfunction was identified by routine echocardiography in the immediate postoperative period. Statistical analysis comprised a descriptive and univariate comparative study, followed by multivariate analysis based on application of a logistical regression model. The incidence of AGF was 22%. Predictors of AGF were female donor status (OR = 2.2; 95% CI, 1.2–4.4; p = 0.02), a disproportion of more than 20% in donor-recipient body weight (OR = 2.2; 95% CI, 1.1–4.3; p = 0.02), and background ischemic heart disease (OR = 2.5; 95% CI, 5.5–1.1; p = 0.03) or valve pathology (OR = 5.0; 95% CI, 7.0–1.5; p = 0.01). AGF is a frequent pathology, which was present in 22% of our heart transplantation patients. Among the modifiable factors related to AGF was a clear disproportion in body weight and the size of grafts from female donors. Unmodifiable factors related to AGF were ischemic heart disease and valvular heart disease as a cause of heart transplantation." @default.
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• W2087680341 date "2003-01-01" @default.
• W2087680341 modified "2023-10-18" @default.
• W2087680341 title "Análisis de los factores que pueden influir en la aparición del fallo agudo del corazón trasplantado" @default.
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• W2087680341 doi "https://doi.org/10.1016/s0300-8932(03)76841-9" @default.
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