FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2087680614> ?p ?o ?g. }

• W2087680614 endingPage "1149" @default.
• W2087680614 startingPage "1143" @default.
• W2087680614 abstract "Currently, chemoradiation treatment strategies in locally advanced NSCLC are essentially the same irrespective of tumor histology or patient age. The purpose of this study is to analyze the impact of age, histology, Karnofsky performance status (KPS), and specific toxicities on the median survival time (MST) and quality-adjusted survival (QTime) for each treatment strategy.Nine hundred seventy-nine patients with Stage II-IIIB inoperable NSCLC were enrolled on 6 prospective Phase II and III studies from 1983 to 1995. Treatment regimens ranged from standard RT (SRT) to 60 Gy, hyperfractionated RT (HRT) to 69.6 Gy, induction chemotherapy (ICT) of cisplatin (CIS) and vinblastine (VBL) followed by SRT, ICT + concurrent CT (CCT) + SRT, and CCT + HRT; CCT consisted of etoposide or VBL + CIS. Toxicities assessed were skin, mucous membrane, lung, esophagus, neurologic, hematologic, and upper GI. QTime was calculated by weighting the time spent with a specific toxicity, as well as local or distant tumor progression. Each toxicity was weighted with increasing severity as the toxicity increased in grade.As expected, patients with the worst KPS (50-70) had the lowest MST (7.8 months) and QTime (6.7 months). Patients <70 years had improved survival with more aggressive therapy (i.e., ICT + SRT or CCT + HRT), while patients > 70 years achieved the best QTime with standard RT (SRT) alone. In patients with squamous cell carcinoma, those treated with ICT + CCT + SRT had dramatically improved MST (25.7 months) and QTime (21.8 months) compared to the other treatment regimens (11.7-12.8 and 10.7-12 months, respectively). Patients with adenocarcinoma, however, generally manifested incrementally better MST and QTime as the therapies intensified. Within the concurrent chemoradiation arms, the upper GI and lung toxicities had the greatest impact on QTime.This quality-adjusted survival analysis suggests that there is a critical relationship between the type of histology and its optimal treatment, age and the ability to tolerate intensive therapy, and the need to reduce lung and upper GI toxicities." @default.
• W2087680614 created "2016-06-24" @default.
• W2087680614 creator A5004625690 @default.
• W2087680614 creator A5006430883 @default.
• W2087680614 creator A5011307937 @default.
• W2087680614 creator A5014161715 @default.
• W2087680614 creator A5030653008 @default.
• W2087680614 creator A5031587883 @default.
• W2087680614 creator A5034765756 @default.
• W2087680614 creator A5057333651 @default.
• W2087680614 creator A5067077795 @default.
• W2087680614 creator A5074206651 @default.
• W2087680614 creator A5075104864 @default.
• W2087680614 creator A5085643126 @default.
• W2087680614 creator A5089472018 @default.
• W2087680614 date "1999-12-01" @default.
• W2087680614 modified "2023-10-18" @default.
• W2087680614 title "The benefit of treatment intensification is age and histology-dependent in patients with locally advanced non-small cell lung cancer (NSCLC): a quality-adjusted survival analysis of radiation therapy oncology group (RTOG) chemoradiation studies" @default.
• W2087680614 cites W1814695252 @default.
• W2087680614 cites W1831241863 @default.
• W2087680614 cites W1966475493 @default.
• W2087680614 cites W1967464736 @default.
• W2087680614 cites W1974517449 @default.
• W2087680614 cites W2014145691 @default.
• W2087680614 cites W2017967967 @default.
• W2087680614 cites W2019926572 @default.
• W2087680614 cites W2021775131 @default.
• W2087680614 cites W2043945205 @default.
• W2087680614 cites W2050226406 @default.
• W2087680614 cites W2062248834 @default.
• W2087680614 cites W2067096286 @default.
• W2087680614 cites W2078752897 @default.
• W2087680614 cites W2164559143 @default.
• W2087680614 cites W2226077283 @default.
• W2087680614 cites W2272066842 @default.
• W2087680614 cites W2334360477 @default.
• W2087680614 cites W2341745217 @default.
• W2087680614 cites W4293241248 @default.
• W2087680614 doi "https://doi.org/10.1016/s0360-3016(99)00325-9" @default.
• W2087680614 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10613306" @default.
• W2087680614 hasPublicationYear "1999" @default.
• W2087680614 type Work @default.
• W2087680614 sameAs 2087680614 @default.
• W2087680614 citedByCount "112" @default.
• W2087680614 countsByYear W20876806142012 @default.
• W2087680614 countsByYear W20876806142013 @default.
• W2087680614 countsByYear W20876806142014 @default.
• W2087680614 countsByYear W20876806142015 @default.
• W2087680614 countsByYear W20876806142016 @default.
• W2087680614 countsByYear W20876806142017 @default.
• W2087680614 countsByYear W20876806142019 @default.
• W2087680614 countsByYear W20876806142020 @default.
• W2087680614 countsByYear W20876806142021 @default.
• W2087680614 countsByYear W20876806142022 @default.
• W2087680614 countsByYear W20876806142023 @default.
• W2087680614 crossrefType "journal-article" @default.
• W2087680614 hasAuthorship W2087680614A5004625690 @default.
• W2087680614 hasAuthorship W2087680614A5006430883 @default.
• W2087680614 hasAuthorship W2087680614A5011307937 @default.
• W2087680614 hasAuthorship W2087680614A5014161715 @default.
• W2087680614 hasAuthorship W2087680614A5030653008 @default.
• W2087680614 hasAuthorship W2087680614A5031587883 @default.
• W2087680614 hasAuthorship W2087680614A5034765756 @default.
• W2087680614 hasAuthorship W2087680614A5057333651 @default.
• W2087680614 hasAuthorship W2087680614A5067077795 @default.
• W2087680614 hasAuthorship W2087680614A5074206651 @default.
• W2087680614 hasAuthorship W2087680614A5075104864 @default.
• W2087680614 hasAuthorship W2087680614A5085643126 @default.
• W2087680614 hasAuthorship W2087680614A5089472018 @default.
• W2087680614 hasConcept C126322002 @default.
• W2087680614 hasConcept C141071460 @default.
• W2087680614 hasConcept C143998085 @default.
• W2087680614 hasConcept C2776256026 @default.
• W2087680614 hasConcept C2776694085 @default.
• W2087680614 hasConcept C2776907518 @default.
• W2087680614 hasConcept C2778119113 @default.
• W2087680614 hasConcept C29730261 @default.
• W2087680614 hasConcept C509974204 @default.
• W2087680614 hasConcept C57742111 @default.
• W2087680614 hasConcept C71924100 @default.
• W2087680614 hasConcept C90924648 @default.
• W2087680614 hasConceptScore W2087680614C126322002 @default.
• W2087680614 hasConceptScore W2087680614C141071460 @default.
• W2087680614 hasConceptScore W2087680614C143998085 @default.
• W2087680614 hasConceptScore W2087680614C2776256026 @default.
• W2087680614 hasConceptScore W2087680614C2776694085 @default.
• W2087680614 hasConceptScore W2087680614C2776907518 @default.
• W2087680614 hasConceptScore W2087680614C2778119113 @default.
• W2087680614 hasConceptScore W2087680614C29730261 @default.
• W2087680614 hasConceptScore W2087680614C509974204 @default.
• W2087680614 hasConceptScore W2087680614C57742111 @default.
• W2087680614 hasConceptScore W2087680614C71924100 @default.
• W2087680614 hasConceptScore W2087680614C90924648 @default.
• W2087680614 hasIssue "5" @default.
• W2087680614 hasLocation W20876806141 @default.
• W2087680614 hasLocation W20876806142 @default.
• W2087680614 hasOpenAccess W2087680614 @default.
• W2087680614 hasPrimaryLocation W20876806141 @default.

• next